Name | Number of supported studies | Average coverage | |
|---|---|---|---|
| macrophage | 32 studies | 30% ± 12% | |
| B cell | 21 studies | 24% ± 7% | |
| classical monocyte | 18 studies | 32% ± 15% | |
| memory B cell | 15 studies | 27% ± 6% | |
| monocyte | 13 studies | 27% ± 13% | |
| regulatory T cell | 13 studies | 23% ± 4% | |
| naive B cell | 11 studies | 20% ± 6% | |
| mast cell | 10 studies | 22% ± 8% | |
| myeloid cell | 9 studies | 32% ± 9% | |
| conventional dendritic cell | 8 studies | 29% ± 10% | |
| plasmacytoid dendritic cell | 8 studies | 24% ± 4% | |
| non-classical monocyte | 7 studies | 29% ± 9% | |
| plasma cell | 6 studies | 27% ± 8% | |
| neutrophil | 6 studies | 34% ± 11% | |
| hematopoietic precursor cell | 5 studies | 28% ± 6% | |
| mononuclear phagocyte | 5 studies | 31% ± 18% | |
| hematopoietic stem cell | 4 studies | 19% ± 0% | |
| dendritic cell | 4 studies | 33% ± 10% | |
| alveolar macrophage | 4 studies | 21% ± 4% | |
| plasmablast | 3 studies | 39% ± 13% | |
| leukocyte | 3 studies | 27% ± 6% | |
| precursor B cell | 3 studies | 25% ± 6% | |
| immature B cell | 3 studies | 30% ± 9% | |
| tissue-resident macrophage | 3 studies | 29% ± 8% | |
| germinal center B cell | 3 studies | 25% ± 7% | |
| effector CD4-positive, alpha-beta T cell | 3 studies | 24% ± 8% | |
| intermediate monocyte | 3 studies | 42% ± 13% | |
| megakaryocyte-erythroid progenitor cell | 3 studies | 45% ± 16% |
Name | Number of supported studies | Average coverage | |
|---|---|---|---|
| peripheral blood | 4 studies | 25% ± 10% |
Tissue | GTEx Coverage | GTEx Average TPM | GTEx Number of samples | TCGA Coverage | TCGA Average TPM | TCGA Number of samples |
|---|---|---|---|---|---|---|
| lung | 100% | 2999.83 | 578 / 578 | 97% | 19.85 | 1120 / 1155 |
| bladder | 100% | 893.00 | 21 / 21 | 93% | 18.89 | 468 / 504 |
| intestine | 96% | 1328.62 | 930 / 966 | 93% | 14.47 | 488 / 527 |
| breast | 92% | 809.87 | 421 / 459 | 96% | 12.16 | 1068 / 1118 |
| thymus | 79% | 533.32 | 518 / 653 | 85% | 12.25 | 515 / 605 |
| adrenal gland | 98% | 901.17 | 252 / 258 | 64% | 6.05 | 148 / 230 |
| stomach | 67% | 424.35 | 239 / 359 | 95% | 14.24 | 271 / 286 |
| kidney | 73% | 495.17 | 65 / 89 | 88% | 13.18 | 793 / 901 |
| esophagus | 80% | 497.76 | 1151 / 1445 | 80% | 6.44 | 146 / 183 |
| uterus | 52% | 257.58 | 89 / 170 | 92% | 14.08 | 423 / 459 |
| prostate | 77% | 475.04 | 189 / 245 | 66% | 4.20 | 332 / 502 |
| liver | 55% | 284.88 | 125 / 226 | 71% | 6.88 | 289 / 406 |
| skin | 35% | 156.44 | 629 / 1809 | 90% | 15.43 | 424 / 472 |
| brain | 19% | 94.67 | 510 / 2642 | 91% | 13.02 | 640 / 705 |
| pancreas | 16% | 70.60 | 51 / 328 | 94% | 18.04 | 167 / 178 |
| ovary | 24% | 117.76 | 43 / 180 | 78% | 6.55 | 336 / 430 |
| lymph node | 0% | 0 | 0 / 0 | 100% | 122.78 | 29 / 29 |
| peripheral blood | 100% | 29172.38 | 929 / 929 | 0% | 0 | 0 / 0 |
| spleen | 100% | 10414.86 | 241 / 241 | 0% | 0 | 0 / 0 |
| adipose | 99% | 1611.47 | 1195 / 1204 | 0% | 0 | 0 / 0 |
| tonsil | 0% | 0 | 0 / 0 | 93% | 20.73 | 42 / 45 |
| blood vessel | 69% | 614.63 | 916 / 1335 | 0% | 0 | 0 / 0 |
| eye | 0% | 0 | 0 / 0 | 59% | 5.35 | 47 / 80 |
| heart | 54% | 278.57 | 469 / 861 | 0% | 0 | 0 / 0 |
| muscle | 12% | 43.37 | 93 / 803 | 0% | 0 | 0 / 0 |
| abdomen | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| bone marrow | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| diaphragm | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| gingiva | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| nasal cavity | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| nasopharynx | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| nose | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| placenta | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| spinal column | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| ureter | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 1 |
| GO_0045730 | Biological process | respiratory burst |
| GO_0042554 | Biological process | superoxide anion generation |
| GO_0006909 | Biological process | phagocytosis |
| GO_0032010 | Cellular component | phagolysosome |
| GO_0010008 | Cellular component | endosome membrane |
| GO_0005829 | Cellular component | cytosol |
| GO_0043020 | Cellular component | NADPH oxidase complex |
| GO_0005886 | Cellular component | plasma membrane |
| GO_0016020 | Cellular component | membrane |
| GO_0005737 | Cellular component | cytoplasm |
| GO_0016176 | Molecular function | superoxide-generating NADPH oxidase activator activity |
| GO_0032266 | Molecular function | phosphatidylinositol-3-phosphate binding |
| GO_0005515 | Molecular function | protein binding |
| Gene name | NCF4 |
| Protein name | Neutrophil cytosol factor 4 (NCF-4) (Neutrophil NADPH oxidase factor 4) (SH3 and PX domain-containing protein 4) (p40-phox) (p40phox) Neutrophil cytosol factor 4 (Neutrophil cytosolic factor 4, 40kDa, isoform CRA_a) Neutrophil cytosol factor 4 (Neutrophil cytosolic factor 4) NCF4 protein Neutrophil cytosol factor 4 Neutrophil cytosolic factor 4 |
| Synonyms | SH3PXD4 hCG_40038 |
| Description | FUNCTION: Component of the NADPH-oxidase, a multicomponent enzyme system responsible for the oxidative burst in which electrons are transported from NADPH to molecular oxygen, generating reactive oxidant intermediates. It may be important for the assembly and/or activation of the NADPH-oxidase complex. . |
| Accessions | Q15080 A0A0G2JR51 ENST00000625504.2 B0QY04 ENST00000628938.2 ENST00000614157.1 ENST00000447071.5 ENST00000650827.1 Q6FGM9 A0A217FLJ2 ENST00000626011.2 A0A494BZS1 ENST00000650698.1 ENST00000397147.7 [Q15080-3] ENST00000248899.11 [Q15080-1] |