NAA50 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0071962Biological processmitotic sister chromatid cohesion, centromeric
GO_0034087Biological processestablishment of mitotic sister chromatid cohesion
GO_0006338Biological processchromatin remodeling
GO_0006474Biological processN-terminal protein amino acid acetylation
GO_0007064Biological processmitotic sister chromatid cohesion
GO_0005730Cellular componentnucleolus
GO_0031415Cellular componentNatA complex
GO_0070062Cellular componentextracellular exosome
GO_0005829Cellular componentcytosol
GO_0005737Cellular componentcytoplasm
GO_0005634Cellular componentnucleus
GO_0010485Molecular functionhistone H4 acetyltransferase activity
GO_0004596Molecular functionpeptide alpha-N-acetyltransferase activity
GO_0005515Molecular functionprotein binding
GO_0052858Molecular functionpeptidyl-lysine acetyltransferase activity

IV. Literature review

[source]
Gene nameNAA50
Protein nameN-alpha-acetyltransferase 50, NatE catalytic subunit
N-alpha-acetyltransferase 50 (EC 2.3.1.258) (N-epsilon-acetyltransferase 50) (NatE catalytic subunit)
N-alpha-acetyltransferase 50 (hNaa50p) (EC 2.3.1.258) (N-acetyltransferase 13) (N-acetyltransferase 5) (hNAT5) (N-acetyltransferase san homolog) (hSAN) (N-epsilon-acetyltransferase 50) (EC 2.3.1.-) (NatE catalytic subunit)
SynonymsMAK3
NAT13
NAT5
DescriptionFUNCTION: N-alpha-acetyltransferase that acetylates the N-terminus of proteins that retain their initiating methionine . Has a broad substrate specificity: able to acetylate the initiator methionine of most peptides, except for those with a proline in second position . Also displays N-epsilon-acetyltransferase activity by mediating acetylation of the side chain of specific lysines on proteins . Autoacetylates in vivo . The relevance of N-epsilon-acetyltransferase activity is however unclear: able to acetylate H4 in vitro, but this result has not been confirmed in vivo . Component of N-alpha-acetyltransferase complexes containing NAA10 and NAA15, which has N-alpha-acetyltransferase activity . Does not influence the acetyltransferase activity of NAA10 . However, it negatively regulates the N-alpha-acetyltransferase activity of the N-terminal acetyltransferase A complex (also called the NatA complex) . The multiprotein complexes probably constitute the major contributor for N-terminal acetylation at the ribosome exit tunnel, with NAA10 acetylating all amino termini that are devoid of methionine and NAA50 acetylating other peptides . Required for sister chromatid cohesion during mitosis by promoting binding of CDCA5/sororin to cohesin: may act by counteracting the function of NAA10 . .

AccessionsENST00000240922.8 [Q9GZZ1-1]
Q9GZZ1
ENST00000497525.5
E7EQ69
B0AZT5
ENST00000630058.1
C9J5D1
ENST00000477813.5
ENST00000493900.5
C9JZU6
ENST00000478020.1
F8WCK0
A0A0D9SF32
C9J5J3
ENST00000493454.5
ENST00000497255.1
ENST00000481432.5