MTLN | OmnibusX

I. Expression across cell types

Name	Number of supported studies	Average coverage
endothelial cell	13 studies	26% ± 10%	Explore
CD8-positive, alpha-beta T cell	10 studies	19% ± 3%	Explore
regulatory T cell	9 studies	19% ± 1%	Explore
basal cell	7 studies	28% ± 14%	Explore
ciliated cell	7 studies	32% ± 14%	Explore
macrophage	7 studies	24% ± 8%	Explore
endothelial cell of lymphatic vessel	7 studies	23% ± 7%	Explore
naive thymus-derived CD8-positive, alpha-beta T cell	6 studies	20% ± 3%	Explore
smooth muscle cell	6 studies	19% ± 3%	Explore
epithelial cell	6 studies	45% ± 14%	Explore
classical monocyte	5 studies	20% ± 4%	Explore
capillary endothelial cell	5 studies	17% ± 1%	Explore
enterocyte	5 studies	18% ± 1%	Explore
fibroblast	5 studies	30% ± 13%	Explore
CD4-positive, alpha-beta T cell	5 studies	20% ± 4%	Explore
naive thymus-derived CD4-positive, alpha-beta T cell	5 studies	19% ± 4%	Explore
conventional dendritic cell	4 studies	22% ± 8%	Explore
kidney loop of Henle epithelial cell	4 studies	21% ± 3%	Explore
epithelial cell of proximal tubule	4 studies	23% ± 3%	Explore
endothelial cell of artery	4 studies	18% ± 3%	Explore
type II pneumocyte	4 studies	28% ± 17%	Explore
effector CD8-positive, alpha-beta T cell	4 studies	19% ± 3%	Explore
endothelial cell of vascular tree	4 studies	20% ± 2%	Explore
pericyte	4 studies	21% ± 3%	Explore
gamma-delta T cell	4 studies	22% ± 7%	Explore
CD4-positive, alpha-beta memory T cell	3 studies	20% ± 2%	Explore
CD8-positive, alpha-beta memory T cell	3 studies	17% ± 1%	Explore
T cell	3 studies	17% ± 2%	Explore
club cell	3 studies	20% ± 6%	Explore
secretory cell	3 studies	28% ± 15%	Explore
non-classical monocyte	3 studies	21% ± 4%	Explore
retinal ganglion cell	3 studies	55% ± 24%	Explore
CD16-positive, CD56-dim natural killer cell, human	3 studies	17% ± 1%	Explore
natural killer cell	3 studies	18% ± 1%	Explore
exhausted T cell	3 studies	20% ± 1%	Explore
intermediate monocyte	3 studies	22% ± 5%	Explore
dendritic cell	3 studies	28% ± 7%	Explore
vein endothelial cell	3 studies	20% ± 2%	Explore
plasmacytoid dendritic cell	3 studies	19% ± 5%	Explore

II. Expression across tissues

Name	Number of supported studies	Average coverage
lung	7 studies	24% ± 11%	Explore
peripheral blood	6 studies	18% ± 2%	Explore
kidney	4 studies	19% ± 3%	Explore
brain	4 studies	20% ± 6%	Explore

Tissue	GTEx Coverage	GTEx Average TPM	GTEx Number of samples	TCGA Coverage	TCGA Average TPM	TCGA Number of samples
adrenal gland	100%	846.76	258 / 258	99%	31.94	227 / 230
thymus	100%	679.03	652 / 653	99%	28.00	598 / 605
intestine	100%	783.22	966 / 966	99%	27.97	520 / 527
brain	99%	725.01	2624 / 2642	99%	24.51	700 / 705
prostate	100%	666.43	244 / 245	98%	23.79	494 / 502
ovary	100%	422.38	180 / 180	98%	28.36	420 / 430
kidney	100%	820.89	89 / 89	97%	21.50	877 / 901
liver	100%	530.69	226 / 226	97%	21.08	395 / 406
stomach	100%	596.59	358 / 359	98%	23.48	279 / 286
esophagus	100%	854.49	1445 / 1445	97%	17.23	178 / 183
bladder	100%	740.24	21 / 21	97%	28.82	490 / 504
skin	99%	592.85	1798 / 1809	97%	21.14	458 / 472
lung	99%	540.94	571 / 578	96%	22.12	1110 / 1155
uterus	100%	691.38	170 / 170	95%	28.95	435 / 459
breast	100%	657.77	459 / 459	94%	15.66	1055 / 1118
pancreas	96%	325.30	315 / 328	97%	23.43	173 / 178
lymph node	0%	0	0 / 0	100%	34.62	29 / 29
muscle	100%	3674.84	803 / 803	0%	0	0 / 0
spleen	100%	578.28	241 / 241	0%	0	0 / 0
ureter	0%	0	0 / 0	100%	32.58	1 / 1
adipose	100%	728.89	1202 / 1204	0%	0	0 / 0
heart	100%	1570.56	858 / 861	0%	0	0 / 0
blood vessel	99%	742.23	1327 / 1335	0%	0	0 / 0
eye	0%	0	0 / 0	99%	29.39	79 / 80
tonsil	0%	0	0 / 0	98%	24.32	44 / 45
peripheral blood	50%	229.26	462 / 929	0%	0	0 / 0
abdomen	0%	0	0 / 0	0%	0	0 / 0
bone marrow	0%	0	0 / 0	0%	0	0 / 0
diaphragm	0%	0	0 / 0	0%	0	0 / 0
gingiva	0%	0	0 / 0	0%	0	0 / 0
nasal cavity	0%	0	0 / 0	0%	0	0 / 0
nasopharynx	0%	0	0 / 0	0%	0	0 / 0
nose	0%	0	0 / 0	0%	0	0 / 0
placenta	0%	0	0 / 0	0%	0	0 / 0
spinal column	0%	0	0 / 0	0%	0	0 / 0

III. Associated gene sets

GO_0044255	Biological process	cellular lipid metabolic process
GO_0070328	Biological process	triglyceride homeostasis
GO_0006635	Biological process	fatty acid beta-oxidation
GO_0051146	Biological process	striated muscle cell differentiation
GO_0045333	Biological process	cellular respiration
GO_0010918	Biological process	positive regulation of mitochondrial membrane potential
GO_0051284	Biological process	positive regulation of sequestering of calcium ion
GO_0031334	Biological process	positive regulation of protein-containing complex assembly
GO_0032000	Biological process	positive regulation of fatty acid beta-oxidation
GO_0005743	Cellular component	mitochondrial inner membrane
GO_0005739	Cellular component	mitochondrion
GO_0005515	Molecular function	protein binding

IV. Literature review

[source]

Gene name	MTLN
Protein name	Mitoregulin (Micropeptide in mitochondria) (Micropeptide regulator of beta-oxidation) (Small integral membrane protein 37) (lncRNA-encoded micropeptide)
Synonyms	LINC00116 SMIM37 NCRNA00116 MOXI LEMP MPM
Description	FUNCTION: Positively regulates mitochondrial complex assembly and/or stability (By similarity). Increases mitochondrial membrane potential while decreasing mitochondrial reactive oxygen species . Increases mitochondrial respiration rate . Increased mitochondrial respiratory activity promotes myogenic differentiation which facilitates muscle growth and regeneration (By similarity). Increases mitochondrial calcium retention capacity . Plays a role in maintenance of cellular lipid composition through its interaction with cytochrome b5 reductase CYB5R3 which is required for mitochondrial respiratory complex I activity (By similarity). Interacts with the mitochondrial trifunctional enzyme complex (MTE) and enhances fatty acid beta-oxidation . Not required for MTE formation or stability (By similarity). Modulates triglyceride clearance in adipocytes through its role in regulating fatty acid beta-oxidation and lipolysis . .
Accessions	Q8NCU8 ENST00000414416.2 [Q8NCU8-1] ENST00000426713.1 [Q8NCU8-2] ENST00000611969.5 [Q8NCU8-2]

MTLN report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

IV. Literature review