MSH2 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0048298Biological processpositive regulation of isotype switching to IgA isotypes
GO_0006281Biological processDNA repair
GO_0006119Biological processoxidative phosphorylation
GO_0010165Biological processresponse to X-ray
GO_0001701Biological processin utero embryonic development
GO_0008340Biological processdetermination of adult lifespan
GO_0006302Biological processdouble-strand break repair
GO_0042771Biological processintrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator
GO_0006301Biological processpostreplication repair
GO_0010224Biological processresponse to UV-B
GO_0016447Biological processsomatic recombination of immunoglobulin gene segments
GO_0007281Biological processgerm cell development
GO_0048304Biological processpositive regulation of isotype switching to IgG isotypes
GO_0071168Biological processprotein localization to chromatin
GO_0008584Biological processmale gonad development
GO_0051096Biological processpositive regulation of helicase activity
GO_0031573Biological processmitotic intra-S DNA damage checkpoint signaling
GO_0045190Biological processisotype switching
GO_0016446Biological processsomatic hypermutation of immunoglobulin genes
GO_0006298Biological processmismatch repair
GO_0006312Biological processmitotic recombination
GO_0019724Biological processB cell mediated immunity
GO_0043570Biological processmaintenance of DNA repeat elements
GO_0043524Biological processnegative regulation of neuron apoptotic process
GO_0002204Biological processsomatic recombination of immunoglobulin genes involved in immune response
GO_0030183Biological processB cell differentiation
GO_0045910Biological processnegative regulation of DNA recombination
GO_0016020Cellular componentmembrane
GO_0032302Cellular componentMutSbeta complex
GO_0005654Cellular componentnucleoplasm
GO_0032301Cellular componentMutSalpha complex
GO_0000781Cellular componentchromosome, telomeric region
GO_0005634Cellular componentnucleus
GO_0003677Molecular functionDNA binding
GO_0042803Molecular functionprotein homodimerization activity
GO_0043531Molecular functionADP binding
GO_0032142Molecular functionsingle guanine insertion binding
GO_0003682Molecular functionchromatin binding
GO_0003697Molecular functionsingle-stranded DNA binding
GO_0140664Molecular functionATP-dependent DNA damage sensor activity
GO_0003690Molecular functiondouble-stranded DNA binding
GO_0032181Molecular functiondinucleotide repeat insertion binding
GO_0032137Molecular functionguanine/thymine mispair binding
GO_0032405Molecular functionMutLalpha complex binding
GO_0030983Molecular functionmismatched DNA binding
GO_0000287Molecular functionmagnesium ion binding
GO_0000400Molecular functionfour-way junction DNA binding
GO_0032143Molecular functionsingle thymine insertion binding
GO_0032139Molecular functiondinucleotide insertion or deletion binding
GO_0005524Molecular functionATP binding
GO_0019237Molecular functioncentromeric DNA binding
GO_0008094Molecular functionATP-dependent activity, acting on DNA
GO_0032357Molecular functionoxidized purine DNA binding
GO_0005515Molecular functionprotein binding
GO_0016887Molecular functionATP hydrolysis activity

IV. Literature review

[source]
Gene nameMSH2
Protein nameMutS homolog 2
MSH2+ins9a isoform
Truncated mutS homolog 2 protein
DNA mismatch repair protein
DNA mismatch repair protein Msh2 (hMSH2) (MutS protein homolog 2)
MutS homolog 2 protein
MSH2-Ex10 isoform
MSH2-Ex3 isoform
Uncharacterized protein MSH2
Mutant mismatch repair protein
MSH2-Ex5 isoform
MSH2 protein
SynonymshCG_17836
DescriptionFUNCTION: Component of the post-replicative DNA mismatch repair system (MMR). Forms two different heterodimers: MutS alpha (MSH2-MSH6 heterodimer) and MutS beta (MSH2-MSH3 heterodimer) which binds to DNA mismatches thereby initiating DNA repair. When bound, heterodimers bend the DNA helix and shields approximately 20 base pairs. MutS alpha recognizes single base mismatches and dinucleotide insertion-deletion loops (IDL) in the DNA. MutS beta recognizes larger insertion-deletion loops up to 13 nucleotides long. After mismatch binding, MutS alpha or beta forms a ternary complex with the MutL alpha heterodimer, which is thought to be responsible for directing the downstream MMR events, including strand discrimination, excision, and resynthesis. Recruits DNA helicase MCM9 to chromatin which unwinds the mismatch containing DNA strand . ATP binding and hydrolysis play a pivotal role in mismatch repair functions. The ATPase activity associated with MutS alpha regulates binding similar to a molecular switch: mismatched DNA provokes ADP-->ATP exchange, resulting in a discernible conformational transition that converts MutS alpha into a sliding clamp capable of hydrolysis-independent diffusion along the DNA backbone. This transition is crucial for mismatch repair. MutS alpha may also play a role in DNA homologous recombination repair. In melanocytes may modulate both UV-B-induced cell cycle regulation and apoptosis. .

FUNCTION: Component of the post-replicative DNA mismatch repair system (MMR). .

FUNCTION: Component of the post-replicative DNA mismatch repair system (MMR). .

FUNCTION: Component of the post-replicative DNA mismatch repair system (MMR). .

FUNCTION: Component of the post-replicative DNA mismatch repair system (MMR). .

FUNCTION: Component of the post-replicative DNA mismatch repair system (MMR). .

FUNCTION: Component of the post-replicative DNA mismatch repair system (MMR). .

AccessionsA5JTU9
A0A2R8Y713
A0A2R8YFH0
Q0ZAJ1
V9H0D5
Q53RU4
ENST00000645339.1
Q6VBB7
V9H019
Q0ZAJ2
V9H015
A0A2R8Y7S8
ENST00000646415.1
A5JTV3
Q0ZAJ0
ENST00000406134.5
ENST00000645506.1
ENST00000233146.7 [P43246-1]
ENST00000543555.6 [P43246-2]
V9H023
A0A2R8YG02
A0A2R8Y6P0
A5JTV2
ENST00000644092.1
P43246
Q0ZAI9
E9PHA6
V9H0B2
V9H068
ENST00000644900.2