MICAL2 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0019417Biological processsulfur oxidation
GO_0030042Biological processactin filament depolymerization
GO_0001947Biological processheart looping
GO_0007010Biological processcytoskeleton organization
GO_0007507Biological processheart development
GO_0045944Biological processpositive regulation of transcription by RNA polymerase II
GO_0005884Cellular componentactin filament
GO_0005737Cellular componentcytoplasm
GO_0005634Cellular componentnucleus
GO_0051019Molecular functionmitogen-activated protein kinase binding
GO_0071949Molecular functionFAD binding
GO_0016709Molecular functionoxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen
GO_0016491Molecular functionoxidoreductase activity
GO_0004497Molecular functionmonooxygenase activity
GO_0016174Molecular functionNAD(P)H oxidase H2O2-forming activity
GO_0005515Molecular functionprotein binding
GO_0003779Molecular functionactin binding
GO_0046872Molecular functionmetal ion binding

IV. Literature review

[source]
Gene nameMICAL2
Protein nameAlternative protein MICAL2
[F-actin]-monooxygenase MICAL2 (EC 1.14.13.225) (MICAL C-terminal-like protein) (Mical-cL) (Molecule interacting with CasL protein 2) (MICAL-2)
Microtubule associated monooxygenase, calponin and LIM domain containing 2
SynonymsMICALCL
KIAA0750
MICAL2PV2
MICAL2PV1
DescriptionFUNCTION: Methionine monooxygenase that promotes depolymerization of F-actin by mediating oxidation of residues 'Met-44' and 'Met-47' on actin to form methionine-sulfoxide, resulting in actin filament disassembly and preventing repolymerization . Regulates the disassembly of branched actin networks also by oxidizing ARP3B-containing ARP2/3 complexes leading to ARP3B dissociation from the network . Acts as a key regulator of the SRF signaling pathway elicited by nerve growth factor and serum: mediates oxidation and subsequent depolymerization of nuclear actin, leading to increase MKL1/MRTF-A presence in the nucleus and promote SRF:MKL1/MRTF-A-dependent gene transcription. Does not activate SRF:MKL1/MRTF-A through RhoA . .

AccessionsENST00000675839.1 [O94851-3]
E9PNC3
E9PKI3
ENST00000524685.5
ENST00000532420.1
ENST00000683283.1 [O94851-1]
A0A2R8Y771
ENST00000646065.1 [O94851-7]
ENST00000707072.1 [O94851-4]
E9PRG5
ENST00000528931.5 [O94851-6]
O94851
ENST00000533534.2
ENST00000532179.5
L8EAP5
ENST00000526065.1
E9PJB0
E9PL42
ENST00000529028.1
E9PRE0
ENST00000525119.5
ENST00000256194.8 [O94851-1]
ENST00000533389.1
ENST00000646734.1
A0A2R8Y7K9
ENST00000527546.5 [O94851-5]