Name | Number of supported studies | Average coverage | |
---|---|---|---|
endothelial cell | 7 studies | 27% ± 8% | |
macrophage | 7 studies | 24% ± 6% | |
astrocyte | 7 studies | 27% ± 10% | |
oligodendrocyte | 7 studies | 27% ± 6% | |
glutamatergic neuron | 6 studies | 38% ± 21% | |
microglial cell | 6 studies | 23% ± 6% | |
myeloid cell | 5 studies | 19% ± 2% | |
epithelial cell | 5 studies | 31% ± 9% | |
type II pneumocyte | 5 studies | 21% ± 5% | |
GABAergic neuron | 5 studies | 35% ± 17% | |
interneuron | 5 studies | 28% ± 17% | |
CD16-negative, CD56-bright natural killer cell, human | 4 studies | 17% ± 2% | |
type I pneumocyte | 4 studies | 19% ± 3% | |
oligodendrocyte precursor cell | 4 studies | 28% ± 8% | |
B cell | 3 studies | 19% ± 2% | |
classical monocyte | 3 studies | 30% ± 6% | |
non-classical monocyte | 3 studies | 32% ± 12% | |
ciliated cell | 3 studies | 23% ± 1% | |
lymphocyte | 3 studies | 18% ± 2% | |
dendritic cell | 3 studies | 32% ± 13% | |
abnormal cell | 3 studies | 23% ± 6% | |
fibroblast | 3 studies | 17% ± 2% | |
goblet cell | 3 studies | 25% ± 12% | |
neuron | 3 studies | 29% ± 10% |
Tissue | GTEx Coverage | GTEx Average TPM | GTEx Number of samples | TCGA Coverage | TCGA Average TPM | TCGA Number of samples |
---|---|---|---|---|---|---|
esophagus | 100% | 5121.81 | 1445 / 1445 | 100% | 34.44 | 183 / 183 |
intestine | 100% | 5949.83 | 966 / 966 | 100% | 34.46 | 527 / 527 |
ovary | 100% | 6290.03 | 180 / 180 | 100% | 36.88 | 430 / 430 |
stomach | 100% | 5518.55 | 359 / 359 | 100% | 36.84 | 286 / 286 |
thymus | 100% | 6494.59 | 653 / 653 | 100% | 40.59 | 604 / 605 |
prostate | 100% | 6721.61 | 245 / 245 | 100% | 34.11 | 501 / 502 |
skin | 100% | 4448.73 | 1808 / 1809 | 100% | 48.21 | 471 / 472 |
kidney | 100% | 4430.79 | 89 / 89 | 100% | 43.19 | 897 / 901 |
brain | 100% | 7174.74 | 2633 / 2642 | 100% | 39.98 | 704 / 705 |
pancreas | 100% | 3528.00 | 328 / 328 | 99% | 28.61 | 177 / 178 |
breast | 100% | 4888.64 | 459 / 459 | 99% | 36.26 | 1111 / 1118 |
adrenal gland | 100% | 6420.55 | 258 / 258 | 99% | 26.33 | 228 / 230 |
lung | 100% | 6554.12 | 578 / 578 | 99% | 31.50 | 1144 / 1155 |
bladder | 100% | 5512.52 | 21 / 21 | 99% | 25.03 | 498 / 504 |
uterus | 100% | 7270.16 | 170 / 170 | 98% | 23.14 | 452 / 459 |
liver | 100% | 5668.36 | 226 / 226 | 98% | 22.27 | 396 / 406 |
adipose | 100% | 4733.09 | 1204 / 1204 | 0% | 0 | 0 / 0 |
eye | 0% | 0 | 0 / 0 | 100% | 53.33 | 80 / 80 |
lymph node | 0% | 0 | 0 / 0 | 100% | 23.71 | 29 / 29 |
muscle | 100% | 5378.55 | 803 / 803 | 0% | 0 | 0 / 0 |
spleen | 100% | 8065.84 | 241 / 241 | 0% | 0 | 0 / 0 |
ureter | 0% | 0 | 0 / 0 | 100% | 17.40 | 1 / 1 |
blood vessel | 100% | 5587.50 | 1334 / 1335 | 0% | 0 | 0 / 0 |
peripheral blood | 99% | 8417.76 | 918 / 929 | 0% | 0 | 0 / 0 |
heart | 98% | 3527.78 | 842 / 861 | 0% | 0 | 0 / 0 |
tonsil | 0% | 0 | 0 / 0 | 98% | 17.17 | 44 / 45 |
abdomen | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
bone marrow | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
diaphragm | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
gingiva | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
nasal cavity | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
nasopharynx | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
nose | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
placenta | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
spinal column | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
GO_0016567 | Biological process | protein ubiquitination |
GO_0000209 | Biological process | protein polyubiquitination |
GO_0045879 | Biological process | negative regulation of smoothened signaling pathway |
GO_0045744 | Biological process | negative regulation of G protein-coupled receptor signaling pathway |
GO_0008333 | Biological process | endosome to lysosome transport |
GO_0043951 | Biological process | negative regulation of cAMP-mediated signaling |
GO_0006513 | Biological process | protein monoubiquitination |
GO_0005886 | Cellular component | plasma membrane |
GO_0016020 | Cellular component | membrane |
GO_0005769 | Cellular component | early endosome |
GO_0070062 | Cellular component | extracellular exosome |
GO_0005783 | Cellular component | endoplasmic reticulum |
GO_0005829 | Cellular component | cytosol |
GO_0005737 | Cellular component | cytoplasm |
GO_0043231 | Cellular component | intracellular membrane-bounded organelle |
GO_0005634 | Cellular component | nucleus |
GO_0061630 | Molecular function | ubiquitin protein ligase activity |
GO_0046872 | Molecular function | metal ion binding |
GO_0004842 | Molecular function | ubiquitin-protein transferase activity |
GO_0005515 | Molecular function | protein binding |
Gene name | MGRN1 |
Protein name | E3 ubiquitin-protein ligase MGRN1 (EC 2.3.2.27) (Mahogunin RING finger protein 1) (RING finger protein 156) (RING-type E3 ubiquitin transferase MGRN1) E3 ubiquitin-protein ligase (EC 2.3.2.27) (RING-type E3 ubiquitin transferase) |
Synonyms | KIAA0544 RNF156 |
Description | FUNCTION: E3 ubiquitin-protein ligase. Mediates monoubiquitination at multiple sites of TSG101 in the presence of UBE2D1, but not of UBE2G1, nor UBE2H. Plays a role in the regulation of endosome-to-lysosome trafficking. Impairs MC1R- and MC4R-signaling by competing with GNAS-binding to MCRs and inhibiting agonist-induced cAMP production. Does not inhibit ADRB2-signaling. Does not promote MC1R ubiquitination. Acts also as a negative regulator of hedgehog signaling (By similarity). . FUNCTION: E3 ubiquitin ligase. . FUNCTION: E3 ubiquitin ligase. . FUNCTION: E3 ubiquitin ligase. . FUNCTION: E3 ubiquitin ligase. . FUNCTION: E3 ubiquitin ligase. . |
Accessions | ENST00000399577.9 [O60291-1] O60291 ENST00000586183.5 [O60291-4] ENST00000536343.5 K7EJN3 K7EPJ5 ENST00000593224.1 K7EIM7 ENST00000415496.5 [O60291-4] ENST00000587747.5 ENST00000262370.12 [O60291-2] B4DR12 ENST00000590790.5 K7ERA1 ENST00000591895.5 ENST00000588994.5 [O60291-3] |