MGRN1 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0016567Biological processprotein ubiquitination
GO_0000209Biological processprotein polyubiquitination
GO_0045879Biological processnegative regulation of smoothened signaling pathway
GO_0045744Biological processnegative regulation of G protein-coupled receptor signaling pathway
GO_0008333Biological processendosome to lysosome transport
GO_0043951Biological processnegative regulation of cAMP-mediated signaling
GO_0006513Biological processprotein monoubiquitination
GO_0005886Cellular componentplasma membrane
GO_0016020Cellular componentmembrane
GO_0005769Cellular componentearly endosome
GO_0070062Cellular componentextracellular exosome
GO_0005783Cellular componentendoplasmic reticulum
GO_0005829Cellular componentcytosol
GO_0005737Cellular componentcytoplasm
GO_0043231Cellular componentintracellular membrane-bounded organelle
GO_0005634Cellular componentnucleus
GO_0061630Molecular functionubiquitin protein ligase activity
GO_0046872Molecular functionmetal ion binding
GO_0004842Molecular functionubiquitin-protein transferase activity
GO_0005515Molecular functionprotein binding

IV. Literature review

[source]
Gene nameMGRN1
Protein nameE3 ubiquitin-protein ligase MGRN1 (EC 2.3.2.27) (Mahogunin RING finger protein 1) (RING finger protein 156) (RING-type E3 ubiquitin transferase MGRN1)
E3 ubiquitin-protein ligase (EC 2.3.2.27) (RING-type E3 ubiquitin transferase)
SynonymsKIAA0544
RNF156
DescriptionFUNCTION: E3 ubiquitin-protein ligase. Mediates monoubiquitination at multiple sites of TSG101 in the presence of UBE2D1, but not of UBE2G1, nor UBE2H. Plays a role in the regulation of endosome-to-lysosome trafficking. Impairs MC1R- and MC4R-signaling by competing with GNAS-binding to MCRs and inhibiting agonist-induced cAMP production. Does not inhibit ADRB2-signaling. Does not promote MC1R ubiquitination. Acts also as a negative regulator of hedgehog signaling (By similarity). .

FUNCTION: E3 ubiquitin ligase. .

FUNCTION: E3 ubiquitin ligase. .

FUNCTION: E3 ubiquitin ligase. .

FUNCTION: E3 ubiquitin ligase. .

FUNCTION: E3 ubiquitin ligase. .

AccessionsENST00000399577.9 [O60291-1]
O60291
ENST00000586183.5 [O60291-4]
ENST00000536343.5
K7EJN3
K7EPJ5
ENST00000593224.1
K7EIM7
ENST00000415496.5 [O60291-4]
ENST00000587747.5
ENST00000262370.12 [O60291-2]
B4DR12
ENST00000590790.5
K7ERA1
ENST00000591895.5
ENST00000588994.5 [O60291-3]