MED30 | OmnibusX

I. Expression across cell types

Name	Number of supported studies	Average coverage
natural killer cell	15 studies	22% ± 6%	Explore
B cell	13 studies	22% ± 7%	Explore
plasmacytoid dendritic cell	10 studies	26% ± 9%	Explore
CD16-negative, CD56-bright natural killer cell, human	9 studies	22% ± 4%	Explore
naive B cell	9 studies	22% ± 4%	Explore
CD8-positive, alpha-beta T cell	9 studies	20% ± 5%	Explore
CD16-positive, CD56-dim natural killer cell, human	8 studies	20% ± 3%	Explore
fibroblast	8 studies	19% ± 4%	Explore
CD4-positive, alpha-beta T cell	7 studies	22% ± 5%	Explore
mature NK T cell	7 studies	18% ± 1%	Explore
mucosal invariant T cell	7 studies	21% ± 4%	Explore
memory B cell	6 studies	19% ± 3%	Explore
ciliated cell	6 studies	30% ± 11%	Explore
gamma-delta T cell	6 studies	24% ± 13%	Explore
effector memory CD8-positive, alpha-beta T cell	5 studies	20% ± 5%	Explore
regulatory T cell	5 studies	19% ± 5%	Explore
naive thymus-derived CD4-positive, alpha-beta T cell	4 studies	20% ± 4%	Explore
precursor B cell	4 studies	33% ± 10%	Explore
pro-B cell	4 studies	31% ± 5%	Explore
pericyte	4 studies	19% ± 3%	Explore
epithelial cell	4 studies	34% ± 12%	Explore
endothelial cell	4 studies	25% ± 6%	Explore
basal cell	4 studies	23% ± 8%	Explore
CD8-positive, alpha-beta memory T cell	4 studies	21% ± 2%	Explore
classical monocyte	3 studies	22% ± 3%	Explore
conventional dendritic cell	3 studies	31% ± 11%	Explore
non-classical monocyte	3 studies	25% ± 6%	Explore
immature B cell	3 studies	25% ± 1%	Explore
glutamatergic neuron	3 studies	20% ± 4%	Explore
dendritic cell	3 studies	35% ± 14%	Explore
group 3 innate lymphoid cell	3 studies	31% ± 10%	Explore
innate lymphoid cell	3 studies	20% ± 3%	Explore
CD4-positive, alpha-beta memory T cell	3 studies	20% ± 3%	Explore
T cell	3 studies	19% ± 4%	Explore

II. Expression across tissues

Name	Number of supported studies	Average coverage
peripheral blood	6 studies	23% ± 7%	Explore
lung	3 studies	22% ± 5%	Explore

Tissue	GTEx Coverage	GTEx Average TPM	GTEx Number of samples	TCGA Coverage	TCGA Average TPM	TCGA Number of samples
esophagus	100%	544.13	1445 / 1445	100%	35.05	183 / 183
ovary	100%	825.12	180 / 180	100%	47.60	430 / 430
stomach	100%	384.60	359 / 359	100%	32.64	286 / 286
lung	100%	570.25	577 / 578	100%	30.52	1154 / 1155
breast	100%	767.24	459 / 459	100%	26.67	1114 / 1118
intestine	100%	577.79	966 / 966	100%	32.82	525 / 527
brain	100%	333.21	2629 / 2642	100%	22.45	705 / 705
uterus	100%	759.84	170 / 170	99%	34.07	456 / 459
bladder	100%	571.86	21 / 21	99%	30.48	499 / 504
prostate	100%	517.20	245 / 245	99%	16.61	496 / 502
thymus	100%	570.87	653 / 653	98%	24.05	595 / 605
liver	100%	285.46	225 / 226	98%	17.63	399 / 406
pancreas	97%	217.59	317 / 328	99%	19.71	177 / 178
skin	100%	618.71	1809 / 1809	94%	13.97	442 / 472
adrenal gland	100%	314.27	258 / 258	93%	11.05	215 / 230
kidney	99%	314.43	88 / 89	91%	11.18	824 / 901
adipose	100%	731.55	1204 / 1204	0%	0	0 / 0
blood vessel	100%	713.65	1335 / 1335	0%	0	0 / 0
lymph node	0%	0	0 / 0	100%	38.45	29 / 29
spleen	100%	587.18	241 / 241	0%	0	0 / 0
tonsil	0%	0	0 / 0	100%	31.77	45 / 45
ureter	0%	0	0 / 0	100%	16.00	1 / 1
heart	99%	283.02	851 / 861	0%	0	0 / 0
muscle	98%	248.96	784 / 803	0%	0	0 / 0
peripheral blood	97%	535.92	897 / 929	0%	0	0 / 0
eye	0%	0	0 / 0	90%	12.98	72 / 80
abdomen	0%	0	0 / 0	0%	0	0 / 0
bone marrow	0%	0	0 / 0	0%	0	0 / 0
diaphragm	0%	0	0 / 0	0%	0	0 / 0
gingiva	0%	0	0 / 0	0%	0	0 / 0
nasal cavity	0%	0	0 / 0	0%	0	0 / 0
nasopharynx	0%	0	0 / 0	0%	0	0 / 0
nose	0%	0	0 / 0	0%	0	0 / 0
placenta	0%	0	0 / 0	0%	0	0 / 0
spinal column	0%	0	0 / 0	0%	0	0 / 0

III. Associated gene sets

GO_0051123	Biological process	RNA polymerase II preinitiation complex assembly
GO_0016567	Biological process	protein ubiquitination
GO_0060261	Biological process	positive regulation of transcription initiation by RNA polymerase II
GO_0045893	Biological process	positive regulation of DNA-templated transcription
GO_0032968	Biological process	positive regulation of transcription elongation by RNA polymerase II
GO_0035019	Biological process	somatic stem cell population maintenance
GO_0000151	Cellular component	ubiquitin ligase complex
GO_0016592	Cellular component	mediator complex
GO_0005654	Cellular component	nucleoplasm
GO_0070847	Cellular component	core mediator complex
GO_0005634	Cellular component	nucleus
GO_0046966	Molecular function	nuclear thyroid hormone receptor binding
GO_0061630	Molecular function	ubiquitin protein ligase activity
GO_0003713	Molecular function	transcription coactivator activity
GO_0042809	Molecular function	nuclear vitamin D receptor binding
GO_0030374	Molecular function	nuclear receptor coactivator activity
GO_0005515	Molecular function	protein binding
GO_0003712	Molecular function	transcription coregulator activity

IV. Literature review

[source]

Gene name	MED30
Protein name	Mediator of RNA polymerase II transcription subunit 30 (Mediator complex subunit 30) (TRAP/Mediator complex component TRAP25) (Thyroid hormone receptor-associated protein 6) (Thyroid hormone receptor-associated protein complex 25 kDa component) (Trap25)
Synonyms	THRAP6 TRAP25
Description	FUNCTION: Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. .
Accessions	ENST00000522839.1 [Q96HR3-2] ENST00000297347.7 [Q96HR3-1] Q96HR3

MED30 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

IV. Literature review