MED12 report

I. Expression across cell types

Insufficient scRNA-seq data for expression of MED12 at single-cell level.

II. Expression across tissues

sc-RNAseq data

Insufficient scRNA-seq data for expression of MED12 at tissue level.

III. Associated gene sets

GO_0014003Biological processoligodendrocyte development
GO_0016567Biological processprotein ubiquitination
GO_0090245Biological processaxis elongation involved in somitogenesis
GO_0021510Biological processspinal cord development
GO_0007507Biological processheart development
GO_0060261Biological processpositive regulation of transcription initiation by RNA polymerase II
GO_0007492Biological processendoderm development
GO_0014044Biological processSchwann cell development
GO_0045893Biological processpositive regulation of DNA-templated transcription
GO_0036342Biological processpost-anal tail morphogenesis
GO_0001843Biological processneural tube closure
GO_0048702Biological processembryonic neurocranium morphogenesis
GO_0060071Biological processWnt signaling pathway, planar cell polarity pathway
GO_1990403Biological processembryonic brain development
GO_0045944Biological processpositive regulation of transcription by RNA polymerase II
GO_0035019Biological processsomatic stem cell population maintenance
GO_0000151Cellular componentubiquitin ligase complex
GO_0016592Cellular componentmediator complex
GO_0016020Cellular componentmembrane
GO_0005654Cellular componentnucleoplasm
GO_1990508Cellular componentCKM complex
GO_0005634Cellular componentnucleus
GO_0008134Molecular functiontranscription factor binding
GO_0046966Molecular functionnuclear thyroid hormone receptor binding
GO_0061630Molecular functionubiquitin protein ligase activity
GO_0000978Molecular functionRNA polymerase II cis-regulatory region sequence-specific DNA binding
GO_0003682Molecular functionchromatin binding
GO_0008013Molecular functionbeta-catenin binding
GO_0003712Molecular functiontranscription coregulator activity
GO_0003713Molecular functiontranscription coactivator activity
GO_0042809Molecular functionnuclear vitamin D receptor binding
GO_0030374Molecular functionnuclear receptor coactivator activity
GO_0005515Molecular functionprotein binding

IV. Literature review

[source]
Gene nameMED12
Protein nameMediator of RNA polymerase II transcription, subunit 12 homolog (Yeast), isoform CRA_e (TNRC11 protein)
Mediator complex subunit 12
Mediator of RNA polymerase II transcription subunit 12 (Activator-recruited cofactor 240 kDa component) (ARC240) (CAG repeat protein 45) (Mediator complex subunit 12) (OPA-containing protein) (Thyroid hormone receptor-associated protein complex 230 kDa component) (Trap230) (Trinucleotide repeat-containing gene 11 protein)
SynonymshCG_19960
TNRC11
CAGH45
KIAA0192
TRAP230
ARC240
HOPA
DescriptionFUNCTION: Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional pre-initiation complex with RNA polymerase II and the general transcription factors. This subunit may specifically regulate transcription of targets of the Wnt signaling pathway and SHH signaling pathway. .

AccessionsA0A8I5KQ51
ENST00000693391.1
A0A8I5KWE2
A0A8I5KVC2
A0A8I5QJW8
ENST00000333646.11
ENST00000444034.2
ENST00000688774.1
H7C274
A0A8I5KVM1
ENST00000690690.1
ENST00000685789.1
A0A8I5KVA6
A0A0A0MR79
A0A8I5KWM7
ENST00000685655.1
H7C191
A0A8I5KQY2
ENST00000687382.1
A0A8I5KXK9
A0A8I5KUR0
ENST00000688663.1
ENST00000689008.1
Q93074
ENST00000692864.1
A0A8I5KSA4
ENST00000688231.1
ENST00000692304.1 [Q93074-3]
ENST00000374080.8 [Q93074-1]
ENST00000690807.1
ENST00000693324.1
A0A8I5QJG1
ENST00000374102.6 [Q93074-2]
A0A8I5KW86
ENST00000690878.1
ENST00000691468.1
A0A8I5KRJ8
ENST00000429213.3
ENST00000691113.1
Q7Z3Z5
A0A8I5QJB1
ENST00000690145.1
ENST00000686548.1
A0A8I5QKU5
A0A8I5QJK7
ENST00000690242.1
ENST00000489199.2
ENST00000691283.1
A0A8I5KVJ2