MDFIC report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0050434Biological processpositive regulation of viral transcription
GO_0042308Biological processnegative regulation of protein import into nucleus
GO_0046328Biological processregulation of JNK cascade
GO_0045893Biological processpositive regulation of DNA-templated transcription
GO_0030111Biological processregulation of Wnt signaling pathway
GO_0045892Biological processnegative regulation of DNA-templated transcription
GO_0005730Cellular componentnucleolus
GO_0005576Cellular componentextracellular region
GO_0005886Cellular componentplasma membrane
GO_0005737Cellular componentcytoplasm
GO_0005634Cellular componentnucleus
GO_0008134Molecular functiontranscription factor binding
GO_0140297Molecular functionDNA-binding transcription factor binding
GO_0030957Molecular functionTat protein binding
GO_0005515Molecular functionprotein binding
GO_0030332Molecular functioncyclin binding

IV. Literature review

[source]
Gene nameMDFIC
Protein nameMyoD family inhibitor domain containing
MyoD family inhibitor domain-containing protein (I-mfa domain-containing protein) (hIC)
Synonyms
DescriptionFUNCTION: Required to control the activity of various transcription factors through their sequestration in the cytoplasm. Retains nuclear Zic proteins ZIC1, ZIC2 and ZIC3 in the cytoplasm and inhibits their transcriptional activation (By similarity). Modulates the expression from both cellular and viral promoters. Down-regulates Tat-dependent transcription of the human immunodeficiency virus type 1 (HIV-1) LTR by interacting with HIV-1 Tat and Rev and impairing their nuclear import, probably by rendering the NLS domains inaccessible to importin-beta . Also stimulates activation of human T-cell leukemia virus type I (HTLV-I) LTR . Binds to the axin complex, resulting in an increase in the level of free beta-catenin . Affects axin regulation of the WNT and JNK signaling pathways . Has a role in the development of lymphatic vessel valves. It is required to promote lymphatic endothelial cell migration, in a process that involves down-regulation of integrin beta 1 activation and control of cell adhesion to the extracellular matrix (By similarity). .

AccessionsENST00000393486.6 [Q9P1T7-2]
ENST00000427207.5
ENST00000431629.5
H7BZY3
C9J104
ENST00000498196.1
ENST00000423503.1
C9J784
H7C4B9
ENST00000448022.1
Q9P1T7