LPIN2 | OmnibusX

I. Expression across cell types

Name	Number of supported studies	Average coverage
CD4-positive, alpha-beta T cell	16 studies	21% ± 4%	Explore
T cell	13 studies	22% ± 7%	Explore
natural killer cell	12 studies	19% ± 3%	Explore
microglial cell	12 studies	42% ± 16%	Explore
type I pneumocyte	10 studies	31% ± 8%	Explore
CD8-positive, alpha-beta T cell	10 studies	20% ± 4%	Explore
macrophage	10 studies	27% ± 12%	Explore
CD8-positive, alpha-beta memory T cell	9 studies	19% ± 4%	Explore
naive thymus-derived CD4-positive, alpha-beta T cell	9 studies	20% ± 3%	Explore
endothelial cell	9 studies	28% ± 10%	Explore
astrocyte	9 studies	33% ± 13%	Explore
mature NK T cell	8 studies	21% ± 6%	Explore
mucosal invariant T cell	8 studies	21% ± 3%	Explore
endothelial cell of lymphatic vessel	7 studies	18% ± 4%	Explore
GABAergic neuron	7 studies	39% ± 18%	Explore
gamma-delta T cell	7 studies	23% ± 6%	Explore
leukocyte	6 studies	26% ± 14%	Explore
CD16-negative, CD56-bright natural killer cell, human	6 studies	18% ± 2%	Explore
effector memory CD8-positive, alpha-beta T cell	6 studies	21% ± 3%	Explore
myeloid cell	6 studies	22% ± 6%	Explore
regulatory T cell	6 studies	17% ± 2%	Explore
oligodendrocyte precursor cell	6 studies	27% ± 9%	Explore
glutamatergic neuron	5 studies	37% ± 20%	Explore
CD16-positive, CD56-dim natural killer cell, human	5 studies	17% ± 3%	Explore
epithelial cell	5 studies	28% ± 6%	Explore
dendritic cell	5 studies	20% ± 6%	Explore
CD4-positive, alpha-beta memory T cell	5 studies	19% ± 4%	Explore
effector memory CD4-positive, alpha-beta T cell	5 studies	20% ± 6%	Explore
hepatocyte	5 studies	53% ± 26%	Explore
type II pneumocyte	5 studies	25% ± 5%	Explore
erythrocyte	5 studies	37% ± 18%	Explore
interneuron	5 studies	39% ± 21%	Explore
oligodendrocyte	5 studies	24% ± 7%	Explore
ciliated cell	4 studies	24% ± 10%	Explore
lymphocyte	4 studies	31% ± 10%	Explore
monocyte	4 studies	26% ± 11%	Explore
club cell	4 studies	25% ± 7%	Explore
fibroblast	4 studies	22% ± 6%	Explore
abnormal cell	3 studies	28% ± 12%	Explore
neuron	3 studies	23% ± 11%	Explore
GABAergic interneuron	3 studies	23% ± 3%	Explore
retina horizontal cell	3 studies	24% ± 4%	Explore
ependymal cell	3 studies	33% ± 11%	Explore
T follicular helper cell	3 studies	21% ± 1%	Explore
group 3 innate lymphoid cell	3 studies	22% ± 4%	Explore

II. Expression across tissues

Name	Number of supported studies	Average coverage
brain	10 studies	27% ± 12%	Explore
lung	5 studies	20% ± 4%	Explore
liver	4 studies	32% ± 11%	Explore
peripheral blood	3 studies	19% ± 2%	Explore

Tissue	GTEx Coverage	GTEx Average TPM	GTEx Number of samples	TCGA Coverage	TCGA Average TPM	TCGA Number of samples
stomach	100%	3382.30	359 / 359	100%	35.04	286 / 286
brain	100%	4503.14	2639 / 2642	100%	41.67	705 / 705
liver	100%	11435.58	226 / 226	99%	67.82	403 / 406
intestine	100%	3298.29	966 / 966	99%	30.22	523 / 527
thymus	100%	2959.03	652 / 653	99%	28.01	598 / 605
kidney	100%	4903.02	89 / 89	98%	30.23	887 / 901
ovary	100%	3138.84	180 / 180	98%	23.00	420 / 430
prostate	100%	2334.29	244 / 245	98%	22.47	492 / 502
breast	100%	2722.58	459 / 459	97%	26.37	1087 / 1118
lung	100%	4692.63	578 / 578	96%	41.01	1107 / 1155
pancreas	98%	1965.36	321 / 328	97%	38.19	172 / 178
adrenal gland	100%	2181.14	258 / 258	89%	18.06	205 / 230
esophagus	97%	1931.89	1398 / 1445	90%	37.21	164 / 183
skin	89%	1945.05	1601 / 1809	95%	24.73	450 / 472
uterus	100%	2769.05	170 / 170	84%	18.54	384 / 459
bladder	100%	2817.48	21 / 21	82%	20.80	413 / 504
adipose	100%	2962.60	1204 / 1204	0%	0	0 / 0
spleen	100%	4295.60	241 / 241	0%	0	0 / 0
blood vessel	100%	3563.48	1334 / 1335	0%	0	0 / 0
peripheral blood	99%	4210.76	922 / 929	0%	0	0 / 0
lymph node	0%	0	0 / 0	97%	30.66	28 / 29
heart	86%	1161.36	743 / 861	0%	0	0 / 0
eye	0%	0	0 / 0	85%	13.20	68 / 80
tonsil	0%	0	0 / 0	80%	20.70	36 / 45
muscle	24%	197.66	193 / 803	0%	0	0 / 0
abdomen	0%	0	0 / 0	0%	0	0 / 0
bone marrow	0%	0	0 / 0	0%	0	0 / 0
diaphragm	0%	0	0 / 0	0%	0	0 / 0
gingiva	0%	0	0 / 0	0%	0	0 / 0
nasal cavity	0%	0	0 / 0	0%	0	0 / 0
nasopharynx	0%	0	0 / 0	0%	0	0 / 0
nose	0%	0	0 / 0	0%	0	0 / 0
placenta	0%	0	0 / 0	0%	0	0 / 0
spinal column	0%	0	0 / 0	0%	0	0 / 0
ureter	0%	0	0 / 0	0%	0	0 / 1

III. Associated gene sets

GO_0019432	Biological process	triglyceride biosynthetic process
GO_0006629	Biological process	lipid metabolic process
GO_0032869	Biological process	cellular response to insulin stimulus
GO_0009062	Biological process	fatty acid catabolic process
GO_0045944	Biological process	positive regulation of transcription by RNA polymerase II
GO_0005829	Cellular component	cytosol
GO_0005789	Cellular component	endoplasmic reticulum membrane
GO_0005634	Cellular component	nucleus
GO_0008195	Molecular function	phosphatidate phosphatase activity
GO_0003713	Molecular function	transcription coactivator activity

IV. Literature review

[source]

Gene name	LPIN2
Protein name	phosphatidate phosphatase (EC 3.1.3.4) Lipin 2 Phosphatidate phosphatase LPIN2 (EC 3.1.3.4) (Lipin-2)
Synonyms	KIAA0249
Description	FUNCTION: Acts as a magnesium-dependent phosphatidate phosphatase enzyme which catalyzes the conversion of phosphatidic acid to diacylglycerol during triglyceride, phosphatidylcholine and phosphatidylethanolamine biosynthesis in the reticulum endoplasmic membrane. Plays important roles in controlling the metabolism of fatty acids at different levels. Acts also as a nuclear transcriptional coactivator for PPARGC1A to modulate lipid metabolism. .
Accessions	ENST00000697042.1 Q92539 A0A8V8TM42 ENST00000697043.1 A0A8V8TLW1 A0A8V8TKZ9 J3QQN0 A0A8V8TKL8 ENST00000261596.9 ENST00000677752.1 ENST00000697039.1 ENST00000584915.2 ENST00000697040.1 ENST00000697041.1

LPIN2 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

IV. Literature review