LIMCH1 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0030336Biological processnegative regulation of cell migration
GO_0001934Biological processpositive regulation of protein phosphorylation
GO_0060327Biological processcytoplasmic actin-based contraction involved in cell motility
GO_0051893Biological processregulation of focal adhesion assembly
GO_0051496Biological processpositive regulation of stress fiber assembly
GO_0031032Biological processactomyosin structure organization
GO_0001725Cellular componentstress fiber
GO_0016460Cellular componentmyosin II complex
GO_0005737Cellular componentcytoplasm
GO_0032034Molecular functionmyosin II head/neck binding
GO_0003779Molecular functionactin binding
GO_0046872Molecular functionmetal ion binding

IV. Literature review

[source]
Gene nameLIMCH1
Protein nameLIM and calponin homology domains-containing protein 1
LIM and calponin homology domains 1 (LIMCH1 protein)
LIM and calponin homology domains 1
SynonymsKIAA1102
hCG_33090
DKFZP686A01247
DescriptionFUNCTION: Actin stress fibers-associated protein that activates non-muscle myosin IIa. Activates the non-muscle myosin IIa complex by promoting the phosphorylation of its regulatory subunit MRLC/MYL9. Through the activation of non-muscle myosin IIa, positively regulates actin stress fibers assembly and stabilizes focal adhesions. It therefore negatively regulates cell spreading and cell migration. .

AccessionsE9PDJ9
D6RD46
ENST00000381753.8 [Q9UPQ0-9]
ENST00000511424.5
ENST00000508466.1
ENST00000513024.5 [Q9UPQ0-5]
ENST00000509454.5
ENST00000446625.6
D6RJ93
D6RGH8
Q9UPQ0
D6R8Y0
ENST00000511496.5 [Q9UPQ0-8]
ENST00000509277.5
ENST00000514096.5
ENST00000503057.6
H0Y8P3
ENST00000512946.5 [Q9UPQ0-2]
ENST00000508501.5 [Q9UPQ0-10]
ENST00000313860.12 [Q9UPQ0-1]
ENST00000509638.5
ENST00000396595.7 [Q9UPQ0-6]
ENST00000512632.5
E7EPK0
ENST00000512820.5 [Q9UPQ0-4]
G5EA03
Q6NVB9