LILRB4 | OmnibusX

I. Expression across cell types

Name	Number of supported studies	Average coverage
macrophage	23 studies	31% ± 13%	Explore
plasmacytoid dendritic cell	20 studies	63% ± 15%	Explore
classical monocyte	15 studies	25% ± 11%	Explore
conventional dendritic cell	14 studies	32% ± 19%	Explore
non-classical monocyte	13 studies	23% ± 8%	Explore
myeloid cell	9 studies	37% ± 13%	Explore
monocyte	8 studies	34% ± 13%	Explore
dendritic cell	6 studies	41% ± 15%	Explore
microglial cell	5 studies	38% ± 19%	Explore
plasma cell	4 studies	33% ± 7%	Explore
plasmablast	3 studies	31% ± 17%	Explore
intermediate monocyte	3 studies	28% ± 6%	Explore
mononuclear phagocyte	3 studies	25% ± 5%	Explore

II. Expression across tissues

sc-RNAseq data

Insufficient scRNA-seq data for expression of LILRB4 at tissue level.

Tissue	GTEx Coverage	GTEx Average TPM	GTEx Number of samples	TCGA Coverage	TCGA Average TPM	TCGA Number of samples
lung	99%	1313.07	574 / 578	88%	16.20	1017 / 1155
breast	81%	338.50	372 / 459	92%	13.34	1033 / 1118
brain	64%	315.37	1682 / 2642	95%	22.63	671 / 705
intestine	87%	363.75	837 / 966	60%	6.79	316 / 527
thymus	68%	232.77	446 / 653	62%	5.96	377 / 605
bladder	71%	198.76	15 / 21	58%	7.52	292 / 504
kidney	44%	172.17	39 / 89	83%	11.67	746 / 901
adrenal gland	94%	441.45	243 / 258	23%	1.55	53 / 230
esophagus	58%	184.15	844 / 1445	57%	4.51	104 / 183
stomach	40%	106.51	144 / 359	72%	8.66	205 / 286
prostate	67%	182.93	163 / 245	45%	2.70	227 / 502
pancreas	22%	62.99	73 / 328	79%	8.90	141 / 178
lymph node	0%	0	0 / 0	100%	118.81	29 / 29
spleen	100%	1759.53	241 / 241	0%	0	0 / 0
peripheral blood	100%	2257.51	926 / 929	0%	0	0 / 0
adipose	95%	669.64	1142 / 1204	0%	0	0 / 0
ovary	19%	43.17	34 / 180	75%	8.67	322 / 430
uterus	28%	60.95	47 / 170	58%	6.79	268 / 459
skin	9%	16.50	156 / 1809	76%	15.63	360 / 472
tonsil	0%	0	0 / 0	80%	14.82	36 / 45
liver	46%	150.07	104 / 226	33%	2.72	134 / 406
blood vessel	60%	446.59	801 / 1335	0%	0	0 / 0
heart	47%	122.40	408 / 861	0%	0	0 / 0
eye	0%	0	0 / 0	23%	1.46	18 / 80
muscle	3%	5.87	24 / 803	0%	0	0 / 0
abdomen	0%	0	0 / 0	0%	0	0 / 0
bone marrow	0%	0	0 / 0	0%	0	0 / 0
diaphragm	0%	0	0 / 0	0%	0	0 / 0
gingiva	0%	0	0 / 0	0%	0	0 / 0
nasal cavity	0%	0	0 / 0	0%	0	0 / 0
nasopharynx	0%	0	0 / 0	0%	0	0 / 0
nose	0%	0	0 / 0	0%	0	0 / 0
placenta	0%	0	0 / 0	0%	0	0 / 0
spinal column	0%	0	0 / 0	0%	0	0 / 0
ureter	0%	0	0 / 0	0%	0	0 / 1

III. Associated gene sets

GO_0150102	Biological process	negative regulation of monocyte activation
GO_0019221	Biological process	cytokine-mediated signaling pathway
GO_0045671	Biological process	negative regulation of osteoclast differentiation
GO_0002507	Biological process	tolerance induction
GO_0031623	Biological process	receptor internalization
GO_0002725	Biological process	negative regulation of T cell cytokine production
GO_0045584	Biological process	negative regulation of cytotoxic T cell differentiation
GO_2000272	Biological process	negative regulation of signaling receptor activity
GO_0032703	Biological process	negative regulation of interleukin-2 production
GO_0032715	Biological process	negative regulation of interleukin-6 production
GO_0050860	Biological process	negative regulation of T cell receptor signaling pathway
GO_1902894	Biological process	negative regulation of miRNA transcription
GO_1900016	Biological process	negative regulation of cytokine production involved in inflammatory response
GO_0071659	Biological process	negative regulation of IP-10 production
GO_0032691	Biological process	negative regulation of interleukin-1 beta production
GO_2000524	Biological process	negative regulation of T cell costimulation
GO_0032693	Biological process	negative regulation of interleukin-10 production
GO_0140105	Biological process	interleukin-10-mediated signaling pathway
GO_0002250	Biological process	adaptive immune response
GO_0043378	Biological process	positive regulation of CD8-positive, alpha-beta T cell differentiation
GO_0046007	Biological process	negative regulation of activated T cell proliferation
GO_0042130	Biological process	negative regulation of T cell proliferation
GO_0002764	Biological process	immune response-regulating signaling pathway
GO_0061099	Biological process	negative regulation of protein tyrosine kinase activity
GO_0043409	Biological process	negative regulation of MAPK cascade
GO_0032682	Biological process	negative regulation of chemokine production
GO_0032689	Biological process	negative regulation of type II interferon production
GO_1900181	Biological process	negative regulation of protein localization to nucleus
GO_0032714	Biological process	negative regulation of interleukin-5 production
GO_0002669	Biological process	positive regulation of T cell anergy
GO_0032720	Biological process	negative regulation of tumor necrosis factor production
GO_0045591	Biological process	positive regulation of regulatory T cell differentiation
GO_0043124	Biological process	negative regulation of canonical NF-kappaB signal transduction
GO_0002774	Biological process	Fc receptor mediated inhibitory signaling pathway
GO_0005886	Cellular component	plasma membrane
GO_0009898	Cellular component	cytoplasmic side of plasma membrane
GO_0070062	Cellular component	extracellular exosome
GO_0009986	Cellular component	cell surface
GO_0019903	Molecular function	protein phosphatase binding
GO_0032396	Molecular function	inhibitory MHC class I receptor activity
GO_0030547	Molecular function	signaling receptor inhibitor activity
GO_0001968	Molecular function	fibronectin binding
GO_0034185	Molecular function	apolipoprotein binding
GO_0005515	Molecular function	protein binding
GO_0030293	Molecular function	transmembrane receptor protein tyrosine kinase inhibitor activity

IV. Literature review

[source]

Gene name	LILRB4
Protein name	Leukocyte immunoglobulin-like receptor subfamily B member 4 (B4) (CD85 antigen-like family member K) (Immunoglobulin-like transcript 3) (ILT-3) (Leukocyte immunoglobulin-like receptor 5) (LIR-5) (Monocyte inhibitory receptor HM18) (CD antigen CD85k) Leukocyte immunoglobulin-like receptor subfamily B member 4 Leukocyte immunoglobulin like receptor B4
Synonyms	LIR5 ILT3
Description	FUNCTION: Inhibitory receptor involved in the down-regulation of the immune response and the development of immune tolerance . Receptor for FN1 . Receptor for apolipoprotein APOE . Receptor for ALCAM/CD166 . Inhibits receptor-mediated phosphorylation of cellular proteins and mobilization of intracellular calcium ions . Inhibits FCGR1A/CD64-mediated monocyte activation by inducing phosphatase-mediated down-regulation of the phosphorylation of multiple proteins including LCK, SYK, LAT and ERK, leading to a reduction in TNF production . This inhibition of monocyte activation occurs at least in part via binding to FN1 . Inhibits T cell proliferation, inducing anergy, suppressing the differentiation of IFNG-producing CD8+ cytoxic T cells and enhancing the generation of CD8+ T suppressor cells . Induces up-regulation of CD86 on dendritic cells . Interferes with TNFRSF5-signaling and NF-kappa-B up-regulation . .
Accessions	ENST00000621149.4 ENST00000621368.4 A0A0G2JP84 A0A087X0F8 ENST00000430952.6 ENST00000611165.4 ENST00000617426.4 ENST00000391733.7 ENST00000613090.4 A0A0G2JQ20 ENST00000621985.4 A0A0A0MS20 A0A0G2JMH7 ENST00000621693.4 [Q8NHJ6-2] A0A0G2JPI0 A0A0G2JPX5 ENST00000612454.4 [Q8NHJ6-1] A0A0G2JM38 A0A0G2JNE9 A0A0G2JPA9 ENST00000616806.1 Q8NHJ6 A0A0G2JQ10 A0A8Q3SHR1 ENST00000618034.1 ENST00000620735.4 ENST00000617098.4 ENST00000615614.4 ENST00000622693.1 ENST00000614214.4 ENST00000621555.4 A0A0G2JM57 C9JST2 A0A0A0MQW7 ENST00000391734.7 ENST00000619525.1 A0A0G2JPV4 A8MUE1 ENST00000616137.4 ENST00000619910.4 ENST00000391736.5 ENST00000614340.4 A0A0G2JPC7 A0A0G2JML1 ENST00000695418.1 A0A0G2JPU4 A0A0G2JNL1 ENST00000618480.4 ENST00000614699.4 [Q8NHJ6-3] ENST00000494796.5 A0A0A0MSZ8 A0A0G2JM84 ENST00000434286.1 A0A0G2JNA7 A0A0G2JP25 A0A0G2JM43 ENST00000613131.1 ENST00000270452.6

LILRB4 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

IV. Literature review