LETMD1 | OmnibusX

I. Expression across cell types

Name	Number of supported studies	Average coverage
regulatory T cell	9 studies	18% ± 3%	Explore
CD4-positive, alpha-beta T cell	8 studies	21% ± 5%	Explore
naive thymus-derived CD4-positive, alpha-beta T cell	8 studies	22% ± 4%	Explore
naive thymus-derived CD8-positive, alpha-beta T cell	7 studies	20% ± 3%	Explore
fibroblast	7 studies	20% ± 4%	Explore
epithelial cell	7 studies	32% ± 16%	Explore
endothelial cell	5 studies	22% ± 6%	Explore
pericyte	4 studies	19% ± 3%	Explore
abnormal cell	4 studies	23% ± 6%	Explore
astrocyte	4 studies	29% ± 8%	Explore
adipocyte	4 studies	30% ± 14%	Explore
CD4-positive, alpha-beta memory T cell	4 studies	18% ± 1%	Explore
hematopoietic precursor cell	3 studies	26% ± 11%	Explore
classical monocyte	3 studies	20% ± 2%	Explore
non-classical monocyte	3 studies	23% ± 6%	Explore
smooth muscle cell	3 studies	20% ± 2%	Explore
type II pneumocyte	3 studies	18% ± 2%	Explore
ciliated cell	3 studies	22% ± 4%	Explore
B cell	3 studies	18% ± 0%	Explore
effector CD4-positive, alpha-beta T cell	3 studies	20% ± 3%	Explore
myofibroblast cell	3 studies	18% ± 2%	Explore
GABAergic neuron	3 studies	36% ± 8%	Explore
glutamatergic neuron	3 studies	44% ± 10%	Explore
oligodendrocyte precursor cell	3 studies	18% ± 1%	Explore
dendritic cell	3 studies	26% ± 8%	Explore
effector memory CD4-positive, alpha-beta T cell	3 studies	20% ± 5%	Explore
intestinal crypt stem cell	3 studies	22% ± 4%	Explore
basal cell	3 studies	31% ± 11%	Explore
transit amplifying cell	3 studies	24% ± 6%	Explore
hematopoietic stem cell	3 studies	25% ± 3%	Explore
plasmacytoid dendritic cell	3 studies	21% ± 3%	Explore
neuron	3 studies	27% ± 7%	Explore

II. Expression across tissues

Name	Number of supported studies	Average coverage
peripheral blood	5 studies	19% ± 4%	Explore
brain	4 studies	32% ± 10%	Explore
intestine	3 studies	22% ± 7%	Explore

Tissue	GTEx Coverage	GTEx Average TPM	GTEx Number of samples	TCGA Coverage	TCGA Average TPM	TCGA Number of samples
bladder	100%	3917.05	21 / 21	100%	28.96	504 / 504
esophagus	100%	2945.12	1445 / 1445	100%	21.80	183 / 183
lung	100%	3485.78	578 / 578	100%	26.80	1155 / 1155
pancreas	100%	3949.91	328 / 328	100%	28.42	178 / 178
prostate	100%	4382.25	245 / 245	100%	39.59	502 / 502
stomach	100%	3895.67	359 / 359	100%	28.06	286 / 286
thymus	100%	5301.81	653 / 653	100%	45.12	605 / 605
kidney	100%	4560.24	89 / 89	100%	36.03	900 / 901
brain	100%	3362.83	2639 / 2642	100%	31.13	705 / 705
intestine	100%	4099.04	966 / 966	100%	31.83	526 / 527
skin	100%	3839.63	1809 / 1809	100%	29.96	471 / 472
breast	100%	4639.85	459 / 459	100%	27.69	1115 / 1118
adrenal gland	100%	4625.74	258 / 258	100%	39.81	229 / 230
uterus	100%	4104.13	170 / 170	100%	25.52	457 / 459
ovary	100%	4964.41	180 / 180	100%	26.11	428 / 430
liver	100%	2812.00	226 / 226	100%	22.24	404 / 406
adipose	100%	4245.58	1204 / 1204	0%	0	0 / 0
eye	0%	0	0 / 0	100%	70.68	80 / 80
lymph node	0%	0	0 / 0	100%	32.75	29 / 29
spleen	100%	4572.95	241 / 241	0%	0	0 / 0
tonsil	0%	0	0 / 0	100%	22.39	45 / 45
ureter	0%	0	0 / 0	100%	17.49	1 / 1
blood vessel	100%	3023.01	1334 / 1335	0%	0	0 / 0
muscle	97%	1787.57	776 / 803	0%	0	0 / 0
heart	95%	1451.09	821 / 861	0%	0	0 / 0
peripheral blood	90%	2027.80	840 / 929	0%	0	0 / 0
abdomen	0%	0	0 / 0	0%	0	0 / 0
bone marrow	0%	0	0 / 0	0%	0	0 / 0
diaphragm	0%	0	0 / 0	0%	0	0 / 0
gingiva	0%	0	0 / 0	0%	0	0 / 0
nasal cavity	0%	0	0 / 0	0%	0	0 / 0
nasopharynx	0%	0	0 / 0	0%	0	0 / 0
nose	0%	0	0 / 0	0%	0	0 / 0
placenta	0%	0	0 / 0	0%	0	0 / 0
spinal column	0%	0	0 / 0	0%	0	0 / 0

III. Associated gene sets

GO_0030003	Biological process	intracellular monoatomic cation homeostasis
GO_0050764	Biological process	regulation of phagocytosis
GO_0007005	Biological process	mitochondrion organization
GO_0050727	Biological process	regulation of inflammatory response
GO_0120162	Biological process	positive regulation of cold-induced thermogenesis
GO_0005741	Cellular component	mitochondrial outer membrane
GO_0005730	Cellular component	nucleolus
GO_0005654	Cellular component	nucleoplasm
GO_0005743	Cellular component	mitochondrial inner membrane
GO_0005739	Cellular component	mitochondrion
GO_0043022	Molecular function	ribosome binding
GO_0005515	Molecular function	protein binding
GO_0060090	Molecular function	molecular adaptor activity

IV. Literature review

[source]

Gene name	LETMD1
Protein name	LETM1 domain containing 1 LETM1 domain-containing protein 1 (Cervical cancer 1 proto-oncogene protein p40) (Cervical cancer proto-oncogene 2 protein) (HCCR-1) (HCRR-2)
Synonyms
Description	FUNCTION: Plays an essential role for mitochondrial structure and function, as well as thermogenesis of brown adipocytes. In brown adipose tissue also localizes in the nucleus where it interacts with the chromatin remodeler SMARCA4 to regulate thermogenic genes expression, such as UCP1 (By similarity). May regulate phagocytosis and inflammatory responses to lipopolysaccharide in macrophages . Involved in tumorigenesis and may function as a negative regulator of the p53/TP53 . .
Accessions	ENST00000547256.1 ENST00000380135.7 F8VVQ3 H0YHF4 ENST00000549686.5 ENST00000547008.5 F8VR35 F8VQE7 F8W6J0 ENST00000262055.9 [Q6P1Q0-1] ENST00000548209.5 ENST00000550814.5 ENST00000550442.5 ENST00000547318.5 F8VTR1 H0YH93 ENST00000551261.5 Q6P1Q0 F8VZA2 ENST00000547555.5 ENST00000549340.5 ENST00000550755.5 ENST00000548251.5 ENST00000551477.5 ENST00000553043.1 H0YIV5 ENST00000551931.5 ENST00000552739.5 F8VS60 ENST00000548401.1 ENST00000418425.6 [Q6P1Q0-7] F8W1Z2 F8VXQ4 F8VUZ8 F8VPY5 F8WCD9 ENST00000550929.5 [Q6P1Q0-2] F8VR33 ENST00000547660.5 F8W1U1 F8VP71 F8W0R0 ENST00000550100.5 [Q6P1Q0-3]

LETMD1 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

IV. Literature review