LARP1 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0045948Biological processpositive regulation of translational initiation
GO_0008283Biological processcell population proliferation
GO_0031929Biological processTOR signaling
GO_0072752Biological processcellular response to rapamycin
GO_0048255Biological processmRNA stabilization
GO_0006413Biological processtranslational initiation
GO_0010608Biological processpost-transcriptional regulation of gene expression
GO_0045070Biological processpositive regulation of viral genome replication
GO_0016239Biological processpositive regulation of macroautophagy
GO_0045947Biological processnegative regulation of translational initiation
GO_0045727Biological processpositive regulation of translation
GO_1990928Biological processresponse to amino acid starvation
GO_0017148Biological processnegative regulation of translation
GO_0038202Biological processTORC1 signaling
GO_0016020Cellular componentmembrane
GO_0005829Cellular componentcytosol
GO_0031931Cellular componentTORC1 complex
GO_0005737Cellular componentcytoplasm
GO_0010494Cellular componentcytoplasmic stress granule
GO_0000339Molecular functionRNA cap binding
GO_0000340Molecular functionRNA 7-methylguanosine cap binding
GO_0031369Molecular functiontranslation initiation factor binding
GO_0048027Molecular functionmRNA 5'-UTR binding
GO_0008494Molecular functiontranslation activator activity
GO_0045296Molecular functioncadherin binding
GO_0043024Molecular functionribosomal small subunit binding
GO_0008190Molecular functioneukaryotic initiation factor 4E binding
GO_0003723Molecular functionRNA binding
GO_0003730Molecular functionmRNA 3'-UTR binding
GO_0005515Molecular functionprotein binding

IV. Literature review

[source]
Gene nameLARP1
Protein nameLa-related protein 1
La ribonucleoprotein 1, translational regulator
La ribonucleoprotein 1, translational regulator (La ribonucleoprotein domain family, member 1, isoform CRA_a)
La-related protein 1 (La ribonucleoprotein domain family member 1)
SynonymshCG_36852
KIAA0731
LARP
DescriptionFUNCTION: RNA-binding protein that regulates the translation of specific target mRNA species downstream of the mTORC1 complex, in function of growth signals and nutrient availability . Interacts on the one hand with the 3' poly-A tails that are present in all mRNA molecules, and on the other hand with the 7-methylguanosine cap structure of mRNAs containing a 5' terminal oligopyrimidine (5'TOP) motif, which is present in mRNAs encoding ribosomal proteins and several components of the translation machinery . The interaction with the 5' end of mRNAs containing a 5'TOP motif leads to translational repression by preventing the binding of EIF4G1 . When mTORC1 is activated, LARP1 is phosphorylated and dissociates from the 5' untranslated region (UTR) of mRNA . Does not prevent binding of EIF4G1 to mRNAs that lack a 5'TOP motif . Interacts with the free 40S ribosome subunit and with ribosomes, both monosomes and polysomes . Under normal nutrient availability, interacts primarily with the 3' untranslated region (UTR) of mRNAs encoding ribosomal proteins and increases protein synthesis . Associates with actively translating ribosomes and stimulates translation of mRNAs containing a 5'TOP motif, thereby regulating protein synthesis, and as a consequence, cell growth and proliferation . Stabilizes mRNAs species with a 5'TOP motif, which is required to prevent apoptosis . .; FUNCTION: (Microbial infection) Positively regulates the replication of dengue virus (DENV). .

AccessionsE5RHK4
H0YBW1
ENST00000518297
H0YAX9
ENST00000685946.1
ENST00000336314.9 [Q6PKG0-3]
ENST00000518677.1
Q6PKG0
H0YBR8
ENST00000522272.1
A0A8I5KSP1
H0YBM7
H0YC33
A0A0B4J210
ENST00000517616.5
ENST00000518742.1
ENST00000519931.5
ENST00000521577.1
H0YC73
H0YAN4
ENST00000518194.1
ENST00000524248.5
ENST00000518297.6 [Q6PKG0-1]
H0YBJ5
ENST00000690816.1
ENST00000687700.1
ENST00000518892.1
A0A8I5KWU3
ENST00000523163.5
E5RH50