Name | Number of supported studies | Average coverage | |
---|---|---|---|
endothelial cell | 14 studies | 32% ± 11% | |
macrophage | 14 studies | 25% ± 10% | |
fibroblast | 14 studies | 20% ± 5% | |
ciliated cell | 13 studies | 30% ± 10% | |
astrocyte | 12 studies | 33% ± 16% | |
oligodendrocyte precursor cell | 12 studies | 27% ± 11% | |
glutamatergic neuron | 11 studies | 44% ± 22% | |
oligodendrocyte | 11 studies | 29% ± 9% | |
neuron | 9 studies | 36% ± 15% | |
GABAergic neuron | 9 studies | 46% ± 22% | |
microglial cell | 9 studies | 25% ± 8% | |
epithelial cell | 9 studies | 40% ± 16% | |
adipocyte | 9 studies | 35% ± 7% | |
basal cell | 8 studies | 30% ± 10% | |
type I pneumocyte | 7 studies | 21% ± 5% | |
interneuron | 7 studies | 42% ± 25% | |
monocyte | 7 studies | 21% ± 3% | |
smooth muscle cell | 7 studies | 17% ± 2% | |
endothelial cell of lymphatic vessel | 6 studies | 22% ± 6% | |
retinal ganglion cell | 6 studies | 49% ± 25% | |
myeloid cell | 6 studies | 27% ± 6% | |
type II pneumocyte | 6 studies | 23% ± 9% | |
B cell | 5 studies | 20% ± 3% | |
non-classical monocyte | 5 studies | 26% ± 14% | |
abnormal cell | 5 studies | 31% ± 13% | |
plasma cell | 5 studies | 29% ± 12% | |
retina horizontal cell | 5 studies | 22% ± 5% | |
cardiac muscle cell | 5 studies | 26% ± 4% | |
pericyte | 5 studies | 21% ± 6% | |
goblet cell | 5 studies | 26% ± 7% | |
respiratory goblet cell | 4 studies | 28% ± 12% | |
secretory cell | 4 studies | 25% ± 9% | |
classical monocyte | 4 studies | 28% ± 12% | |
hematopoietic precursor cell | 4 studies | 30% ± 8% | |
granule cell | 4 studies | 22% ± 5% | |
club cell | 4 studies | 23% ± 4% | |
retinal pigment epithelial cell | 4 studies | 38% ± 13% | |
lymphocyte | 4 studies | 23% ± 6% | |
CD8-positive, alpha-beta T cell | 4 studies | 16% ± 1% | |
hepatocyte | 4 studies | 44% ± 14% | |
muscle cell | 4 studies | 21% ± 9% | |
natural killer cell | 3 studies | 17% ± 2% | |
ionocyte | 3 studies | 25% ± 5% | |
CD4-positive, alpha-beta T cell | 3 studies | 18% ± 3% | |
GABAergic interneuron | 3 studies | 36% ± 1% | |
progenitor cell | 3 studies | 20% ± 3% | |
myofibroblast cell | 3 studies | 22% ± 5% | |
retinal cone cell | 3 studies | 20% ± 1% | |
dendritic cell | 3 studies | 32% ± 15% | |
connective tissue cell | 3 studies | 19% ± 3% | |
ependymal cell | 3 studies | 38% ± 18% | |
mast cell | 3 studies | 24% ± 5% | |
megakaryocyte-erythroid progenitor cell | 3 studies | 28% ± 8% | |
enteroendocrine cell | 3 studies | 28% ± 5% | |
alveolar macrophage | 3 studies | 31% ± 10% | |
transit amplifying cell | 3 studies | 32% ± 14% | |
erythroblast | 3 studies | 41% ± 14% | |
epithelial cell of proximal tubule | 3 studies | 21% ± 6% | |
mucus secreting cell | 3 studies | 29% ± 8% |
Name | Number of supported studies | Average coverage | |
---|---|---|---|
brain | 17 studies | 35% ± 18% | |
lung | 8 studies | 23% ± 7% | |
heart | 4 studies | 19% ± 2% | |
liver | 4 studies | 37% ± 17% | |
peripheral blood | 3 studies | 28% ± 3% | |
eye | 3 studies | 26% ± 12% | |
bone marrow | 3 studies | 23% ± 6% | |
intestine | 3 studies | 22% ± 5% | |
adipose | 3 studies | 22% ± 1% |
Tissue | GTEx Coverage | GTEx Average TPM | GTEx Number of samples | TCGA Coverage | TCGA Average TPM | TCGA Number of samples |
---|---|---|---|---|---|---|
bladder | 100% | 10456.90 | 21 / 21 | 100% | 81.42 | 504 / 504 |
esophagus | 100% | 11137.98 | 1445 / 1445 | 100% | 115.84 | 183 / 183 |
intestine | 100% | 10916.29 | 966 / 966 | 100% | 101.36 | 527 / 527 |
breast | 100% | 10900.94 | 459 / 459 | 100% | 104.09 | 1117 / 1118 |
skin | 100% | 15007.13 | 1809 / 1809 | 100% | 118.94 | 471 / 472 |
ovary | 100% | 12395.26 | 180 / 180 | 100% | 95.83 | 429 / 430 |
stomach | 100% | 9940.56 | 359 / 359 | 100% | 101.87 | 285 / 286 |
prostate | 100% | 9693.11 | 245 / 245 | 100% | 87.72 | 500 / 502 |
thymus | 100% | 16034.10 | 653 / 653 | 100% | 104.77 | 602 / 605 |
pancreas | 100% | 13882.34 | 328 / 328 | 99% | 82.58 | 177 / 178 |
lung | 100% | 10416.34 | 578 / 578 | 99% | 88.88 | 1148 / 1155 |
uterus | 100% | 12136.44 | 170 / 170 | 99% | 85.56 | 456 / 459 |
kidney | 100% | 9015.16 | 89 / 89 | 99% | 84.42 | 894 / 901 |
adrenal gland | 100% | 14186.90 | 258 / 258 | 99% | 97.08 | 228 / 230 |
brain | 100% | 10360.17 | 2631 / 2642 | 99% | 88.52 | 700 / 705 |
liver | 100% | 5843.10 | 226 / 226 | 99% | 58.87 | 401 / 406 |
adipose | 100% | 11982.57 | 1204 / 1204 | 0% | 0 | 0 / 0 |
blood vessel | 100% | 10786.39 | 1335 / 1335 | 0% | 0 | 0 / 0 |
eye | 0% | 0 | 0 / 0 | 100% | 115.84 | 80 / 80 |
lymph node | 0% | 0 | 0 / 0 | 100% | 92.38 | 29 / 29 |
muscle | 100% | 13075.51 | 803 / 803 | 0% | 0 | 0 / 0 |
spleen | 100% | 10688.47 | 241 / 241 | 0% | 0 | 0 / 0 |
tonsil | 0% | 0 | 0 / 0 | 100% | 90.57 | 45 / 45 |
ureter | 0% | 0 | 0 / 0 | 100% | 29.63 | 1 / 1 |
heart | 97% | 8693.21 | 833 / 861 | 0% | 0 | 0 / 0 |
peripheral blood | 64% | 6108.68 | 592 / 929 | 0% | 0 | 0 / 0 |
abdomen | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
bone marrow | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
diaphragm | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
gingiva | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
nasal cavity | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
nasopharynx | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
nose | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
placenta | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
spinal column | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
GO_0045948 | Biological process | positive regulation of translational initiation |
GO_0008283 | Biological process | cell population proliferation |
GO_0031929 | Biological process | TOR signaling |
GO_0072752 | Biological process | cellular response to rapamycin |
GO_0048255 | Biological process | mRNA stabilization |
GO_0006413 | Biological process | translational initiation |
GO_0010608 | Biological process | post-transcriptional regulation of gene expression |
GO_0045070 | Biological process | positive regulation of viral genome replication |
GO_0016239 | Biological process | positive regulation of macroautophagy |
GO_0045947 | Biological process | negative regulation of translational initiation |
GO_0045727 | Biological process | positive regulation of translation |
GO_1990928 | Biological process | response to amino acid starvation |
GO_0017148 | Biological process | negative regulation of translation |
GO_0038202 | Biological process | TORC1 signaling |
GO_0016020 | Cellular component | membrane |
GO_0005829 | Cellular component | cytosol |
GO_0031931 | Cellular component | TORC1 complex |
GO_0005737 | Cellular component | cytoplasm |
GO_0010494 | Cellular component | cytoplasmic stress granule |
GO_0000339 | Molecular function | RNA cap binding |
GO_0000340 | Molecular function | RNA 7-methylguanosine cap binding |
GO_0031369 | Molecular function | translation initiation factor binding |
GO_0048027 | Molecular function | mRNA 5'-UTR binding |
GO_0008494 | Molecular function | translation activator activity |
GO_0045296 | Molecular function | cadherin binding |
GO_0043024 | Molecular function | ribosomal small subunit binding |
GO_0008190 | Molecular function | eukaryotic initiation factor 4E binding |
GO_0003723 | Molecular function | RNA binding |
GO_0003730 | Molecular function | mRNA 3'-UTR binding |
GO_0005515 | Molecular function | protein binding |
Gene name | LARP1 |
Protein name | La-related protein 1 La ribonucleoprotein 1, translational regulator La ribonucleoprotein 1, translational regulator (La ribonucleoprotein domain family, member 1, isoform CRA_a) La-related protein 1 (La ribonucleoprotein domain family member 1) |
Synonyms | hCG_36852 KIAA0731 LARP |
Description | FUNCTION: RNA-binding protein that regulates the translation of specific target mRNA species downstream of the mTORC1 complex, in function of growth signals and nutrient availability . Interacts on the one hand with the 3' poly-A tails that are present in all mRNA molecules, and on the other hand with the 7-methylguanosine cap structure of mRNAs containing a 5' terminal oligopyrimidine (5'TOP) motif, which is present in mRNAs encoding ribosomal proteins and several components of the translation machinery . The interaction with the 5' end of mRNAs containing a 5'TOP motif leads to translational repression by preventing the binding of EIF4G1 . When mTORC1 is activated, LARP1 is phosphorylated and dissociates from the 5' untranslated region (UTR) of mRNA . Does not prevent binding of EIF4G1 to mRNAs that lack a 5'TOP motif . Interacts with the free 40S ribosome subunit and with ribosomes, both monosomes and polysomes . Under normal nutrient availability, interacts primarily with the 3' untranslated region (UTR) of mRNAs encoding ribosomal proteins and increases protein synthesis . Associates with actively translating ribosomes and stimulates translation of mRNAs containing a 5'TOP motif, thereby regulating protein synthesis, and as a consequence, cell growth and proliferation . Stabilizes mRNAs species with a 5'TOP motif, which is required to prevent apoptosis . .; FUNCTION: (Microbial infection) Positively regulates the replication of dengue virus (DENV). . |
Accessions | E5RHK4 H0YBW1 ENST00000518297 H0YAX9 ENST00000685946.1 ENST00000336314.9 [Q6PKG0-3] ENST00000518677.1 Q6PKG0 H0YBR8 ENST00000522272.1 A0A8I5KSP1 H0YBM7 H0YC33 A0A0B4J210 ENST00000517616.5 ENST00000518742.1 ENST00000519931.5 ENST00000521577.1 H0YC73 H0YAN4 ENST00000518194.1 ENST00000524248.5 ENST00000518297.6 [Q6PKG0-1] H0YBJ5 ENST00000690816.1 ENST00000687700.1 ENST00000518892.1 A0A8I5KWU3 ENST00000523163.5 E5RH50 |