LAMP2 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0017038Biological processprotein import
GO_0046716Biological processmuscle cell cellular homeostasis
GO_0007042Biological processlysosomal lumen acidification
GO_0009267Biological processcellular response to starvation
GO_0006605Biological processprotein targeting
GO_0031647Biological processregulation of protein stability
GO_0061740Biological processprotein targeting to lysosome involved in chaperone-mediated autophagy
GO_0061684Biological processchaperone-mediated autophagy
GO_0050821Biological processprotein stabilization
GO_1905146Biological processlysosomal protein catabolic process
GO_0097352Biological processautophagosome maturation
GO_0005615Cellular componentextracellular space
GO_0031902Cellular componentlate endosome membrane
GO_0005886Cellular componentplasma membrane
GO_0016020Cellular componentmembrane
GO_0044754Cellular componentautolysosome
GO_0031088Cellular componentplatelet dense granule membrane
GO_0005764Cellular componentlysosome
GO_0000421Cellular componentautophagosome membrane
GO_0035577Cellular componentazurophil granule membrane
GO_0098857Cellular componentmembrane microdomain
GO_0070062Cellular componentextracellular exosome
GO_0005770Cellular componentlate endosome
GO_0101003Cellular componentficolin-1-rich granule membrane
GO_0030670Cellular componentphagocytic vesicle membrane
GO_0043231Cellular componentintracellular membrane-bounded organelle
GO_0043202Cellular componentlysosomal lumen
GO_0005765Cellular componentlysosomal membrane
GO_0019899Molecular functionenzyme binding
GO_0019904Molecular functionprotein domain specific binding
GO_0008200Molecular functionion channel inhibitor activity
GO_0005515Molecular functionprotein binding

IV. Literature review

[source]
Gene nameLAMP2
Protein nameLysosomal-associated membrane protein 2
Lysosomal associated membrane protein 2
Lysosome-associated membrane glycoprotein 2 (LAMP-2) (Lysosome-associated membrane protein 2) (CD107 antigen-like family member B) (LGP-96) (CD antigen CD107b)
Synonyms
DescriptionFUNCTION: Lysosomal membrane glycoprotein which plays an important role in lysosome biogenesis, lysosomal pH regulation and autophagy . Acts as an important regulator of lysosomal lumen pH regulation by acting as a direct inhibitor of the proton channel TMEM175, facilitating lysosomal acidification for optimal hydrolase activity . Plays an important role in chaperone-mediated autophagy, a process that mediates lysosomal degradation of proteins in response to various stresses and as part of the normal turnover of proteins with a long biological half-live . Functions by binding target proteins, such as GAPDH, NLRP3 and MLLT11, and targeting them for lysosomal degradation . In the chaperone-mediated autophagy, acts downstream of chaperones, such as HSPA8/HSC70, which recognize and bind substrate proteins and mediate their recruitment to lysosomes, where target proteins bind LAMP2 . Plays a role in lysosomal protein degradation in response to starvation (By similarity). Required for the fusion of autophagosomes with lysosomes during autophagy . Cells that lack LAMP2 express normal levels of VAMP8, but fail to accumulate STX17 on autophagosomes, which is the most likely explanation for the lack of fusion between autophagosomes and lysosomes . Required for normal degradation of the contents of autophagosomes . Required for efficient MHC class II-mediated presentation of exogenous antigens via its function in lysosomal protein degradation; antigenic peptides generated by proteases in the endosomal/lysosomal compartment are captured by nascent MHC II subunits . Is not required for efficient MHC class II-mediated presentation of endogenous antigens . .; FUNCTION: [Isoform LAMP-2C]: Modulates chaperone-mediated autophagy. Decreases presentation of endogenous antigens by MHCII. Does not play a role in the presentation of exogenous and membrane-derived antigens by MHCII. .; FUNCTION: (Microbial infection) Supports the FURIN-mediated cleavage of mumps virus fusion protein F by interacting with both FURIN and the unprocessed form but not the processed form of the viral protein F. .

AccessionsENST00000434600.6 [P13473-3]
P13473
ENST00000706600.1
H0YCG2
ENST00000200639.9 [P13473-1]
A0A9L9PXQ4
A0A1B1HY35
A0A1B1HY22
ENST00000371335.4 [P13473-2]
ENST00000486593.5