LAIR1 | OmnibusX

I. Expression across cell types

Name	Number of supported studies	Average coverage
macrophage	34 studies	35% ± 13%	Explore
classical monocyte	17 studies	23% ± 9%	Explore
plasmacytoid dendritic cell	16 studies	35% ± 12%	Explore
non-classical monocyte	16 studies	28% ± 8%	Explore
natural killer cell	15 studies	21% ± 4%	Explore
CD16-positive, CD56-dim natural killer cell, human	11 studies	25% ± 11%	Explore
mast cell	10 studies	26% ± 11%	Explore
monocyte	10 studies	30% ± 13%	Explore
myeloid cell	9 studies	34% ± 12%	Explore
alveolar macrophage	8 studies	37% ± 10%	Explore
conventional dendritic cell	7 studies	27% ± 7%	Explore
naive B cell	7 studies	19% ± 3%	Explore
mononuclear phagocyte	5 studies	30% ± 15%	Explore
CD16-negative, CD56-bright natural killer cell, human	5 studies	21% ± 3%	Explore
hematopoietic precursor cell	5 studies	27% ± 3%	Explore
hematopoietic stem cell	5 studies	21% ± 3%	Explore
pro-B cell	5 studies	31% ± 8%	Explore
B cell	5 studies	21% ± 6%	Explore
microglial cell	5 studies	33% ± 13%	Explore
mature NK T cell	4 studies	19% ± 4%	Explore
leukocyte	4 studies	18% ± 0%	Explore
dendritic cell	4 studies	26% ± 6%	Explore
common myeloid progenitor	3 studies	28% ± 11%	Explore
immature B cell	3 studies	39% ± 19%	Explore
tissue-resident macrophage	3 studies	37% ± 10%	Explore
intermediate monocyte	3 studies	30% ± 10%	Explore
granulocyte monocyte progenitor cell	3 studies	35% ± 8%	Explore
innate lymphoid cell	3 studies	20% ± 2%	Explore

II. Expression across tissues

Name	Number of supported studies	Average coverage
peripheral blood	5 studies	21% ± 5%	Explore

Tissue	GTEx Coverage	GTEx Average TPM	GTEx Number of samples	TCGA Coverage	TCGA Average TPM	TCGA Number of samples
lung	100%	4249.65	578 / 578	90%	13.39	1040 / 1155
breast	94%	1543.56	431 / 459	95%	12.66	1064 / 1118
intestine	93%	1089.30	897 / 966	65%	5.98	341 / 527
bladder	86%	886.81	18 / 21	62%	6.91	314 / 504
stomach	70%	509.05	251 / 359	77%	8.02	219 / 286
kidney	57%	566.36	51 / 89	88%	14.50	793 / 901
prostate	90%	874.19	220 / 245	55%	3.09	278 / 502
adrenal gland	98%	1578.04	253 / 258	43%	3.06	98 / 230
uterus	68%	416.48	115 / 170	69%	6.45	316 / 459
brain	44%	465.59	1163 / 2642	88%	14.71	619 / 705
esophagus	63%	481.39	917 / 1445	64%	5.17	118 / 183
thymus	58%	445.17	377 / 653	70%	15.84	421 / 605
ovary	41%	233.09	73 / 180	80%	8.66	346 / 430
pancreas	34%	244.03	110 / 328	86%	12.35	153 / 178
lymph node	0%	0	0 / 0	100%	35.66	29 / 29
spleen	100%	6319.80	241 / 241	0%	0	0 / 0
skin	19%	104.78	350 / 1809	81%	12.36	380 / 472
adipose	99%	2751.37	1192 / 1204	0%	0	0 / 0
tonsil	0%	0	0 / 0	84%	9.16	38 / 45
peripheral blood	81%	5289.25	757 / 929	0%	0	0 / 0
blood vessel	75%	1053.92	1004 / 1335	0%	0	0 / 0
liver	28%	194.71	63 / 226	45%	3.76	182 / 406
heart	38%	263.68	331 / 861	0%	0	0 / 0
eye	0%	0	0 / 0	26%	1.90	21 / 80
muscle	5%	24.48	41 / 803	0%	0	0 / 0
abdomen	0%	0	0 / 0	0%	0	0 / 0
bone marrow	0%	0	0 / 0	0%	0	0 / 0
diaphragm	0%	0	0 / 0	0%	0	0 / 0
gingiva	0%	0	0 / 0	0%	0	0 / 0
nasal cavity	0%	0	0 / 0	0%	0	0 / 0
nasopharynx	0%	0	0 / 0	0%	0	0 / 0
nose	0%	0	0 / 0	0%	0	0 / 0
placenta	0%	0	0 / 0	0%	0	0 / 0
spinal column	0%	0	0 / 0	0%	0	0 / 0
ureter	0%	0	0 / 0	0%	0	0 / 1

III. Associated gene sets

GO_0002250	Biological process	adaptive immune response
GO_0002764	Biological process	immune response-regulating signaling pathway
GO_0070821	Cellular component	tertiary granule membrane
GO_0035579	Cellular component	specific granule membrane
GO_0005886	Cellular component	plasma membrane
GO_0005515	Molecular function	protein binding

IV. Literature review

[source]

Gene name	LAIR1
Protein name	Leukocyte-associated immunoglobulin-like receptor 1 (LAIR-1) (hLAIR1) (CD antigen CD305) Leukocyte-associated immunoglobulin-like receptor 1 Leukocyte associated immunoglobulin like receptor 1
Synonyms	CD305
Description	FUNCTION: Functions as an inhibitory receptor that plays a constitutive negative regulatory role on cytolytic function of natural killer (NK) cells, B-cells and T-cells. Activation by Tyr phosphorylation results in recruitment and activation of the phosphatases PTPN6 and PTPN11. It also reduces the increase of intracellular calcium evoked by B-cell receptor ligation. May also play its inhibitory role independently of SH2-containing phosphatases. Modulates cytokine production in CD4+ T-cells, down-regulating IL2 and IFNG production while inducing secretion of transforming growth factor beta. Down-regulates also IgG and IgE production in B-cells as well as IL8, IL10 and TNF secretion. Inhibits proliferation and induces apoptosis in myeloid leukemia cell lines as well as prevents nuclear translocation of NF-kappa-B p65 subunit/RELA and phosphorylation of I-kappa-B alpha/CHUK in these cells. Inhibits the differentiation of peripheral blood precursors towards dendritic cells. .
Accessions	ENST00000621769.4 ENST00000617386.4 ENST00000622097.4 ENST00000617370.1 ENST00000438193.1 A0A0G2JQ50 ENST00000348231.8 [Q6GTX8-2] ENST00000614946.1 ENST00000474878.5 [Q6GTX8-3] ENST00000614880.1 ENST00000613311.4 ENST00000622064.1 ENST00000612909.4 ENST00000610549.4 ENST00000616612.4 ENST00000621291.4 ENST00000619817.4 ENST00000391741.6 Q6GTX8 A0A0G2JMI0 ENST00000611304.1 A0A0G2JP14 ENST00000436513.5 ENST00000617129.4 ENST00000618524.4 A0A0G2JP18 F2Z3B9 ENST00000618434.4 ENST00000618291.4 ENST00000616724.4 A0A0G2JMC3 ENST00000434277.6 W4VSQ5 ENST00000620726.1 ENST00000620357.4 ENST00000420483.5 ENST00000391743.7 A0A087X137 D3YTC8 ENST00000616413.4 C9IZB2 ENST00000619717.4 A0A0G2JM94 ENST00000614937.4 ENST00000391742.7 [Q6GTX8-1] A0A0G2JLV7 F8WC07 ENST00000313038.10 A8MZ84 A0A140T8W3 ENST00000418556.5 ENST00000617029.4 A0A0G2JNK8 ENST00000620077.4 A0A0G2JNU6

LAIR1 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

IV. Literature review