KPNA4 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0010467Biological processgene expression
GO_0006606Biological processprotein import into nucleus
GO_0006607Biological processNLS-bearing protein import into nucleus
GO_0014046Biological processdopamine secretion
GO_0042564Cellular componentNLS-dependent protein nuclear import complex
GO_0005654Cellular componentnucleoplasm
GO_0005829Cellular componentcytosol
GO_0005643Cellular componentnuclear pore
GO_0031965Cellular componentnuclear membrane
GO_0005634Cellular componentnucleus
GO_0008139Molecular functionnuclear localization sequence binding
GO_0005515Molecular functionprotein binding
GO_0061608Molecular functionnuclear import signal receptor activity

IV. Literature review

[source]
Gene nameKPNA4
Protein nameImportin subunit alpha
Karyopherin subunit alpha 4
KPNA4 protein
Importin subunit alpha-3 (Importin alpha Q1) (Qip1) (Karyopherin subunit alpha-4)
KPNA4 protein (Karyopherin alpha 4 (Importin alpha 3), isoform CRA_a)
SynonymsQIP1
hCG_17225
DescriptionFUNCTION: Functions in nuclear protein import as an adapter protein for nuclear receptor KPNB1. Binds specifically and directly to substrates containing either a simple or bipartite NLS motif. Docking of the importin/substrate complex to the nuclear pore complex (NPC) is mediated by KPNB1 through binding to nucleoporin FxFG repeats and the complex is subsequently translocated through the pore by an energy requiring, Ran-dependent mechanism. At the nucleoplasmic side of the NPC, Ran binds to importin-beta and the three components separate and importin-alpha and -beta are re-exported from the nucleus to the cytoplasm where GTP hydrolysis releases Ran from importin. The directionality of nuclear import is thought to be conferred by an asymmetric distribution of the GTP- and GDP-bound forms of Ran between the cytoplasm and nucleus. In vitro, mediates the nuclear import of human cytomegalovirus UL84 by recognizing a non-classical NLS. In vitro, mediates the nuclear import of human cytomegalovirus UL84 by recognizing a non-classical NLS.

FUNCTION: Functions in nuclear protein import. .

FUNCTION: Functions in nuclear protein import. .

FUNCTION: Functions in nuclear protein import. .

AccessionsENST00000678765.1
ENST00000676866.1
H7C4F6
ENST00000676958.1
ENST00000678630.1
A0A7I2V5X0
ENST00000676799.1
ENST00000483437.2
ENST00000469804.1
O00629
A0A7I2V340
A0A7I2V333
A0A7I2YQ95
Q96IJ5
Q96KW7
ENST00000334256.9