KPNA3 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0046718Biological processsymbiont entry into host cell
GO_0006606Biological processprotein import into nucleus
GO_0006607Biological processNLS-bearing protein import into nucleus
GO_0065003Biological processprotein-containing complex assembly
GO_0075732Biological processviral penetration into host nucleus
GO_0043657Cellular componenthost cell
GO_0042564Cellular componentNLS-dependent protein nuclear import complex
GO_0005654Cellular componentnucleoplasm
GO_0005829Cellular componentcytosol
GO_0005643Cellular componentnuclear pore
GO_0005634Cellular componentnucleus
GO_0008139Molecular functionnuclear localization sequence binding
GO_0005515Molecular functionprotein binding
GO_0061608Molecular functionnuclear import signal receptor activity

IV. Literature review

[source]
Gene nameKPNA3
Protein nameImportin subunit alpha-4 (Importin alpha Q2) (Qip2) (Karyopherin subunit alpha-3) (SRP1-gamma)
Karyopherin subunit alpha 3
SynonymsQIP2
DescriptionFUNCTION: Functions in nuclear protein import as an adapter protein for nuclear receptor KPNB1. Binds specifically and directly to substrates containing either a simple or bipartite NLS motif. Docking of the importin/substrate complex to the nuclear pore complex (NPC) is mediated by KPNB1 through binding to nucleoporin FxFG repeats and the complex is subsequently translocated through the pore by an energy requiring, Ran-dependent mechanism. At the nucleoplasmic side of the NPC, Ran binds to importin-beta and the three components separate and importin-alpha and -beta are re-exported from the nucleus to the cytoplasm where GTP hydrolysis releases Ran from importin. The directionality of nuclear import is thought to be conferred by an asymmetric distribution of the GTP- and GDP-bound forms of Ran between the cytoplasm and nucleus. In vitro, mediates the nuclear import of human cytomegalovirus UL84 by recognizing a non-classical NLS. Recognizes NLSs of influenza A virus nucleoprotein probably through ARM repeats 7-9.

AccessionsO00505
ENST00000261667.8
H0Y4S9
ENST00000436760.1