Name | Number of supported studies | Average coverage | |
---|---|---|---|
endothelial cell | 19 studies | 28% ± 8% | |
ciliated cell | 13 studies | 29% ± 9% | |
oligodendrocyte | 12 studies | 25% ± 10% | |
oligodendrocyte precursor cell | 11 studies | 27% ± 12% | |
natural killer cell | 11 studies | 17% ± 2% | |
glutamatergic neuron | 10 studies | 42% ± 25% | |
astrocyte | 10 studies | 32% ± 13% | |
type I pneumocyte | 9 studies | 29% ± 10% | |
microglial cell | 9 studies | 27% ± 9% | |
macrophage | 7 studies | 28% ± 6% | |
fibroblast | 7 studies | 19% ± 3% | |
GABAergic neuron | 7 studies | 43% ± 21% | |
interneuron | 6 studies | 38% ± 23% | |
epithelial cell | 6 studies | 36% ± 16% | |
retinal cone cell | 6 studies | 34% ± 9% | |
retinal rod cell | 6 studies | 41% ± 10% | |
endothelial cell of lymphatic vessel | 6 studies | 27% ± 5% | |
type II pneumocyte | 6 studies | 22% ± 6% | |
neuron | 5 studies | 36% ± 12% | |
myeloid cell | 5 studies | 22% ± 5% | |
dendritic cell | 5 studies | 27% ± 15% | |
CD16-positive, CD56-dim natural killer cell, human | 4 studies | 17% ± 2% | |
retina horizontal cell | 4 studies | 19% ± 3% | |
cardiac muscle cell | 4 studies | 24% ± 5% | |
Mueller cell | 4 studies | 18% ± 2% | |
gamma-delta T cell | 4 studies | 22% ± 11% | |
CD4-positive, alpha-beta T cell | 3 studies | 19% ± 2% | |
non-classical monocyte | 3 studies | 23% ± 10% | |
GABAergic interneuron | 3 studies | 22% ± 6% | |
retinal ganglion cell | 3 studies | 29% ± 6% | |
adipocyte | 3 studies | 17% ± 2% | |
lymphocyte | 3 studies | 20% ± 3% | |
CD8-positive, alpha-beta T cell | 3 studies | 19% ± 2% | |
regulatory T cell | 3 studies | 17% ± 1% | |
muscle cell | 3 studies | 23% ± 5% | |
B cell | 3 studies | 18% ± 2% | |
myofibroblast cell | 3 studies | 19% ± 3% | |
T cell | 3 studies | 20% ± 6% | |
alveolar macrophage | 3 studies | 25% ± 7% | |
monocyte | 3 studies | 24% ± 4% | |
pericyte | 3 studies | 17% ± 2% | |
basal cell | 3 studies | 34% ± 7% | |
transit amplifying cell | 3 studies | 30% ± 18% | |
CD16-negative, CD56-bright natural killer cell, human | 3 studies | 17% ± 1% | |
erythroblast | 3 studies | 25% ± 13% |
Tissue | GTEx Coverage | GTEx Average TPM | GTEx Number of samples | TCGA Coverage | TCGA Average TPM | TCGA Number of samples |
---|---|---|---|---|---|---|
esophagus | 100% | 3261.67 | 1445 / 1445 | 100% | 65.96 | 183 / 183 |
ovary | 100% | 1484.44 | 180 / 180 | 100% | 27.47 | 429 / 430 |
breast | 100% | 2391.54 | 459 / 459 | 100% | 44.80 | 1114 / 1118 |
intestine | 100% | 2901.92 | 966 / 966 | 100% | 51.79 | 525 / 527 |
brain | 99% | 2493.39 | 2625 / 2642 | 100% | 55.51 | 705 / 705 |
lung | 99% | 2628.74 | 574 / 578 | 100% | 44.91 | 1155 / 1155 |
thymus | 100% | 2245.60 | 651 / 653 | 99% | 34.26 | 601 / 605 |
stomach | 99% | 1858.18 | 355 / 359 | 99% | 54.27 | 284 / 286 |
bladder | 100% | 3259.81 | 21 / 21 | 98% | 40.45 | 494 / 504 |
uterus | 100% | 2234.21 | 170 / 170 | 97% | 37.83 | 447 / 459 |
prostate | 100% | 1955.04 | 244 / 245 | 97% | 21.93 | 487 / 502 |
liver | 99% | 1485.91 | 224 / 226 | 97% | 22.34 | 393 / 406 |
skin | 100% | 3730.46 | 1806 / 1809 | 95% | 40.69 | 450 / 472 |
adrenal gland | 99% | 2029.98 | 256 / 258 | 95% | 22.82 | 218 / 230 |
kidney | 98% | 1353.66 | 87 / 89 | 95% | 26.75 | 859 / 901 |
pancreas | 84% | 898.68 | 276 / 328 | 99% | 34.51 | 176 / 178 |
adipose | 100% | 2823.57 | 1204 / 1204 | 0% | 0 | 0 / 0 |
blood vessel | 100% | 2996.67 | 1335 / 1335 | 0% | 0 | 0 / 0 |
lymph node | 0% | 0 | 0 / 0 | 100% | 40.63 | 29 / 29 |
muscle | 100% | 12319.62 | 803 / 803 | 0% | 0 | 0 / 0 |
spleen | 100% | 1719.68 | 241 / 241 | 0% | 0 | 0 / 0 |
tonsil | 0% | 0 | 0 / 0 | 100% | 35.48 | 45 / 45 |
ureter | 0% | 0 | 0 / 0 | 100% | 8.60 | 1 / 1 |
heart | 95% | 2957.35 | 814 / 861 | 0% | 0 | 0 / 0 |
eye | 0% | 0 | 0 / 0 | 88% | 17.46 | 70 / 80 |
peripheral blood | 71% | 1665.02 | 659 / 929 | 0% | 0 | 0 / 0 |
abdomen | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
bone marrow | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
diaphragm | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
gingiva | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
nasal cavity | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
nasopharynx | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
nose | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
placenta | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
spinal column | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
GO_0046718 | Biological process | symbiont entry into host cell |
GO_0006606 | Biological process | protein import into nucleus |
GO_0006607 | Biological process | NLS-bearing protein import into nucleus |
GO_0065003 | Biological process | protein-containing complex assembly |
GO_0075732 | Biological process | viral penetration into host nucleus |
GO_0043657 | Cellular component | host cell |
GO_0042564 | Cellular component | NLS-dependent protein nuclear import complex |
GO_0005654 | Cellular component | nucleoplasm |
GO_0005829 | Cellular component | cytosol |
GO_0005643 | Cellular component | nuclear pore |
GO_0005634 | Cellular component | nucleus |
GO_0008139 | Molecular function | nuclear localization sequence binding |
GO_0005515 | Molecular function | protein binding |
GO_0061608 | Molecular function | nuclear import signal receptor activity |
Gene name | KPNA3 |
Protein name | Importin subunit alpha-4 (Importin alpha Q2) (Qip2) (Karyopherin subunit alpha-3) (SRP1-gamma) Karyopherin subunit alpha 3 |
Synonyms | QIP2 |
Description | FUNCTION: Functions in nuclear protein import as an adapter protein for nuclear receptor KPNB1. Binds specifically and directly to substrates containing either a simple or bipartite NLS motif. Docking of the importin/substrate complex to the nuclear pore complex (NPC) is mediated by KPNB1 through binding to nucleoporin FxFG repeats and the complex is subsequently translocated through the pore by an energy requiring, Ran-dependent mechanism. At the nucleoplasmic side of the NPC, Ran binds to importin-beta and the three components separate and importin-alpha and -beta are re-exported from the nucleus to the cytoplasm where GTP hydrolysis releases Ran from importin. The directionality of nuclear import is thought to be conferred by an asymmetric distribution of the GTP- and GDP-bound forms of Ran between the cytoplasm and nucleus. In vitro, mediates the nuclear import of human cytomegalovirus UL84 by recognizing a non-classical NLS. Recognizes NLSs of influenza A virus nucleoprotein probably through ARM repeats 7-9. |
Accessions | O00505 ENST00000261667.8 H0Y4S9 ENST00000436760.1 |