KITLG | OmnibusX

I. Expression across cell types

Name	Number of supported studies	Average coverage
endothelial cell	14 studies	27% ± 15%	Explore
fibroblast	8 studies	23% ± 4%	Explore
type II pneumocyte	5 studies	21% ± 4%	Explore
GABAergic neuron	5 studies	36% ± 15%	Explore
pericyte	5 studies	27% ± 13%	Explore
capillary endothelial cell	4 studies	20% ± 6%	Explore
glutamatergic neuron	4 studies	32% ± 12%	Explore
interneuron	4 studies	35% ± 13%	Explore
renal principal cell	4 studies	28% ± 5%	Explore
epithelial cell	3 studies	21% ± 4%	Explore
basal cell	3 studies	30% ± 13%	Explore
kidney distal convoluted tubule epithelial cell	3 studies	27% ± 7%	Explore

II. Expression across tissues

Name	Number of supported studies	Average coverage
brain	3 studies	37% ± 5%	Explore

Tissue	GTEx Coverage	GTEx Average TPM	GTEx Number of samples	TCGA Coverage	TCGA Average TPM	TCGA Number of samples
lung	100%	4990.87	578 / 578	98%	44.18	1129 / 1155
esophagus	99%	4719.92	1426 / 1445	96%	35.46	175 / 183
breast	98%	2313.76	451 / 459	92%	49.08	1024 / 1118
kidney	100%	3194.42	89 / 89	86%	35.86	774 / 901
stomach	100%	3178.02	359 / 359	85%	23.13	243 / 286
intestine	99%	4286.64	958 / 966	83%	17.56	440 / 527
prostate	99%	2073.89	242 / 245	78%	11.82	391 / 502
uterus	99%	2428.43	168 / 170	77%	17.77	352 / 459
bladder	100%	3824.48	21 / 21	61%	14.90	308 / 504
brain	52%	614.11	1385 / 2642	88%	17.57	623 / 705
thymus	95%	1367.15	620 / 653	43%	6.76	261 / 605
pancreas	43%	400.46	141 / 328	89%	21.55	158 / 178
skin	88%	3410.84	1585 / 1809	19%	2.33	91 / 472
adipose	99%	2388.11	1188 / 1204	0%	0	0 / 0
tonsil	0%	0	0 / 0	93%	32.37	42 / 45
blood vessel	83%	1089.82	1107 / 1335	0%	0	0 / 0
adrenal gland	50%	418.65	130 / 258	32%	4.76	74 / 230
ovary	61%	624.19	110 / 180	13%	1.39	56 / 430
heart	63%	619.60	541 / 861	0%	0	0 / 0
muscle	30%	231.59	242 / 803	0%	0	0 / 0
liver	1%	9.12	3 / 226	18%	2.31	75 / 406
spleen	9%	61.64	21 / 241	0%	0	0 / 0
eye	0%	0	0 / 0	4%	0.28	3 / 80
abdomen	0%	0	0 / 0	0%	0	0 / 0
bone marrow	0%	0	0 / 0	0%	0	0 / 0
diaphragm	0%	0	0 / 0	0%	0	0 / 0
gingiva	0%	0	0 / 0	0%	0	0 / 0
lymph node	0%	0	0 / 0	0%	0	0 / 29
nasal cavity	0%	0	0 / 0	0%	0	0 / 0
nasopharynx	0%	0	0 / 0	0%	0	0 / 0
nose	0%	0	0 / 0	0%	0	0 / 0
peripheral blood	0%	0	0 / 929	0%	0	0 / 0
placenta	0%	0	0 / 0	0%	0	0 / 0
spinal column	0%	0	0 / 0	0%	0	0 / 0
ureter	0%	0	0 / 0	0%	0	0 / 1

III. Associated gene sets

GO_0097324	Biological process	melanocyte migration
GO_0042102	Biological process	positive regulation of T cell proliferation
GO_0002244	Biological process	hematopoietic progenitor cell differentiation
GO_0007265	Biological process	Ras protein signal transduction
GO_0033026	Biological process	negative regulation of mast cell apoptotic process
GO_0045636	Biological process	positive regulation of melanocyte differentiation
GO_0001755	Biological process	neural crest cell migration
GO_0097531	Biological process	mast cell migration
GO_0042098	Biological process	T cell proliferation
GO_1902035	Biological process	positive regulation of hematopoietic stem cell proliferation
GO_0001541	Biological process	ovarian follicle development
GO_0033024	Biological process	mast cell apoptotic process
GO_0014070	Biological process	response to organic cyclic compound
GO_0007155	Biological process	cell adhesion
GO_0002763	Biological process	positive regulation of myeloid leukocyte differentiation
GO_1901534	Biological process	positive regulation of hematopoietic progenitor cell differentiation
GO_0050731	Biological process	positive regulation of peptidyl-tyrosine phosphorylation
GO_0097192	Biological process	extrinsic apoptotic signaling pathway in absence of ligand
GO_0002573	Biological process	myeloid leukocyte differentiation
GO_0070662	Biological process	mast cell proliferation
GO_0002687	Biological process	positive regulation of leukocyte migration
GO_0046579	Biological process	positive regulation of Ras protein signal transduction
GO_0008584	Biological process	male gonad development
GO_0008284	Biological process	positive regulation of cell population proliferation
GO_0035234	Biological process	ectopic germ cell programmed cell death
GO_0070668	Biological process	positive regulation of mast cell proliferation
GO_0035162	Biological process	embryonic hemopoiesis
GO_0005615	Cellular component	extracellular space
GO_0005856	Cellular component	cytoskeleton
GO_0005576	Cellular component	extracellular region
GO_0005886	Cellular component	plasma membrane
GO_0030175	Cellular component	filopodium
GO_0005737	Cellular component	cytoplasm
GO_0030027	Cellular component	lamellipodium
GO_0008083	Molecular function	growth factor activity
GO_0005173	Molecular function	stem cell factor receptor binding
GO_0005515	Molecular function	protein binding
GO_0005125	Molecular function	cytokine activity

IV. Literature review

[source]

Gene name	KITLG
Protein name	Kit ligand (Mast cell growth factor) (MGF) (Stem cell factor) (SCF) (c-Kit ligand) [Cleaved into: Soluble KIT ligand (sKITLG)] KIT ligand
Synonyms	SCF MGF
Description	FUNCTION: Ligand for the receptor-type protein-tyrosine kinase KIT. Plays an essential role in the regulation of cell survival and proliferation, hematopoiesis, stem cell maintenance, gametogenesis, mast cell development, migration and function, and in melanogenesis. KITLG/SCF binding can activate several signaling pathways. Promotes phosphorylation of PIK3R1, the regulatory subunit of phosphatidylinositol 3-kinase, and subsequent activation of the kinase AKT1. KITLG/SCF and KIT also transmit signals via GRB2 and activation of RAS, RAF1 and the MAP kinases MAPK1/ERK2 and/or MAPK3/ERK1. KITLG/SCF and KIT promote activation of STAT family members STAT1, STAT3 and STAT5. KITLG/SCF and KIT promote activation of PLCG1, leading to the production of the cellular signaling molecules diacylglycerol and inositol 1,4,5-trisphosphate. KITLG/SCF acts synergistically with other cytokines, probably interleukins.
Accessions	P21583 ENST00000347404.10 [P21583-2] ENST00000646633.1 S4R384 A0A2R8Y515 ENST00000357116.4 ENST00000552044.1 S4R442 ENST00000644744.1 [P21583-1]

KITLG report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

IV. Literature review