KAT8 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_1903108Biological processregulation of mitochondrial transcription
GO_0006357Biological processregulation of transcription by RNA polymerase II
GO_0050684Biological processregulation of mRNA processing
GO_0032480Biological processnegative regulation of type I interferon production
GO_0035166Biological processpost-embryonic hemopoiesis
GO_0060261Biological processpositive regulation of transcription initiation by RNA polymerase II
GO_0022008Biological processneurogenesis
GO_0010506Biological processregulation of autophagy
GO_0045893Biological processpositive regulation of DNA-templated transcription
GO_0030099Biological processmyeloid cell differentiation
GO_0010719Biological processnegative regulation of epithelial to mesenchymal transition
GO_1902726Biological processpositive regulation of skeletal muscle satellite cell differentiation
GO_0048477Biological processoogenesis
GO_0045892Biological processnegative regulation of DNA-templated transcription
GO_0045815Biological processtranscription initiation-coupled chromatin remodeling
GO_0044545Cellular componentNSL complex
GO_0071339Cellular componentMLL1 complex
GO_0005739Cellular componentmitochondrion
GO_0000776Cellular componentkinetochore
GO_0005654Cellular componentnucleoplasm
GO_0035267Cellular componentNuA4 histone acetyltransferase complex
GO_0016363Cellular componentnuclear matrix
GO_0072487Cellular componentMSL complex
GO_0005694Cellular componentchromosome
GO_0000785Cellular componentchromatin
GO_0000123Cellular componenthistone acetyltransferase complex
GO_0005634Cellular componentnucleus
GO_0019899Molecular functionenzyme binding
GO_0061733Molecular functionpeptide-lysine-N-acetyltransferase activity
GO_0003682Molecular functionchromatin binding
GO_0046972Molecular functionhistone H4K16 acetyltransferase activity
GO_0003712Molecular functiontranscription coregulator activity
GO_0061629Molecular functionRNA polymerase II-specific DNA-binding transcription factor binding
GO_0043996Molecular functionhistone H4K8 acetyltransferase activity
GO_0010485Molecular functionhistone H4 acetyltransferase activity
GO_0043995Molecular functionhistone H4K5 acetyltransferase activity
GO_0046872Molecular functionmetal ion binding
GO_0061920Molecular functionprotein propionyltransferase activity
GO_0003713Molecular functiontranscription coactivator activity
GO_0005515Molecular functionprotein binding

IV. Literature review

[source]
Gene nameKAT8
Protein nameHistone acetyltransferase KAT8 (EC 2.3.1.48) (Lysine acetyltransferase 8) (MOZ, YBF2/SAS3, SAS2 and TIP60 protein 1) (MYST-1) (hMOF)
Histone acetyltransferase (EC 2.3.1.48)
Lysine acetyltransferase 8
SynonymsMOF
MYST1
PP7073
DescriptionFUNCTION: Histone acetyltransferase which may be involved in transcriptional activation . May influence the function of ATM . As part of the MSL complex it is involved in acetylation of nucleosomal histone H4 producing specifically H4K16ac . As part of the NSL complex it may be involved in acetylation of nucleosomal histone H4 on several lysine residues . That activity is less specific than the one of the MSL complex . Can also acetylate TP53/p53 at 'Lys-120'. .

AccessionsENST00000537402.1
ENST00000219797.9 [Q9H7Z6-1]
A0A494C0I2
ENST00000448516.6 [Q9H7Z6-2]
Q9H7Z6
ENST00000543774.6 [Q9H7Z6-1]
H3BMX5
ENST00000652764.1