ITPA | OmnibusX

I. Expression across cell types

Name	Number of supported studies	Average coverage
natural killer cell	12 studies	19% ± 4%	Explore
CD8-positive, alpha-beta T cell	11 studies	20% ± 5%	Explore
CD16-positive, CD56-dim natural killer cell, human	8 studies	19% ± 3%	Explore
regulatory T cell	8 studies	20% ± 4%	Explore
CD16-negative, CD56-bright natural killer cell, human	7 studies	19% ± 4%	Explore
epithelial cell	7 studies	37% ± 18%	Explore
plasmacytoid dendritic cell	6 studies	24% ± 8%	Explore
classical monocyte	5 studies	24% ± 8%	Explore
conventional dendritic cell	5 studies	31% ± 15%	Explore
ciliated cell	5 studies	31% ± 7%	Explore
non-classical monocyte	4 studies	29% ± 9%	Explore
B cell	4 studies	21% ± 5%	Explore
endothelial cell	4 studies	24% ± 13%	Explore
fibroblast	4 studies	24% ± 8%	Explore
abnormal cell	4 studies	27% ± 5%	Explore
effector CD8-positive, alpha-beta T cell	4 studies	20% ± 3%	Explore
goblet cell	4 studies	21% ± 6%	Explore
basal cell	4 studies	29% ± 11%	Explore
CD4-positive, alpha-beta T cell	3 studies	21% ± 4%	Explore
exhausted T cell	3 studies	25% ± 8%	Explore
hematopoietic precursor cell	3 studies	32% ± 9%	Explore
mature NK T cell	3 studies	18% ± 3%	Explore
naive thymus-derived CD8-positive, alpha-beta T cell	3 studies	21% ± 4%	Explore
smooth muscle cell	3 studies	18% ± 3%	Explore
myofibroblast cell	3 studies	17% ± 1%	Explore
myeloid cell	3 studies	22% ± 7%	Explore
effector CD4-positive, alpha-beta T cell	3 studies	19% ± 3%	Explore
macrophage	3 studies	28% ± 5%	Explore
glutamatergic neuron	3 studies	25% ± 7%	Explore
oligodendrocyte precursor cell	3 studies	16% ± 0%	Explore
dendritic cell	3 studies	40% ± 10%	Explore
intestinal crypt stem cell	3 studies	23% ± 3%	Explore
CD4-positive, alpha-beta memory T cell	3 studies	20% ± 4%	Explore

II. Expression across tissues

Name	Number of supported studies	Average coverage
lung	5 studies	22% ± 4%	Explore
peripheral blood	4 studies	24% ± 8%	Explore
brain	3 studies	21% ± 5%	Explore
intestine	3 studies	23% ± 8%	Explore
liver	3 studies	29% ± 6%	Explore

Tissue	GTEx Coverage	GTEx Average TPM	GTEx Number of samples	TCGA Coverage	TCGA Average TPM	TCGA Number of samples
esophagus	100%	1642.27	1445 / 1445	100%	61.71	183 / 183
skin	100%	2206.73	1809 / 1809	100%	107.78	472 / 472
stomach	100%	1411.45	359 / 359	100%	80.45	286 / 286
uterus	100%	1509.92	170 / 170	100%	112.17	459 / 459
thymus	100%	2678.47	653 / 653	100%	104.05	604 / 605
ovary	100%	1444.04	180 / 180	100%	97.14	429 / 430
lung	100%	1512.22	577 / 578	100%	80.44	1153 / 1155
intestine	100%	1481.41	966 / 966	100%	94.22	525 / 527
bladder	100%	1621.43	21 / 21	100%	115.01	502 / 504
kidney	100%	2054.30	89 / 89	100%	70.43	897 / 901
prostate	100%	1747.68	245 / 245	99%	74.44	499 / 502
brain	99%	1135.76	2626 / 2642	100%	80.75	705 / 705
breast	100%	1732.75	459 / 459	99%	81.73	1110 / 1118
liver	100%	1199.30	226 / 226	99%	66.27	403 / 406
pancreas	100%	1050.80	327 / 328	99%	85.42	177 / 178
adrenal gland	100%	2325.82	258 / 258	99%	54.67	228 / 230
adipose	100%	1645.86	1204 / 1204	0%	0	0 / 0
eye	0%	0	0 / 0	100%	100.60	80 / 80
lymph node	0%	0	0 / 0	100%	152.98	29 / 29
spleen	100%	2160.71	241 / 241	0%	0	0 / 0
tonsil	0%	0	0 / 0	100%	84.19	45 / 45
ureter	0%	0	0 / 0	100%	112.93	1 / 1
blood vessel	100%	1387.44	1332 / 1335	0%	0	0 / 0
muscle	98%	867.01	785 / 803	0%	0	0 / 0
heart	97%	850.80	832 / 861	0%	0	0 / 0
peripheral blood	95%	1207.88	879 / 929	0%	0	0 / 0
abdomen	0%	0	0 / 0	0%	0	0 / 0
bone marrow	0%	0	0 / 0	0%	0	0 / 0
diaphragm	0%	0	0 / 0	0%	0	0 / 0
gingiva	0%	0	0 / 0	0%	0	0 / 0
nasal cavity	0%	0	0 / 0	0%	0	0 / 0
nasopharynx	0%	0	0 / 0	0%	0	0 / 0
nose	0%	0	0 / 0	0%	0	0 / 0
placenta	0%	0	0 / 0	0%	0	0 / 0
spinal column	0%	0	0 / 0	0%	0	0 / 0

III. Associated gene sets

GO_0006193	Biological process	ITP catabolic process
GO_0051276	Biological process	chromosome organization
GO_0009204	Biological process	deoxyribonucleoside triphosphate catabolic process
GO_0009143	Biological process	nucleoside triphosphate catabolic process
GO_0043231	Cellular component	intracellular membrane-bounded organelle
GO_0005654	Cellular component	nucleoplasm
GO_0005829	Cellular component	cytosol
GO_0005737	Cellular component	cytoplasm
GO_0035870	Molecular function	dITP diphosphatase activity
GO_0036222	Molecular function	XTP diphosphatase activity
GO_0042802	Molecular function	identical protein binding
GO_0047429	Molecular function	nucleoside triphosphate diphosphatase activity
GO_0046872	Molecular function	metal ion binding
GO_0000166	Molecular function	nucleotide binding
GO_0036220	Molecular function	ITP diphosphatase activity

IV. Literature review

[source]

Gene name	ITPA
Protein name	Epididymis secretory sperm binding protein (Inosine triphosphatase (Nucleoside triphosphate pyrophosphatase), isoform CRA_c) (Inosine triphosphatase isoform 1) ITPase Inosine triphosphate pyrophosphatase (ITPase) (Inosine triphosphatase) (EC 3.6.1.9) (Non-canonical purine NTP pyrophosphatase) (Non-standard purine NTP pyrophosphatase) (Nucleoside-triphosphate diphosphatase) (Nucleoside-triphosphate pyrophosphatase) (NTPase) (Putative oncogene protein hlc14-06-p) Inosine triphosphatase isoform 2
Synonyms	OK/SW-cl.9 hCG_39262 C20orf37 My049
Description	FUNCTION: Pyrophosphatase that hydrolyzes the non-canonical purine nucleotides inosine triphosphate (ITP), deoxyinosine triphosphate (dITP) as well as 2'-deoxy-N-6-hydroxylaminopurine triphosphate (dHAPTP) and xanthosine 5'-triphosphate (XTP) to their respective monophosphate derivatives. The enzyme does not distinguish between the deoxy- and ribose forms. Probably excludes non-canonical purines from RNA and DNA precursor pools, thus preventing their incorporation into RNA and DNA and avoiding chromosomal lesions. .
Accessions	ENST00000399838.3 [Q9BY32-3] ENST00000380113.8 [Q9BY32-1] A0A0S2Z423 A0A0S2Z3W7 Q9BY32 ENST00000455664.6 [Q9BY32-2] Q5NT82

ITPA report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

IV. Literature review