Name | Number of supported studies | Average coverage | |
---|---|---|---|
basal cell | 15 studies | 30% ± 10% | |
ciliated cell | 8 studies | 33% ± 16% | |
epithelial cell | 8 studies | 36% ± 15% | |
secretory cell | 4 studies | 28% ± 12% | |
goblet cell | 4 studies | 22% ± 1% | |
luminal hormone-sensing cell of mammary gland | 3 studies | 19% ± 3% | |
luminal cell of prostate epithelium | 3 studies | 27% ± 8% | |
enteroendocrine cell | 3 studies | 18% ± 2% | |
keratinocyte | 3 studies | 53% ± 12% |
Insufficient scRNA-seq data for expression of IRF6 at tissue level.
Tissue | GTEx Coverage | GTEx Average TPM | GTEx Number of samples | TCGA Coverage | TCGA Average TPM | TCGA Number of samples |
---|---|---|---|---|---|---|
thymus | 98% | 3003.62 | 642 / 653 | 98% | 71.12 | 590 / 605 |
prostate | 91% | 6273.23 | 222 / 245 | 100% | 109.34 | 500 / 502 |
pancreas | 87% | 1918.48 | 286 / 328 | 96% | 87.79 | 170 / 178 |
liver | 91% | 2300.04 | 206 / 226 | 80% | 55.73 | 325 / 406 |
stomach | 74% | 3428.29 | 265 / 359 | 93% | 55.35 | 265 / 286 |
breast | 59% | 2931.47 | 272 / 459 | 98% | 135.30 | 1099 / 1118 |
lung | 49% | 944.81 | 281 / 578 | 92% | 123.33 | 1065 / 1155 |
bladder | 43% | 2501.95 | 9 / 21 | 95% | 129.11 | 481 / 504 |
intestine | 40% | 1864.48 | 391 / 966 | 96% | 68.20 | 507 / 527 |
esophagus | 39% | 6220.61 | 561 / 1445 | 97% | 161.68 | 177 / 183 |
kidney | 96% | 2400.18 | 85 / 89 | 35% | 15.99 | 313 / 901 |
adrenal gland | 73% | 2046.66 | 188 / 258 | 43% | 23.13 | 99 / 230 |
tonsil | 0% | 0 | 0 / 0 | 100% | 250.76 | 45 / 45 |
ureter | 0% | 0 | 0 / 0 | 100% | 66.33 | 1 / 1 |
uterus | 6% | 236.20 | 11 / 170 | 85% | 202.93 | 392 / 459 |
ovary | 1% | 6.50 | 1 / 180 | 83% | 34.06 | 356 / 430 |
skin | 72% | 14900.76 | 1305 / 1809 | 5% | 2.98 | 25 / 472 |
heart | 72% | 1865.68 | 622 / 861 | 0% | 0 | 0 / 0 |
brain | 16% | 429.84 | 434 / 2642 | 1% | 0.24 | 6 / 705 |
blood vessel | 8% | 138.13 | 102 / 1335 | 0% | 0 | 0 / 0 |
adipose | 2% | 60.32 | 24 / 1204 | 0% | 0 | 0 / 0 |
eye | 0% | 0 | 0 / 0 | 1% | 0.33 | 1 / 80 |
spleen | 1% | 11.10 | 2 / 241 | 0% | 0 | 0 / 0 |
peripheral blood | 0% | 6.35 | 2 / 929 | 0% | 0 | 0 / 0 |
muscle | 0% | 2.72 | 1 / 803 | 0% | 0 | 0 / 0 |
abdomen | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
bone marrow | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
diaphragm | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
gingiva | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
lymph node | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 29 |
nasal cavity | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
nasopharynx | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
nose | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
placenta | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
spinal column | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
GO_0002376 | Biological process | immune system process |
GO_0030216 | Biological process | keratinocyte differentiation |
GO_0008285 | Biological process | negative regulation of cell population proliferation |
GO_1904888 | Biological process | cranial skeletal system development |
GO_0006357 | Biological process | regulation of transcription by RNA polymerase II |
GO_0060173 | Biological process | limb development |
GO_0072089 | Biological process | stem cell proliferation |
GO_0010839 | Biological process | negative regulation of keratinocyte proliferation |
GO_2000647 | Biological process | negative regulation of stem cell proliferation |
GO_0060021 | Biological process | roof of mouth development |
GO_0045893 | Biological process | positive regulation of DNA-templated transcription |
GO_0048468 | Biological process | cell development |
GO_0060644 | Biological process | mammary gland epithelial cell differentiation |
GO_0043616 | Biological process | keratinocyte proliferation |
GO_0045944 | Biological process | positive regulation of transcription by RNA polymerase II |
GO_0070062 | Cellular component | extracellular exosome |
GO_0005829 | Cellular component | cytosol |
GO_0005737 | Cellular component | cytoplasm |
GO_0000785 | Cellular component | chromatin |
GO_0005634 | Cellular component | nucleus |
GO_0003677 | Molecular function | DNA binding |
GO_0000978 | Molecular function | RNA polymerase II cis-regulatory region sequence-specific DNA binding |
GO_0001228 | Molecular function | DNA-binding transcription activator activity, RNA polymerase II-specific |
GO_0000981 | Molecular function | DNA-binding transcription factor activity, RNA polymerase II-specific |
GO_0043565 | Molecular function | sequence-specific DNA binding |
GO_1990837 | Molecular function | sequence-specific double-stranded DNA binding |
GO_0003700 | Molecular function | DNA-binding transcription factor activity |
GO_0005515 | Molecular function | protein binding |
Gene name | IRF6 |
Protein name | Interferon regulatory factor 6 (IRF-6) Interferon regulatory factor 6 |
Synonyms | |
Description | FUNCTION: Probable DNA-binding transcriptional activator. Key determinant of the keratinocyte proliferation-differentiation switch involved in appropriate epidermal development (By similarity). Plays a role in regulating mammary epithelial cell proliferation (By similarity). May regulate WDR65 transcription (By similarity). . |
Accessions | B1AJU4 A0A8Q3WL17 ENST00000542854.5 [O14896-2] A0A2R8YHF3 ENST00000367021.8 [O14896-1] G0Z349 ENST00000643798.1 ENST00000456314.1 ENST00000696134.1 O14896 |