Name | Number of supported studies | Average coverage | |
---|---|---|---|
endothelial cell | 16 studies | 27% ± 8% | |
smooth muscle cell | 14 studies | 21% ± 5% | |
fibroblast | 13 studies | 21% ± 4% | |
basal cell | 9 studies | 26% ± 12% | |
pericyte | 9 studies | 23% ± 5% | |
epithelial cell | 8 studies | 38% ± 20% | |
macrophage | 8 studies | 24% ± 5% | |
type I pneumocyte | 6 studies | 22% ± 6% | |
glutamatergic neuron | 6 studies | 43% ± 25% | |
endothelial cell of vascular tree | 6 studies | 23% ± 8% | |
GABAergic neuron | 6 studies | 39% ± 20% | |
type II pneumocyte | 5 studies | 25% ± 7% | |
conventional dendritic cell | 5 studies | 21% ± 7% | |
neuron | 5 studies | 28% ± 9% | |
myeloid cell | 5 studies | 23% ± 6% | |
dendritic cell | 5 studies | 26% ± 9% | |
oligodendrocyte | 5 studies | 26% ± 7% | |
classical monocyte | 4 studies | 22% ± 2% | |
non-classical monocyte | 4 studies | 18% ± 3% | |
hematopoietic precursor cell | 4 studies | 24% ± 4% | |
microglial cell | 4 studies | 26% ± 7% | |
club cell | 4 studies | 24% ± 5% | |
vein endothelial cell | 4 studies | 25% ± 9% | |
lymphocyte | 4 studies | 20% ± 5% | |
secretory cell | 4 studies | 19% ± 3% | |
naive B cell | 4 studies | 17% ± 2% | |
goblet cell | 4 studies | 29% ± 14% | |
alveolar macrophage | 4 studies | 22% ± 5% | |
astrocyte | 4 studies | 29% ± 6% | |
interneuron | 4 studies | 41% ± 22% | |
endothelial cell of lymphatic vessel | 3 studies | 24% ± 6% | |
ciliated cell | 3 studies | 33% ± 11% | |
retinal cone cell | 3 studies | 26% ± 4% | |
adipocyte | 3 studies | 22% ± 1% | |
luminal cell of prostate epithelium | 3 studies | 23% ± 7% | |
muscle cell | 3 studies | 27% ± 5% | |
oligodendrocyte precursor cell | 3 studies | 30% ± 8% | |
abnormal cell | 3 studies | 25% ± 11% | |
connective tissue cell | 3 studies | 18% ± 3% | |
megakaryocyte-erythroid progenitor cell | 3 studies | 29% ± 8% | |
monocyte | 3 studies | 18% ± 1% | |
intestinal crypt stem cell | 3 studies | 21% ± 4% | |
transit amplifying cell | 3 studies | 38% ± 19% | |
erythroblast | 3 studies | 30% ± 9% |
Tissue | GTEx Coverage | GTEx Average TPM | GTEx Number of samples | TCGA Coverage | TCGA Average TPM | TCGA Number of samples |
---|---|---|---|---|---|---|
esophagus | 100% | 8998.02 | 1445 / 1445 | 100% | 110.67 | 183 / 183 |
ovary | 100% | 7334.38 | 180 / 180 | 100% | 59.67 | 429 / 430 |
lung | 100% | 7990.19 | 576 / 578 | 100% | 91.21 | 1155 / 1155 |
breast | 100% | 6633.89 | 459 / 459 | 100% | 107.69 | 1113 / 1118 |
brain | 99% | 5575.38 | 2627 / 2642 | 100% | 97.03 | 705 / 705 |
stomach | 100% | 6028.96 | 359 / 359 | 99% | 95.61 | 284 / 286 |
intestine | 100% | 8443.53 | 966 / 966 | 99% | 96.42 | 522 / 527 |
thymus | 100% | 7811.33 | 653 / 653 | 99% | 92.23 | 599 / 605 |
prostate | 100% | 6081.68 | 244 / 245 | 99% | 72.66 | 497 / 502 |
uterus | 100% | 7544.29 | 170 / 170 | 98% | 66.56 | 451 / 459 |
pancreas | 99% | 4476.70 | 324 / 328 | 99% | 60.77 | 177 / 178 |
bladder | 100% | 11386.33 | 21 / 21 | 98% | 70.64 | 492 / 504 |
kidney | 100% | 5395.72 | 89 / 89 | 98% | 67.27 | 879 / 901 |
skin | 100% | 10069.68 | 1807 / 1809 | 96% | 88.99 | 452 / 472 |
adrenal gland | 100% | 6469.24 | 258 / 258 | 88% | 40.10 | 202 / 230 |
liver | 94% | 3255.15 | 213 / 226 | 90% | 37.34 | 364 / 406 |
adipose | 100% | 7674.50 | 1204 / 1204 | 0% | 0 | 0 / 0 |
blood vessel | 100% | 11381.53 | 1335 / 1335 | 0% | 0 | 0 / 0 |
lymph node | 0% | 0 | 0 / 0 | 100% | 58.52 | 29 / 29 |
muscle | 100% | 19334.86 | 803 / 803 | 0% | 0 | 0 / 0 |
spleen | 100% | 3812.85 | 241 / 241 | 0% | 0 | 0 / 0 |
tonsil | 0% | 0 | 0 / 0 | 100% | 66.92 | 45 / 45 |
ureter | 0% | 0 | 0 / 0 | 100% | 32.03 | 1 / 1 |
eye | 0% | 0 | 0 / 0 | 95% | 64.91 | 76 / 80 |
heart | 94% | 7089.86 | 808 / 861 | 0% | 0 | 0 / 0 |
peripheral blood | 39% | 2022.02 | 362 / 929 | 0% | 0 | 0 / 0 |
abdomen | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
bone marrow | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
diaphragm | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
gingiva | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
nasal cavity | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
nasopharynx | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
nose | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
placenta | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
spinal column | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
GO_0045736 | Biological process | negative regulation of cyclin-dependent protein serine/threonine kinase activity |
GO_0006606 | Biological process | protein import into nucleus |
GO_0045668 | Biological process | negative regulation of osteoblast differentiation |
GO_0045087 | Biological process | innate immune response |
GO_1900182 | Biological process | positive regulation of protein localization to nucleus |
GO_1901331 | Biological process | positive regulation of odontoblast differentiation |
GO_0005654 | Cellular component | nucleoplasm |
GO_0005829 | Cellular component | cytosol |
GO_0005643 | Cellular component | nuclear pore |
GO_0016020 | Cellular component | membrane |
GO_0005635 | Cellular component | nuclear envelope |
GO_0030695 | Molecular function | GTPase regulator activity |
GO_0046332 | Molecular function | SMAD binding |
GO_0005515 | Molecular function | protein binding |
GO_0031267 | Molecular function | small GTPase binding |
GO_0042393 | Molecular function | histone binding |
Gene name | IPO7 |
Protein name | Alternative protein IPO7 Importin-7 (Imp7) (Ran-binding protein 7) (RanBP7) Importin 7 |
Synonyms | RANBP7 |
Description | FUNCTION: Functions in nuclear protein import, either by acting as autonomous nuclear transport receptor or as an adapter-like protein in association with the importin-beta subunit KPNB1. Acting autonomously, is thought to serve itself as receptor for nuclear localization signals (NLS) and to promote translocation of import substrates through the nuclear pore complex (NPC) by an energy requiring, Ran-dependent mechanism. At the nucleoplasmic side of the NPC, Ran binds to importin, the importin/substrate complex dissociates and importin is re-exported from the nucleus to the cytoplasm where GTP hydrolysis releases Ran. The directionality of nuclear import is thought to be conferred by an asymmetric distribution of the GTP- and GDP-bound forms of Ran between the cytoplasm and nucleus. Mediates autonomously the nuclear import of ribosomal proteins RPL23A, RPS7 and RPL5 . In association with KPNB1 mediates the nuclear import of H1 histone and the Ran-binding site of IPO7 is not required but synergizes with that of KPNB1 in importin/substrate complex dissociation. Promotes odontoblast differentiation via promoting nuclear translocation of DLX3, KLF4, SMAD2, thereby facilitating the transcription of target genes that play a role in odontoblast differentiation (By similarity). Facilitates BMP4-induced translocation of SMAD1 to the nucleus and recruitment to the MSX1 gene promoter, thereby promotes the expression of the odontogenic regulator MSX1 in dental mesenchymal cells (By similarity). Also promotes odontoblast differentiation by facilitating the nuclear translocation of HDAC6 and subsequent repression of RUNX2 expression (By similarity). Inhibits osteoblast differentiation by inhibiting nuclear translocation of RUNX2 and therefore inhibition of RUNX2 target gene transcription (By similarity). In vitro, mediates nuclear import of H2A, H2B, H3 and H4 histones. .; FUNCTION: (Microbial infection) Mediates the nuclear import of HIV-1 reverse transcription complex (RTC) integrase. Binds and mediates the nuclear import of HIV-1 Rev. . |
Accessions | O95373 E9PLB2 E9PLJ0 L8E8A9 ENST00000379719.8 ENST00000533233.1 ENST00000527431.1 ENST00000630083.1 |