IL11 | OmnibusX

sc-RNAseq data

Insufficient scRNA-seq data for expression of IL11 at tissue level.

Tissue	GTEx Coverage	GTEx Average TPM	GTEx Number of samples	TCGA Coverage	TCGA Average TPM	TCGA Number of samples
intestine	80%	49.20	775 / 966	71%	7.10	375 / 527
stomach	72%	195.27	258 / 359	72%	6.68	207 / 286
bladder	62%	99.95	13 / 21	76%	7.06	384 / 504
esophagus	52%	32.30	746 / 1445	86%	5.97	157 / 183
lung	71%	78.78	411 / 578	65%	3.94	750 / 1155
skin	99%	166.90	1789 / 1809	31%	3.86	147 / 472
prostate	89%	200.30	218 / 245	40%	0.79	199 / 502
uterus	51%	25.66	86 / 170	77%	9.80	354 / 459
brain	91%	155.62	2393 / 2642	31%	1.04	217 / 705
pancreas	23%	8.43	74 / 328	81%	8.59	144 / 178
ureter	0%	0	0 / 0	100%	2.46	1 / 1
breast	46%	22.15	212 / 459	52%	1.27	585 / 1118
ovary	41%	23.44	73 / 180	55%	1.65	238 / 430
kidney	90%	261.54	80 / 89	6%	0.31	50 / 901
tonsil	0%	0	0 / 0	78%	3.66	35 / 45
adrenal gland	21%	7.61	55 / 258	24%	1.78	56 / 230
spleen	33%	10.69	79 / 241	0%	0	0 / 0
adipose	28%	22.23	341 / 1204	0%	0	0 / 0
thymus	14%	3.68	90 / 653	14%	0.62	87 / 605
liver	8%	4.14	18 / 226	9%	1.63	38 / 406
heart	17%	17.24	147 / 861	0%	0	0 / 0
blood vessel	11%	6.09	148 / 1335	0%	0	0 / 0
lymph node	0%	0	0 / 0	10%	0.22	3 / 29
peripheral blood	3%	0.70	25 / 929	0%	0	0 / 0
eye	0%	0	0 / 0	1%	0.02	1 / 80
muscle	1%	0.12	5 / 803	0%	0	0 / 0
abdomen	0%	0	0 / 0	0%	0	0 / 0
bone marrow	0%	0	0 / 0	0%	0	0 / 0
diaphragm	0%	0	0 / 0	0%	0	0 / 0
gingiva	0%	0	0 / 0	0%	0	0 / 0
nasal cavity	0%	0	0 / 0	0%	0	0 / 0
nasopharynx	0%	0	0 / 0	0%	0	0 / 0
nose	0%	0	0 / 0	0%	0	0 / 0
placenta	0%	0	0 / 0	0%	0	0 / 0
spinal column	0%	0	0 / 0	0%	0	0 / 0

GO_0046888	Biological process	negative regulation of hormone secretion
GO_2000352	Biological process	negative regulation of endothelial cell apoptotic process
GO_0008283	Biological process	cell population proliferation
GO_0033138	Biological process	positive regulation of peptidyl-serine phosphorylation
GO_0038154	Biological process	interleukin-11-mediated signaling pathway
GO_0043410	Biological process	positive regulation of MAPK cascade
GO_0050731	Biological process	positive regulation of peptidyl-tyrosine phosphorylation
GO_1903659	Biological process	regulation of complement-dependent cytotoxicity
GO_0008284	Biological process	positive regulation of cell population proliferation
GO_0030219	Biological process	megakaryocyte differentiation
GO_0030183	Biological process	B cell differentiation
GO_0045444	Biological process	fat cell differentiation
GO_0045944	Biological process	positive regulation of transcription by RNA polymerase II
GO_0005615	Cellular component	extracellular space
GO_0005576	Cellular component	extracellular region
GO_0005737	Cellular component	cytoplasm
GO_0008083	Molecular function	growth factor activity
GO_0005125	Molecular function	cytokine activity
GO_0005142	Molecular function	interleukin-11 receptor binding
GO_0005515	Molecular function	protein binding

Gene name	IL11
Protein name	Interleukin 11 (cDNA, FLJ96313, Homo sapiens interleukin 11 (IL11), mRNA) Interleukin-11 (IL-11) (Adipogenesis inhibitory factor) (AGIF) (Oprelvekin) Interleukin 11
Synonyms	hCG_37996
Description	FUNCTION: Cytokine that stimulates the proliferation of hematopoietic stem cells and megakaryocyte progenitor cells and induces megakaryocyte maturation resulting in increased platelet production . Also promotes the proliferation of hepatocytes in response to liver damage. Binding to its receptor formed by IL6ST and IL11RA activates a signaling cascade that promotes cell proliferation . Signaling leads to the activation of intracellular protein kinases and the phosphorylation of STAT3. The interaction with the membrane-bound IL11RA and IL6ST stimulates 'classic signaling', whereas the binding of IL11 and soluble IL11RA to IL6ST stimulates 'trans-signaling' . .
Accessions	ENST00000264563.7 [P20809-1] P20809 ENST00000587093.1 ENST00000590625.5 [P20809-2] K7ESD5 A8K3F7 ENST00000585513.1 [P20809-1]

IL11 report