IFI35 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0002281Biological processmacrophage activation involved in immune response
GO_0008285Biological processnegative regulation of cell population proliferation
GO_0050729Biological processpositive regulation of inflammatory response
GO_1901224Biological processpositive regulation of non-canonical NF-kappaB signal transduction
GO_0034145Biological processpositive regulation of toll-like receptor 4 signaling pathway
GO_0045089Biological processpositive regulation of innate immune response
GO_1901223Biological processnegative regulation of non-canonical NF-kappaB signal transduction
GO_0045087Biological processinnate immune response
GO_0005730Cellular componentnucleolus
GO_0005615Cellular componentextracellular space
GO_0005654Cellular componentnucleoplasm
GO_0005829Cellular componentcytosol
GO_0016020Cellular componentmembrane
GO_0005737Cellular componentcytoplasm
GO_0005634Cellular componentnucleus
GO_0042802Molecular functionidentical protein binding
GO_0005515Molecular functionprotein binding

IV. Literature review

[source]
Gene nameIFI35
Protein nameInterferon-induced 35 kDa protein (IFP 35) (Ifi-35)
SynonymsIFP35
DescriptionFUNCTION: Acts as a signaling pathway regulator involved in innate immune system response . In response to interferon IFN-alpha, associates in a complex with signaling pathway regulator NMI to regulate immune response; the complex formation prevents proteasome-mediated degradation of IFI35 and correlates with IFI35 dephosphorylation . In complex with NMI, inhibits virus-triggered type I interferon/IFN-beta production . In complex with NMI, negatively regulates nuclear factor NF-kappa-B signaling by inhibiting the nuclear translocation, activation and transcription of the NF-kappa-B subunit p65/RELA, resulting in the inhibition of endothelial cell proliferation, migration and re-endothelialization of injured arteries . Beside its role as an intracellular signaling pathway regulator, also functions extracellularly as damage-associated molecular patterns (DAMPs) to promote inflammation when actively released by macrophage to the extracellular space during cell injury and pathogen invasion . Macrophage-secreted IFI35 activates NF-kappa-B signaling in adjacent macrophages through Toll-like receptor 4/TLR4 activation, thereby inducing NF-kappa-B translocation from the cytoplasm into the nucleus which promotes the release of pro-inflammatory cytokines . .

AccessionsENST00000415816.7 [P80217-1]
P80217
ENST00000438323.2 [P80217-2]