HDAC6 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0060632Biological processregulation of microtubule-based movement
GO_0031333Biological processnegative regulation of protein-containing complex assembly
GO_0007026Biological processnegative regulation of microtubule depolymerization
GO_0061734Biological processparkin-mediated stimulation of mitophagy in response to mitochondrial depolarization
GO_0051354Biological processnegative regulation of oxidoreductase activity
GO_0045861Biological processnegative regulation of proteolysis
GO_0045598Biological processregulation of fat cell differentiation
GO_0070845Biological processpolyubiquitinated misfolded protein transport
GO_0006914Biological processautophagy
GO_0070301Biological processcellular response to hydrogen peroxide
GO_0006515Biological processprotein quality control for misfolded or incompletely synthesized proteins
GO_0060271Biological processcilium assembly
GO_0000209Biological processprotein polyubiquitination
GO_0048668Biological processcollateral sprouting
GO_2000273Biological processpositive regulation of signaling receptor activity
GO_0070201Biological processregulation of establishment of protein localization
GO_0071374Biological processcellular response to parathyroid hormone stimulus
GO_0035967Biological processcellular response to topologically incorrect protein
GO_1904056Biological processpositive regulation of cholangiocyte proliferation
GO_0010506Biological processregulation of autophagy
GO_0032418Biological processlysosome localization
GO_0060765Biological processregulation of androgen receptor signaling pathway
GO_0040029Biological processepigenetic regulation of gene expression
GO_0019896Biological processaxonal transport of mitochondrion
GO_0070848Biological processresponse to growth factor
GO_0051412Biological processresponse to corticosterone
GO_0048843Biological processnegative regulation of axon extension involved in axon guidance
GO_0045814Biological processnegative regulation of gene expression, epigenetic
GO_0032984Biological processprotein-containing complex disassembly
GO_0033138Biological processpositive regulation of peptidyl-serine phosphorylation
GO_0035902Biological processresponse to immobilization stress
GO_0090042Biological processtubulin deacetylation
GO_0006476Biological processprotein deacetylation
GO_0106048Biological processspermidine deacetylation
GO_0031648Biological processprotein destabilization
GO_0010727Biological processnegative regulation of hydrogen peroxide metabolic process
GO_0071548Biological processresponse to dexamethasone
GO_0034983Biological processpeptidyl-lysine deacetylation
GO_0050775Biological processpositive regulation of dendrite morphogenesis
GO_0090044Biological processpositive regulation of tubulin deacetylation
GO_0001975Biological processresponse to amphetamine
GO_0045892Biological processnegative regulation of DNA-templated transcription
GO_0010634Biological processpositive regulation of epithelial cell migration
GO_1905336Biological processnegative regulation of aggrephagy
GO_0034605Biological processcellular response to heat
GO_0061523Biological processcilium disassembly
GO_0006886Biological processintracellular protein transport
GO_0071218Biological processcellular response to misfolded protein
GO_0106047Biological processpolyamine deacetylation
GO_0043162Biological processubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway
GO_1903146Biological processregulation of autophagy of mitochondrion
GO_0051788Biological processresponse to misfolded protein
GO_0043242Biological processnegative regulation of protein-containing complex disassembly
GO_0007015Biological processactin filament organization
GO_0051968Biological processpositive regulation of synaptic transmission, glutamatergic
GO_0070842Biological processaggresome assembly
GO_1900409Biological processpositive regulation of cellular response to oxidative stress
GO_0016241Biological processregulation of macroautophagy
GO_1901984Biological processnegative regulation of protein acetylation
GO_0031647Biological processregulation of protein stability
GO_0043131Biological processerythrocyte enucleation
GO_0060997Biological processdendritic spine morphogenesis
GO_0016235Cellular componentaggresome
GO_0005634Cellular componentnucleus
GO_0005654Cellular componentnucleoplasm
GO_0030425Cellular componentdendrite
GO_0005874Cellular componentmicrotubule
GO_0043204Cellular componentperikaryon
GO_0005813Cellular componentcentrosome
GO_0031252Cellular componentcell leading edge
GO_0016234Cellular componentinclusion body
GO_0000118Cellular componenthistone deacetylase complex
GO_0005771Cellular componentmultivesicular body
GO_0005737Cellular componentcytoplasm
GO_0030424Cellular componentaxon
GO_0036064Cellular componentciliary basal body
GO_1904115Cellular componentaxon cytoplasm
GO_0005901Cellular componentcaveola
GO_0048471Cellular componentperinuclear region of cytoplasm
GO_0005829Cellular componentcytosol
GO_0005875Cellular componentmicrotubule associated complex
GO_0008134Molecular functiontranscription factor binding
GO_0048487Molecular functionbeta-tubulin binding
GO_0051787Molecular functionmisfolded protein binding
GO_0051879Molecular functionHsp90 protein binding
GO_0001222Molecular functiontranscription corepressor binding
GO_0031625Molecular functionubiquitin protein ligase binding
GO_0008270Molecular functionzinc ion binding
GO_0048156Molecular functiontau protein binding
GO_0031593Molecular functionpolyubiquitin modification-dependent protein binding
GO_0000978Molecular functionRNA polymerase II cis-regulatory region sequence-specific DNA binding
GO_0003779Molecular functionactin binding
GO_0043130Molecular functionubiquitin binding
GO_0042826Molecular functionhistone deacetylase binding
GO_0019899Molecular functionenzyme binding
GO_0004407Molecular functionhistone deacetylase activity
GO_0042903Molecular functiontubulin deacetylase activity
GO_0047611Molecular functionacetylspermidine deacetylase activity
GO_0005515Molecular functionprotein binding
GO_0033558Molecular functionprotein lysine deacetylase activity
GO_0008013Molecular functionbeta-catenin binding
GO_0043014Molecular functionalpha-tubulin binding
GO_0008017Molecular functionmicrotubule binding
GO_0070840Molecular functiondynein complex binding

IV. Literature review

[source]
Gene nameHDAC6
Protein nameHDAC6 protein (Histone deacetylase 6)
Histone deacetylase 6
Histone deacetylase 6 (HD6) (EC 3.5.1.98) (Protein deacetylase HDAC6) (EC 3.5.1.-) (Tubulin-lysine deacetylase HDAC6) (EC 3.5.1.-)
SynonymsKIAA0901
JM21
DescriptionFUNCTION: Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4) . Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events . Histone deacetylases act via the formation of large multiprotein complexes . In addition to histones, deacetylates other proteins, such as CTTN, tubulin and SQSTM1 . Plays a central role in microtubule-dependent cell motility by mediating deacetylation of tubulin . Required for cilia disassembly; via deacetylation of alpha-tubulin . Promotes deacetylation of CTTN, leading to actin polymerization, promotion of autophagosome-lysosome fusion and completion of autophagy . Involved in the MTA1-mediated epigenetic regulation of ESR1 expression in breast cancer . Promotes odontoblast differentiation following IPO7-mediated nuclear import and subsequent repression of RUNX2 expression (By similarity). In addition to its protein deacetylase activity, plays a key role in the degradation of misfolded proteins: when misfolded proteins are too abundant to be degraded by the chaperone refolding system and the ubiquitin-proteasome, mediates the transport of misfolded proteins to a cytoplasmic juxtanuclear structure called aggresome . Probably acts as an adapter that recognizes polyubiquitinated misfolded proteins and target them to the aggresome, facilitating their clearance by autophagy . .

AccessionsENST00000462730.5
ENST00000498808.7
ENST00000646703.2
ENST00000440653.2 [Q9UBN7-1]
ENST00000697886.1
ENST00000477561.6
ENST00000423941.6 [Q9UBN7-1]
ENST00000697348.1
ENST00000642405.2
ENST00000644068.1 [Q9UBN7-1]
ENST00000441703.6
ENST00000465269.6
A0A2R8Y5Z4
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ENST00000423941.5
ENST00000643934.1
ENST00000376610.7 [Q9UBN7-1]
ENST00000643374.2 [Q9UBN7-1]
ENST00000443563.5
ENST00000647398.2
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ENST00000697328.1
ENST00000443563.6 [Q9UBN7-1]
ENST00000697368.1
ENST00000334136.11 [Q9UBN7-1]
ENST00000376643.7 [Q9UBN7-1]
ENST00000476625.5
ENST00000376610.6
ENST00000697349.1
ENST00000469223.6
ENST00000697320.1
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ENST00000461608.2
A0A8V8TKY7
ENST00000376643.6
ENST00000489352.5
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E7EP63
ENST00000480525.6
ENST00000438518.6
Q9BRX7
A0A2R8YDE6
C9J172
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ENST00000376619.7 [Q9UBN7-1]
A6NDI8
ENST00000440653.1
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Q9UBN7