HAGH | OmnibusX

I. Expression across cell types

Name	Number of supported studies	Average coverage
ciliated cell	15 studies	31% ± 13%	Explore
erythrocyte	10 studies	37% ± 17%	Explore
endothelial cell	9 studies	25% ± 7%	Explore
natural killer cell	8 studies	19% ± 2%	Explore
non-classical monocyte	8 studies	28% ± 13%	Explore
neuron	7 studies	37% ± 18%	Explore
glutamatergic neuron	7 studies	33% ± 20%	Explore
epithelial cell	7 studies	35% ± 9%	Explore
CD4-positive, alpha-beta T cell	6 studies	18% ± 3%	Explore
epithelial cell of proximal tubule	5 studies	34% ± 8%	Explore
amacrine cell	5 studies	34% ± 13%	Explore
hepatocyte	5 studies	38% ± 23%	Explore
type I pneumocyte	5 studies	24% ± 6%	Explore
GABAergic neuron	5 studies	32% ± 16%	Explore
CD8-positive, alpha-beta T cell	4 studies	19% ± 2%	Explore
retinal ganglion cell	4 studies	66% ± 24%	Explore
plasma cell	4 studies	30% ± 7%	Explore
enterocyte	4 studies	20% ± 5%	Explore
astrocyte	4 studies	31% ± 9%	Explore
retina horizontal cell	4 studies	36% ± 15%	Explore
retinal rod cell	4 studies	25% ± 8%	Explore
macrophage	4 studies	24% ± 6%	Explore
abnormal cell	4 studies	23% ± 6%	Explore
T follicular helper cell	4 studies	16% ± 1%	Explore
interneuron	4 studies	33% ± 20%	Explore
oligodendrocyte	4 studies	28% ± 7%	Explore
plasmacytoid dendritic cell	4 studies	26% ± 6%	Explore
CD16-positive, CD56-dim natural killer cell, human	3 studies	18% ± 2%	Explore
conventional dendritic cell	3 studies	31% ± 12%	Explore
effector memory CD8-positive, alpha-beta T cell	3 studies	20% ± 2%	Explore
mature NK T cell	3 studies	17% ± 2%	Explore
naive thymus-derived CD4-positive, alpha-beta T cell	3 studies	16% ± 1%	Explore
erythroblast	3 studies	47% ± 27%	Explore
retinal bipolar neuron	3 studies	36% ± 10%	Explore
smooth muscle cell	3 studies	21% ± 4%	Explore
pericyte	3 studies	16% ± 1%	Explore
retinal cone cell	3 studies	44% ± 15%	Explore
fibroblast	3 studies	22% ± 4%	Explore
Mueller cell	3 studies	22% ± 4%	Explore
regulatory T cell	3 studies	16% ± 0%	Explore
type II pneumocyte	3 studies	22% ± 7%	Explore
enteroendocrine cell	3 studies	30% ± 17%	Explore
CD8-positive, alpha-beta memory T cell	3 studies	16% ± 1%	Explore
basal cell	3 studies	33% ± 13%	Explore
T cell	3 studies	17% ± 1%	Explore

II. Expression across tissues

Name	Number of supported studies	Average coverage
eye	7 studies	26% ± 9%	Explore
lung	7 studies	21% ± 10%	Explore
brain	7 studies	30% ± 12%	Explore
liver	5 studies	33% ± 25%	Explore
peripheral blood	3 studies	23% ± 1%	Explore
kidney	3 studies	22% ± 8%	Explore

Tissue	GTEx Coverage	GTEx Average TPM	GTEx Number of samples	TCGA Coverage	TCGA Average TPM	TCGA Number of samples
adrenal gland	100%	5818.15	258 / 258	100%	61.97	230 / 230
pancreas	100%	1729.45	328 / 328	100%	19.78	178 / 178
uterus	100%	1523.01	170 / 170	100%	20.73	459 / 459
brain	100%	4437.93	2638 / 2642	100%	32.92	705 / 705
liver	100%	6355.78	226 / 226	100%	72.47	405 / 406
thymus	100%	2224.36	652 / 653	100%	32.78	604 / 605
kidney	100%	4539.70	89 / 89	100%	28.20	898 / 901
prostate	100%	2116.74	244 / 245	100%	28.59	500 / 502
intestine	100%	2652.80	966 / 966	99%	18.57	522 / 527
stomach	100%	2322.48	359 / 359	99%	15.86	283 / 286
lung	99%	2389.90	575 / 578	99%	19.10	1148 / 1155
breast	100%	1986.09	458 / 459	99%	26.09	1102 / 1118
bladder	100%	2027.52	21 / 21	98%	19.42	495 / 504
ovary	99%	1235.82	178 / 180	99%	14.76	427 / 430
esophagus	100%	2492.81	1440 / 1445	97%	9.91	178 / 183
skin	91%	1357.15	1642 / 1809	99%	24.11	467 / 472
eye	0%	0	0 / 0	100%	17.69	80 / 80
lymph node	0%	0	0 / 0	100%	16.00	29 / 29
muscle	100%	5663.69	803 / 803	0%	0	0 / 0
spleen	100%	2089.51	241 / 241	0%	0	0 / 0
tonsil	0%	0	0 / 0	100%	18.16	45 / 45
ureter	0%	0	0 / 0	100%	23.71	1 / 1
adipose	100%	2194.06	1203 / 1204	0%	0	0 / 0
blood vessel	100%	2744.02	1333 / 1335	0%	0	0 / 0
peripheral blood	99%	3008.82	918 / 929	0%	0	0 / 0
heart	98%	4044.40	845 / 861	0%	0	0 / 0
abdomen	0%	0	0 / 0	0%	0	0 / 0
bone marrow	0%	0	0 / 0	0%	0	0 / 0
diaphragm	0%	0	0 / 0	0%	0	0 / 0
gingiva	0%	0	0 / 0	0%	0	0 / 0
nasal cavity	0%	0	0 / 0	0%	0	0 / 0
nasopharynx	0%	0	0 / 0	0%	0	0 / 0
nose	0%	0	0 / 0	0%	0	0 / 0
placenta	0%	0	0 / 0	0%	0	0 / 0
spinal column	0%	0	0 / 0	0%	0	0 / 0

III. Associated gene sets

GO_0006750	Biological process	glutathione biosynthetic process
GO_0006749	Biological process	glutathione metabolic process
GO_0019243	Biological process	methylglyoxal catabolic process to D-lactate via S-lactoyl-glutathione
GO_0005829	Cellular component	cytosol
GO_0005759	Cellular component	mitochondrial matrix
GO_0005739	Cellular component	mitochondrion
GO_0004416	Molecular function	hydroxyacylglutathione hydrolase activity
GO_0005515	Molecular function	protein binding
GO_0046872	Molecular function	metal ion binding

IV. Literature review

[source]

Gene name	HAGH
Protein name	Hydroxyacylglutathione hydrolase Hydroxyacylglutathione hydrolase, mitochondrial (EC 3.1.2.6) (Glyoxalase II) (Glx II) Hydroxyacylglutathione hydrolase, mitochondrial (EC 3.1.2.6) (Glyoxalase II)
Synonyms	HAGH1 GLO2
Description	FUNCTION: Thiolesterase that catalyzes the hydrolysis of S-D-lactoyl-glutathione to form glutathione and D-lactic acid. . FUNCTION: Thiolesterase that catalyzes the hydrolysis of S-D-lactoyl-glutathione to form glutathione and D-lactic acid. . FUNCTION: Thiolesterase that catalyzes the hydrolysis of S-D-lactoyl-glutathione to form glutathione and D-lactic acid. .
Accessions	ENST00000397353.6 [Q16775-2] H3BPQ4 ENST00000569339.1 Q16775 H3BV79 ENST00000564445.5 ENST00000455446.6 [Q16775-3] H3BPK3 ENST00000566644.5 H3BQW8 ENST00000566709.5 ENST00000397356.8 [Q16775-1]

HAGH report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

IV. Literature review