H2AC6 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0008285Biological processnegative regulation of cell population proliferation
GO_0031507Biological processheterochromatin formation
GO_0070062Cellular componentextracellular exosome
GO_0005654Cellular componentnucleoplasm
GO_0000786Cellular componentnucleosome
GO_0005634Cellular componentnucleus
GO_0046982Molecular functionprotein heterodimerization activity
GO_0031492Molecular functionnucleosomal DNA binding
GO_0005515Molecular functionprotein binding
GO_0030527Molecular functionstructural constituent of chromatin
GO_0003674Molecular functionmolecular_function

IV. Literature review

[source]
Gene nameH2AC6
Protein nameHistone H2A type 1-C (H2A-clustered histone 6) (Histone H2A/l)
SynonymsHIST1H2AC
H2AFL
DescriptionFUNCTION: Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling.

AccessionsENST00000602637.1
ENST00000377791.4
Q93077
ENST00000314088.6