GRB10 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0030178Biological processnegative regulation of Wnt signaling pathway
GO_0010467Biological processgene expression
GO_0030949Biological processpositive regulation of vascular endothelial growth factor receptor signaling pathway
GO_0070371Biological processERK1 and ERK2 cascade
GO_0008286Biological processinsulin receptor signaling pathway
GO_0120162Biological processpositive regulation of cold-induced thermogenesis
GO_0046627Biological processnegative regulation of insulin receptor signaling pathway
GO_1904738Biological processvascular associated smooth muscle cell migration
GO_0046325Biological processnegative regulation of glucose import
GO_0042326Biological processnegative regulation of phosphorylation
GO_0048009Biological processinsulin-like growth factor receptor signaling pathway
GO_0032991Cellular componentprotein-containing complex
GO_0005829Cellular componentcytosol
GO_0005886Cellular componentplasma membrane
GO_0005737Cellular componentcytoplasm
GO_0005158Molecular functioninsulin receptor binding
GO_0030159Molecular functionsignaling receptor complex adaptor activity
GO_0005515Molecular functionprotein binding

IV. Literature review

[source]
Gene nameGRB10
Protein nameGrowth factor receptor-bound protein 10
Growth factor receptor bound protein 10
Growth factor receptor-bound protein 10 (GRB10 adapter protein) (Insulin receptor-binding protein Grb-IR)
Uncharacterized protein GRB10
SynonymsKIAA0207
GRBIR
DescriptionFUNCTION: Adapter protein which modulates coupling of a number of cell surface receptor kinases with specific signaling pathways. Binds to, and suppress signals from, activated receptors tyrosine kinases, including the insulin (INSR) and insulin-like growth factor (IGF1R) receptors. The inhibitory effect can be achieved by 2 mechanisms: interference with the signaling pathway and increased receptor degradation. Delays and reduces AKT1 phosphorylation in response to insulin stimulation. Blocks association between INSR and IRS1 and IRS2 and prevents insulin-stimulated IRS1 and IRS2 tyrosine phosphorylation. Recruits NEDD4 to IGF1R, leading to IGF1R ubiquitination, increased internalization and degradation by both the proteasomal and lysosomal pathways. May play a role in mediating insulin-stimulated ubiquitination of INSR, leading to proteasomal degradation. Negatively regulates Wnt signaling by interacting with LRP6 intracellular portion and interfering with the binding of AXIN1 to LRP6. Positive regulator of the KDR/VEGFR-2 signaling pathway. May inhibit NEDD4-mediated degradation of KDR/VEGFR-2. .

AccessionsENST00000401949.6 [Q13322-1]
A0A2R8YCL1
ENST00000643299.1 [Q13322-3]
Q75MT1
ENST00000428711.1
H7C3B9
ENST00000406641.5 [Q13322-3]
ENST00000644879.1
ENST00000439044
ENST00000644769.1
ENST00000335866.7 [Q13322-3]
ENST00000398812.6 [Q13322-1]
Q75M93
ENST00000403097.6 [Q13322-3]
A0A2R8Y6Q4
ENST00000398810.6 [Q13322-3]
ENST00000357271.9 [Q13322-2]
ENST00000402497.6 [Q13322-3]
ENST00000645075.2 [Q13322-3]
ENST00000407526.6 [Q13322-3]
C9JTW6
ENST00000402578.5 [Q13322-3]
Q13322