GLMN report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0042327Biological processpositive regulation of phosphorylation
GO_0032434Biological processregulation of proteasomal ubiquitin-dependent protein catabolic process
GO_0008285Biological processnegative regulation of cell population proliferation
GO_0042692Biological processmuscle cell differentiation
GO_0001570Biological processvasculogenesis
GO_0032743Biological processpositive regulation of interleukin-2 production
GO_0042130Biological processnegative regulation of T cell proliferation
GO_0001843Biological processneural tube closure
GO_0001819Biological processpositive regulation of cytokine production
GO_0040029Biological processepigenetic regulation of gene expression
GO_0007166Biological processcell surface receptor signaling pathway
GO_0031464Cellular componentCul4A-RING E3 ubiquitin ligase complex
GO_0031463Cellular componentCul3-RING ubiquitin ligase complex
GO_0031462Cellular componentCul2-RING ubiquitin ligase complex
GO_0031461Cellular componentcullin-RING ubiquitin ligase complex
GO_0005737Cellular componentcytoplasm
GO_0055105Molecular functionubiquitin-protein transferase inhibitor activity
GO_0005171Molecular functionhepatocyte growth factor receptor binding
GO_0005102Molecular functionsignaling receptor binding
GO_0031625Molecular functionubiquitin protein ligase binding
GO_0005515Molecular functionprotein binding

IV. Literature review

[source]
Gene nameGLMN
Protein nameGlomulin (FK506-binding protein-associated protein) (FAP) (FKBP-associated protein)
Glomulin, FKBP associated protein
SynonymsFAP68
FAP48
VMGLOM
DescriptionFUNCTION: [Isoform 1]: Regulatory component of cullin-RING-based SCF (SKP1-Cullin-F-box protein) E3 ubiquitin-protein ligase complexes . Inhibits E3 ubiquitin ligase activity by binding to RBX1 (via RING domain) and inhibiting its interaction with the E2 ubiquitin-conjugating enzyme CDC34 . Inhibits RBX1-mediated neddylation of CUL1 . Required for normal stability and normal cellular levels of key components of SCF ubiquitin ligase complexes, including FBXW7, RBX1, CUL1, CUL2, CUL3, CUL4A, and thereby contributes to the regulation of CCNE1 and MYC levels (By similarity). Essential for normal development of the vasculature . Contributes to the regulation of RPS6KB1 phosphorylation . .

AccessionsM0QXG8
ENST00000495852.6
ENST00000370360.8 [Q92990-1]
ENST00000463560.1
M0QX84
ENST00000495106.5 [Q92990-2]
Q92990