Name | Number of supported studies | Average coverage | |
---|---|---|---|
glutamatergic neuron | 7 studies | 43% ± 27% | |
retinal rod cell | 7 studies | 35% ± 14% | |
retinal cone cell | 7 studies | 44% ± 20% | |
GABAergic neuron | 7 studies | 38% ± 22% | |
endothelial cell | 5 studies | 27% ± 11% | |
astrocyte | 5 studies | 31% ± 7% | |
oligodendrocyte | 5 studies | 21% ± 5% | |
oligodendrocyte precursor cell | 5 studies | 31% ± 12% | |
interneuron | 5 studies | 38% ± 21% | |
microglial cell | 4 studies | 19% ± 2% | |
neuron | 3 studies | 26% ± 3% | |
GABAergic interneuron | 3 studies | 19% ± 3% | |
retinal bipolar neuron | 3 studies | 25% ± 6% | |
epithelial cell | 3 studies | 21% ± 3% | |
rod bipolar cell | 3 studies | 38% ± 16% | |
transit amplifying cell | 3 studies | 27% ± 16% |
Tissue | GTEx Coverage | GTEx Average TPM | GTEx Number of samples | TCGA Coverage | TCGA Average TPM | TCGA Number of samples |
---|---|---|---|---|---|---|
esophagus | 100% | 460.15 | 1445 / 1445 | 100% | 10.60 | 183 / 183 |
uterus | 100% | 453.89 | 170 / 170 | 100% | 14.36 | 459 / 459 |
thymus | 100% | 501.91 | 653 / 653 | 100% | 9.77 | 604 / 605 |
breast | 100% | 330.41 | 459 / 459 | 100% | 11.83 | 1116 / 1118 |
lung | 100% | 329.14 | 576 / 578 | 100% | 9.55 | 1155 / 1155 |
prostate | 100% | 455.11 | 245 / 245 | 100% | 8.44 | 500 / 502 |
ovary | 100% | 474.87 | 180 / 180 | 100% | 8.46 | 428 / 430 |
brain | 100% | 528.02 | 2629 / 2642 | 100% | 10.57 | 705 / 705 |
bladder | 100% | 418.43 | 21 / 21 | 99% | 11.82 | 500 / 504 |
adrenal gland | 100% | 344.58 | 258 / 258 | 97% | 6.34 | 223 / 230 |
intestine | 100% | 402.49 | 966 / 966 | 97% | 9.07 | 509 / 527 |
stomach | 99% | 262.38 | 357 / 359 | 97% | 8.58 | 276 / 286 |
kidney | 100% | 276.25 | 89 / 89 | 94% | 5.62 | 843 / 901 |
pancreas | 95% | 148.72 | 310 / 328 | 98% | 7.45 | 175 / 178 |
skin | 100% | 468.46 | 1808 / 1809 | 92% | 8.76 | 435 / 472 |
liver | 100% | 165.55 | 226 / 226 | 89% | 4.39 | 362 / 406 |
lymph node | 0% | 0 | 0 / 0 | 100% | 12.49 | 29 / 29 |
spleen | 100% | 467.40 | 241 / 241 | 0% | 0 | 0 / 0 |
tonsil | 0% | 0 | 0 / 0 | 100% | 10.92 | 45 / 45 |
ureter | 0% | 0 | 0 / 0 | 100% | 6.50 | 1 / 1 |
adipose | 100% | 317.07 | 1203 / 1204 | 0% | 0 | 0 / 0 |
blood vessel | 100% | 289.83 | 1333 / 1335 | 0% | 0 | 0 / 0 |
muscle | 99% | 269.74 | 798 / 803 | 0% | 0 | 0 / 0 |
heart | 96% | 259.34 | 829 / 861 | 0% | 0 | 0 / 0 |
eye | 0% | 0 | 0 / 0 | 68% | 4.74 | 54 / 80 |
peripheral blood | 48% | 231.88 | 449 / 929 | 0% | 0 | 0 / 0 |
abdomen | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
bone marrow | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
diaphragm | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
gingiva | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
nasal cavity | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
nasopharynx | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
nose | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
placenta | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
spinal column | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
GO_0042327 | Biological process | positive regulation of phosphorylation |
GO_0032434 | Biological process | regulation of proteasomal ubiquitin-dependent protein catabolic process |
GO_0008285 | Biological process | negative regulation of cell population proliferation |
GO_0042692 | Biological process | muscle cell differentiation |
GO_0001570 | Biological process | vasculogenesis |
GO_0032743 | Biological process | positive regulation of interleukin-2 production |
GO_0042130 | Biological process | negative regulation of T cell proliferation |
GO_0001843 | Biological process | neural tube closure |
GO_0001819 | Biological process | positive regulation of cytokine production |
GO_0040029 | Biological process | epigenetic regulation of gene expression |
GO_0007166 | Biological process | cell surface receptor signaling pathway |
GO_0031464 | Cellular component | Cul4A-RING E3 ubiquitin ligase complex |
GO_0031463 | Cellular component | Cul3-RING ubiquitin ligase complex |
GO_0031462 | Cellular component | Cul2-RING ubiquitin ligase complex |
GO_0031461 | Cellular component | cullin-RING ubiquitin ligase complex |
GO_0005737 | Cellular component | cytoplasm |
GO_0055105 | Molecular function | ubiquitin-protein transferase inhibitor activity |
GO_0005171 | Molecular function | hepatocyte growth factor receptor binding |
GO_0005102 | Molecular function | signaling receptor binding |
GO_0031625 | Molecular function | ubiquitin protein ligase binding |
GO_0005515 | Molecular function | protein binding |
Gene name | GLMN |
Protein name | Glomulin (FK506-binding protein-associated protein) (FAP) (FKBP-associated protein) Glomulin, FKBP associated protein |
Synonyms | FAP68 FAP48 VMGLOM |
Description | FUNCTION: [Isoform 1]: Regulatory component of cullin-RING-based SCF (SKP1-Cullin-F-box protein) E3 ubiquitin-protein ligase complexes . Inhibits E3 ubiquitin ligase activity by binding to RBX1 (via RING domain) and inhibiting its interaction with the E2 ubiquitin-conjugating enzyme CDC34 . Inhibits RBX1-mediated neddylation of CUL1 . Required for normal stability and normal cellular levels of key components of SCF ubiquitin ligase complexes, including FBXW7, RBX1, CUL1, CUL2, CUL3, CUL4A, and thereby contributes to the regulation of CCNE1 and MYC levels (By similarity). Essential for normal development of the vasculature . Contributes to the regulation of RPS6KB1 phosphorylation . . |
Accessions | M0QXG8 ENST00000495852.6 ENST00000370360.8 [Q92990-1] ENST00000463560.1 M0QX84 ENST00000495106.5 [Q92990-2] Q92990 |