GIMAP5 report

I. Expression across cell types

II. Expression across tissues

sc-RNAseq data

Insufficient scRNA-seq data for expression of GIMAP5 at tissue level.

III. Associated gene sets

GO_0005765Cellular componentlysosomal membrane
GO_0032585Cellular componentmultivesicular body membrane
GO_0005525Molecular functionGTP binding
GO_0005515Molecular functionprotein binding

IV. Literature review

[source]
Gene nameGIMAP5
Protein nameGTPase IMAP family member 5 (Immune-associated nucleotide-binding protein 5) (Immunity-associated nucleotide 4-like 1 protein) (Immunity-associated nucleotide 5 protein) (IAN-5) (hIAN5) (Immunity-associated protein 3)
SynonymsIMAP3
IAN4L1
IAN5
DescriptionFUNCTION: Plays a role in T lymphocyte development and the optimal generation of CD4/CD8 double-positive thymocytes (By similarity). Inhibitor of GSK3A, possibly by sequestering GSK3A in cytoplasmic vesicles and impairing its translocation to the nucleus. Consequently, impairs GSK3A-dependent transcriptional program and regulation of the DNA damage response occurring during T cells proliferation . Required for the survival of peripheral T cells, natural killer (NK) and NK T-cell development and the maintenance of normal liver function (By similarity). May promote the survival of mature T lymphocytes upon cytokine withdrawal (By similarity). May regulate Ca(2+) homeostasis by modulating lysosomal Ca(2+) stores, preventing its accumulation in the absence of T cell activation (By similarity). May play a role in mitochondrial DNA segregation in hematopoietic tissues (By similarity). Is a regulator of liver endothelial cell homeostasis (By similarity). .

AccessionsENST00000498181.6 [Q96F15-1]
ENST00000358647.5 [Q96F15-1]
Q96F15