GDF2 report

I. Expression across cell types

Insufficient scRNA-seq data for expression of GDF2 at single-cell level.

II. Expression across tissues

sc-RNAseq data

Insufficient scRNA-seq data for expression of GDF2 at tissue level.

III. Associated gene sets

GO_0006366Biological processtranscription by RNA polymerase II
GO_0001525Biological processangiogenesis
GO_0032924Biological processactivin receptor signaling pathway
GO_0030858Biological processpositive regulation of epithelial cell differentiation
GO_0071773Biological processcellular response to BMP stimulus
GO_0045603Biological processpositive regulation of endothelial cell differentiation
GO_0045766Biological processpositive regulation of angiogenesis
GO_0001649Biological processosteoblast differentiation
GO_0001570Biological processvasculogenesis
GO_0060391Biological processpositive regulation of SMAD protein signal transduction
GO_1903348Biological processpositive regulation of bicellular tight junction assembly
GO_0043537Biological processnegative regulation of blood vessel endothelial cell migration
GO_0016525Biological processnegative regulation of angiogenesis
GO_0030509Biological processBMP signaling pathway
GO_0001569Biological processbranching involved in blood vessel morphogenesis
GO_0001937Biological processnegative regulation of endothelial cell proliferation
GO_0008156Biological processnegative regulation of DNA replication
GO_0045893Biological processpositive regulation of DNA-templated transcription
GO_0001938Biological processpositive regulation of endothelial cell proliferation
GO_0006879Biological processintracellular iron ion homeostasis
GO_0030513Biological processpositive regulation of BMP signaling pathway
GO_0032757Biological processpositive regulation of interleukin-8 production
GO_0010596Biological processnegative regulation of endothelial cell migration
GO_0048514Biological processblood vessel morphogenesis
GO_0001503Biological processossification
GO_0045747Biological processpositive regulation of Notch signaling pathway
GO_0051216Biological processcartilage development
GO_0061036Biological processpositive regulation of cartilage development
GO_0045944Biological processpositive regulation of transcription by RNA polymerase II
GO_0030308Biological processnegative regulation of cell growth
GO_0005615Cellular componentextracellular space
GO_0005576Cellular componentextracellular region
GO_0070062Cellular componentextracellular exosome
GO_0008083Molecular functiongrowth factor activity
GO_0043539Molecular functionprotein serine/threonine kinase activator activity
GO_0005515Molecular functionprotein binding
GO_0005125Molecular functioncytokine activity

IV. Literature review

[source]
Gene nameGDF2
Protein nameGrowth/differentiation factor 2 (GDF-2) (Bone morphogenetic protein 9) (BMP-9)
SynonymsBMP9
DescriptionFUNCTION: Potent circulating inhibitor of angiogenesis. Signals through the type I activin receptor ACVRL1 but not other Alks. Signaling through SMAD1 in endothelial cells requires TGF-beta coreceptor endoglin/ENG. .

AccessionsENST00000581492.3
Q9UK05