GCHFR report

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I. Expression across cell types

Cell ontologyData table

Name	Number of supported studies	Average coverage
regulatory T cell	15 studies	21% ± 5%	Explore
natural killer cell	11 studies	23% ± 7%	Explore
epithelial cell	10 studies	35% ± 14%	Explore
CD16-negative, CD56-bright natural killer cell, human	8 studies	26% ± 7%	Explore
CD4-positive, alpha-beta T cell	8 studies	18% ± 2%	Explore
CD8-positive, alpha-beta T cell	8 studies	18% ± 2%	Explore
gamma-delta T cell	8 studies	24% ± 14%	Explore
mucosal invariant T cell	8 studies	20% ± 4%	Explore
macrophage	7 studies	48% ± 18%	Explore
CD16-positive, CD56-dim natural killer cell, human	7 studies	19% ± 2%	Explore
CD8-positive, alpha-beta memory T cell	7 studies	19% ± 3%	Explore
alveolar macrophage	6 studies	69% ± 22%	Explore
epithelial cell of proximal tubule	6 studies	39% ± 13%	Explore
enterocyte	6 studies	48% ± 14%	Explore
basal cell	5 studies	32% ± 17%	Explore
club cell	5 studies	29% ± 6%	Explore
T cell	5 studies	18% ± 2%	Explore
ciliated cell	5 studies	33% ± 17%	Explore
CD4-positive, alpha-beta memory T cell	4 studies	18% ± 1%	Explore
secretory cell	4 studies	33% ± 19%	Explore
classical monocyte	4 studies	26% ± 5%	Explore
mature NK T cell	4 studies	25% ± 12%	Explore
transit amplifying cell	4 studies	27% ± 9%	Explore
T follicular helper cell	4 studies	17% ± 1%	Explore
germinal center B cell	4 studies	33% ± 11%	Explore
dendritic cell	4 studies	24% ± 4%	Explore
B cell	3 studies	49% ± 12%	Explore
squamous epithelial cell	3 studies	29% ± 11%	Explore
naive thymus-derived CD8-positive, alpha-beta T cell	3 studies	23% ± 6%	Explore
hematopoietic precursor cell	3 studies	30% ± 9%	Explore
enteroendocrine cell	3 studies	29% ± 10%	Explore
goblet cell	3 studies	22% ± 5%	Explore
progenitor cell	3 studies	33% ± 9%	Explore
serous secreting cell	3 studies	21% ± 2%	Explore
type II pneumocyte	3 studies	21% ± 4%	Explore
myeloid cell	3 studies	25% ± 3%	Explore
plasmacytoid dendritic cell	3 studies	21% ± 5%	Explore

II. Expression across tissues

sc-RNAseq dataData table

Name	Number of supported studies	Average coverage
lung	8 studies	28% ± 15%	Explore
intestine	6 studies	20% ± 6%	Explore

Bulk RNAseq dataData table

Tissue	GTEx Coverage	GTEx Average TPM	GTEx Number of samples	TCGA Coverage	TCGA Average TPM	TCGA Number of samples
liver	100%	421.03	226 / 226	54%	1.05	220 / 406
intestine	98%	66.78	943 / 966	53%	2.17	281 / 527
stomach	99%	42.81	354 / 359	51%	1.64	145 / 286
ovary	100%	66.63	180 / 180	41%	0.80	178 / 430
uterus	98%	43.47	166 / 170	34%	0.66	157 / 459
bladder	100%	49.67	21 / 21	31%	1.17	155 / 504
pancreas	94%	28.47	307 / 328	37%	0.58	66 / 178
esophagus	97%	40.65	1396 / 1445	32%	0.51	59 / 183
kidney	100%	173.73	89 / 89	25%	0.37	222 / 901
lung	100%	144.46	576 / 578	24%	0.39	280 / 1155
thymus	99%	46.68	645 / 653	22%	0.46	134 / 605
breast	100%	109.27	459 / 459	7%	0.10	80 / 1118
adrenal gland	99%	53.95	255 / 258	6%	0.08	14 / 230
prostate	100%	61.69	244 / 245	5%	0.06	23 / 502
brain	91%	41.29	2393 / 2642	10%	0.14	69 / 705
adipose	100%	116.45	1204 / 1204	0%	0	0 / 0
spleen	100%	45.36	241 / 241	0%	0	0 / 0
blood vessel	98%	52.36	1303 / 1335	0%	0	0 / 0
peripheral blood	95%	67.42	884 / 929	0%	0	0 / 0
skin	91%	60.08	1647 / 1809	3%	0.05	15 / 472
lymph node	0%	0	0 / 0	90%	2.72	26 / 29
heart	77%	20.91	666 / 861	0%	0	0 / 0
muscle	38%	6.59	303 / 803	0%	0	0 / 0
tonsil	0%	0	0 / 0	31%	0.57	14 / 45
abdomen	0%	0	0 / 0	0%	0	0 / 0
bone marrow	0%	0	0 / 0	0%	0	0 / 0
diaphragm	0%	0	0 / 0	0%	0	0 / 0
eye	0%	0	0 / 0	0%	0	0 / 80
gingiva	0%	0	0 / 0	0%	0	0 / 0
nasal cavity	0%	0	0 / 0	0%	0	0 / 0
nasopharynx	0%	0	0 / 0	0%	0	0 / 0
nose	0%	0	0 / 0	0%	0	0 / 0
placenta	0%	0	0 / 0	0%	0	0 / 0
spinal column	0%	0	0 / 0	0%	0	0 / 0
ureter	0%	0	0 / 0	0%	0	0 / 1