GBP4 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0050830Biological processdefense response to Gram-positive bacterium
GO_0042832Biological processdefense response to protozoan
GO_0071346Biological processcellular response to type II interferon
GO_0000139Cellular componentGolgi membrane
GO_0005829Cellular componentcytosol
GO_0005794Cellular componentGolgi apparatus
GO_0005886Cellular componentplasma membrane
GO_0031410Cellular componentcytoplasmic vesicle
GO_0048471Cellular componentperinuclear region of cytoplasm
GO_0005634Cellular componentnucleus
GO_0005525Molecular functionGTP binding
GO_0042803Molecular functionprotein homodimerization activity
GO_0042802Molecular functionidentical protein binding
GO_0005515Molecular functionprotein binding
GO_0003924Molecular functionGTPase activity

IV. Literature review

[source]
Gene nameGBP4
Protein nameGuanylate-binding protein 4 (EC 3.6.5.-) (GTP-binding protein 4) (GBP-4) (Guanine nucleotide-binding protein 4)
Synonyms
DescriptionFUNCTION: Interferon (IFN)-inducible GTPase that plays important roles in innate immunity against a diverse range of bacterial, viral and protozoan pathogens (By similarity). Negatively regulates the antiviral response by inhibiting activation of IRF7 transcription factor (By similarity). .

AccessionsQ96PP9
ENST00000355754.7