GARS1 | OmnibusX

I. Expression across cell types

Name	Number of supported studies	Average coverage
regulatory T cell	9 studies	21% ± 9%	Explore
endothelial cell	7 studies	20% ± 4%	Explore
epithelial cell	7 studies	29% ± 11%	Explore
plasma cell	6 studies	31% ± 11%	Explore
plasmablast	6 studies	37% ± 20%	Explore
fibroblast	6 studies	22% ± 9%	Explore
CD8-positive, alpha-beta T cell	6 studies	24% ± 10%	Explore
gamma-delta T cell	6 studies	20% ± 9%	Explore
CD4-positive, alpha-beta T cell	5 studies	30% ± 14%	Explore
goblet cell	5 studies	30% ± 12%	Explore
CD4-positive, alpha-beta memory T cell	5 studies	18% ± 2%	Explore
naive B cell	4 studies	19% ± 1%	Explore
conventional dendritic cell	4 studies	28% ± 9%	Explore
hematopoietic precursor cell	4 studies	20% ± 6%	Explore
neuron	4 studies	24% ± 9%	Explore
retinal ganglion cell	4 studies	49% ± 26%	Explore
dendritic cell	4 studies	29% ± 10%	Explore
macrophage	4 studies	18% ± 1%	Explore
glutamatergic neuron	4 studies	50% ± 19%	Explore
CD8-positive, alpha-beta memory T cell	4 studies	20% ± 3%	Explore
natural killer cell	4 studies	25% ± 12%	Explore
oligodendrocyte	4 studies	19% ± 3%	Explore
pancreatic A cell	3 studies	25% ± 8%	Explore
classical monocyte	3 studies	22% ± 3%	Explore
non-classical monocyte	3 studies	19% ± 3%	Explore
erythroblast	3 studies	29% ± 9%	Explore
CD16-negative, CD56-bright natural killer cell, human	3 studies	19% ± 3%	Explore
CD16-positive, CD56-dim natural killer cell, human	3 studies	17% ± 1%	Explore
ciliated cell	3 studies	22% ± 5%	Explore
abnormal cell	3 studies	25% ± 6%	Explore
muscle cell	3 studies	21% ± 6%	Explore
GABAergic neuron	3 studies	47% ± 8%	Explore
connective tissue cell	3 studies	26% ± 7%	Explore
megakaryocyte-erythroid progenitor cell	3 studies	33% ± 14%	Explore
erythrocyte	3 studies	31% ± 13%	Explore
basal cell	3 studies	26% ± 2%	Explore
transit amplifying cell	3 studies	22% ± 6%	Explore
plasmacytoid dendritic cell	3 studies	19% ± 4%	Explore
double negative thymocyte	3 studies	22% ± 6%	Explore
effector CD8-positive, alpha-beta T cell	3 studies	24% ± 6%	Explore
memory B cell	3 studies	25% ± 9%	Explore
mucosal invariant T cell	3 studies	18% ± 1%	Explore
astrocyte	3 studies	27% ± 2%	Explore
interneuron	3 studies	36% ± 16%	Explore
oligodendrocyte precursor cell	3 studies	22% ± 3%	Explore

II. Expression across tissues

Name	Number of supported studies	Average coverage
peripheral blood	6 studies	19% ± 4%	Explore
brain	6 studies	32% ± 13%	Explore
lung	4 studies	20% ± 4%	Explore
liver	3 studies	25% ± 9%	Explore

Tissue	GTEx Coverage	GTEx Average TPM	GTEx Number of samples	TCGA Coverage	TCGA Average TPM	TCGA Number of samples
intestine	100%	3688.67	966 / 966	100%	31.69	527 / 527
ovary	100%	3540.63	180 / 180	100%	20.43	430 / 430
pancreas	100%	3298.55	328 / 328	100%	21.39	178 / 178
skin	100%	10794.25	1809 / 1809	100%	36.22	472 / 472
stomach	100%	3956.97	359 / 359	100%	29.38	286 / 286
esophagus	100%	4898.76	1444 / 1445	100%	33.90	183 / 183
breast	100%	4362.15	459 / 459	100%	26.59	1116 / 1118
uterus	100%	3902.74	170 / 170	100%	24.54	458 / 459
bladder	100%	3969.48	21 / 21	100%	27.78	502 / 504
lung	100%	5297.33	576 / 578	100%	28.04	1154 / 1155
thymus	100%	4084.12	652 / 653	100%	19.67	603 / 605
kidney	100%	3681.83	89 / 89	99%	16.74	895 / 901
prostate	100%	3122.44	244 / 245	99%	17.07	499 / 502
brain	98%	4114.21	2591 / 2642	100%	21.22	705 / 705
adrenal gland	100%	4374.98	258 / 258	97%	24.14	223 / 230
liver	94%	2704.31	213 / 226	100%	16.77	405 / 406
adipose	100%	4779.15	1204 / 1204	0%	0	0 / 0
lymph node	0%	0	0 / 0	100%	28.73	29 / 29
spleen	100%	3352.47	241 / 241	0%	0	0 / 0
tonsil	0%	0	0 / 0	100%	23.86	45 / 45
ureter	0%	0	0 / 0	100%	10.76	1 / 1
muscle	100%	3775.43	802 / 803	0%	0	0 / 0
blood vessel	100%	4120.93	1333 / 1335	0%	0	0 / 0
eye	0%	0	0 / 0	99%	16.39	79 / 80
peripheral blood	95%	4906.52	885 / 929	0%	0	0 / 0
heart	95%	2793.55	814 / 861	0%	0	0 / 0
abdomen	0%	0	0 / 0	0%	0	0 / 0
bone marrow	0%	0	0 / 0	0%	0	0 / 0
diaphragm	0%	0	0 / 0	0%	0	0 / 0
gingiva	0%	0	0 / 0	0%	0	0 / 0
nasal cavity	0%	0	0 / 0	0%	0	0 / 0
nasopharynx	0%	0	0 / 0	0%	0	0 / 0
nose	0%	0	0 / 0	0%	0	0 / 0
placenta	0%	0	0 / 0	0%	0	0 / 0
spinal column	0%	0	0 / 0	0%	0	0 / 0

III. Associated gene sets

GO_0015966	Biological process	diadenosine tetraphosphate biosynthetic process
GO_0070150	Biological process	mitochondrial glycyl-tRNA aminoacylation
GO_0006418	Biological process	tRNA aminoacylation for protein translation
GO_0030424	Cellular component	axon
GO_0030141	Cellular component	secretory granule
GO_0070062	Cellular component	extracellular exosome
GO_0005829	Cellular component	cytosol
GO_0005759	Cellular component	mitochondrial matrix
GO_0005737	Cellular component	cytoplasm
GO_0005739	Cellular component	mitochondrion
GO_0016740	Molecular function	transferase activity
GO_0004081	Molecular function	bis(5'-nucleosyl)-tetraphosphatase (asymmetrical) activity
GO_0046983	Molecular function	protein dimerization activity
GO_0042802	Molecular function	identical protein binding
GO_0004820	Molecular function	glycine-tRNA ligase activity
GO_0005515	Molecular function	protein binding
GO_0005524	Molecular function	ATP binding

IV. Literature review

[source]

Gene name	GARS1
Protein name	Glycine--tRNA ligase (EC 6.1.1.14) (Diadenosine tetraphosphate synthetase) Uncharacterized protein GARS Glycyl-tRNA synthetase 1 glycine--tRNA ligase (EC 6.1.1.14) (Diadenosine tetraphosphate synthetase) Glycine--tRNA ligase Glycine--tRNA ligase (EC 6.1.1.14) (Diadenosine tetraphosphate synthetase) (Ap4A synthetase) (EC 2.7.7.-) (Glycyl-tRNA synthetase) (GlyRS) (Glycyl-tRNA synthetase 1)
Synonyms	GARS
Description	FUNCTION: Catalyzes the ATP-dependent ligation of glycine to the 3'-end of its cognate tRNA, via the formation of an aminoacyl-adenylate intermediate (Gly-AMP) . Also produces diadenosine tetraphosphate (Ap4A), a universal pleiotropic signaling molecule needed for cell regulation pathways, by direct condensation of 2 ATPs. Thereby, may play a special role in Ap4A homeostasis . .
Accessions	ENST00000675859.1 A0A6Q8PGA8 ENST00000444666.6 P41250 ENST00000675651.1 A0A6Q8PF45 H7C443 A0A6Q8PGZ8 ENST00000674815.1 ENST00000674807.1 A0A6Q8PGI6 ENST00000675693.1 A0A6Q8PH49 ENST00000676164.1 ENST00000389266.8 [P41250-1] A0A6Q8PGN7 A0A6Q8PFU7 ENST00000676088.1 A0A6Q8PFV5 ENST00000675051.1 ENST00000674737.1 ENST00000676210.1 A0A6Q8PHI7 A0A6Q8PGT3 A0A6Q8PHH9 ENST00000674643.1 A0A6Q8PFN0 A0A6Q8PFZ6 ENST00000675810.1 F8WCK4 ENST00000454308.6 ENST00000674851.1 ENST00000676403.1 ENST00000676259.1 ENST00000675529.1 A0A6Q8PGZ9 ENST00000674616.1 A0A6Q8PGW4 Q75MN1 ENST00000676140.1

GARS1 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

IV. Literature review