FOXO4 report

I. Expression across cell types

II. Expression across tissues

sc-RNAseq data

Insufficient scRNA-seq data for expression of FOXO4 at tissue level.

III. Associated gene sets

GO_0008285Biological processnegative regulation of cell population proliferation
GO_0006357Biological processregulation of transcription by RNA polymerase II
GO_0070317Biological processnegative regulation of G0 to G1 transition
GO_0051151Biological processnegative regulation of smooth muscle cell differentiation
GO_0014911Biological processpositive regulation of smooth muscle cell migration
GO_1990785Biological processresponse to water-immersion restraint stress
GO_0016525Biological processnegative regulation of angiogenesis
GO_0007095Biological processmitotic G2 DNA damage checkpoint signaling
GO_0031667Biological processresponse to nutrient levels
GO_0008286Biological processinsulin receptor signaling pathway
GO_0006355Biological processregulation of DNA-templated transcription
GO_0007517Biological processmuscle organ development
GO_0048863Biological processstem cell differentiation
GO_0006979Biological processresponse to oxidative stress
GO_0045944Biological processpositive regulation of transcription by RNA polymerase II
GO_0016607Cellular componentnuclear speck
GO_0005654Cellular componentnucleoplasm
GO_0005829Cellular componentcytosol
GO_0005737Cellular componentcytoplasm
GO_0000785Cellular componentchromatin
GO_0005634Cellular componentnucleus
GO_0003677Molecular functionDNA binding
GO_0019899Molecular functionenzyme binding
GO_0000978Molecular functionRNA polymerase II cis-regulatory region sequence-specific DNA binding
GO_1990841Molecular functionpromoter-specific chromatin binding
GO_0140297Molecular functionDNA-binding transcription factor binding
GO_0001228Molecular functionDNA-binding transcription activator activity, RNA polymerase II-specific
GO_0000981Molecular functionDNA-binding transcription factor activity, RNA polymerase II-specific
GO_0043565Molecular functionsequence-specific DNA binding
GO_0003676Molecular functionnucleic acid binding
GO_1990837Molecular functionsequence-specific double-stranded DNA binding
GO_0042802Molecular functionidentical protein binding
GO_0008013Molecular functionbeta-catenin binding
GO_0003700Molecular functionDNA-binding transcription factor activity
GO_0005515Molecular functionprotein binding

IV. Literature review

[source]
Gene nameFOXO4
Protein nameForkhead box protein O4 (Fork head domain transcription factor AFX1)
SynonymsAFX
MLLT7
AFX1
DescriptionFUNCTION: Transcription factor involved in the regulation of the insulin signaling pathway. Binds to insulin-response elements (IREs) and can activate transcription of IGFBP1. Down-regulates expression of HIF1A and suppresses hypoxia-induced transcriptional activation of HIF1A-modulated genes. Also involved in negative regulation of the cell cycle. Involved in increased proteasome activity in embryonic stem cells (ESCs) by activating expression of PSMD11 in ESCs, leading to enhanced assembly of the 26S proteasome, followed by higher proteasome activity. .

AccessionsP98177
ENST00000374259.8 [P98177-1]
ENST00000341558.3 [P98177-2]