FARS2 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0006432Biological processphenylalanyl-tRNA aminoacylation
GO_0008033Biological processtRNA processing
GO_0006418Biological processtRNA aminoacylation for protein translation
GO_0005759Cellular componentmitochondrial matrix
GO_0005737Cellular componentcytoplasm
GO_0005739Cellular componentmitochondrion
GO_0000049Molecular functiontRNA binding
GO_0005515Molecular functionprotein binding
GO_0004826Molecular functionphenylalanine-tRNA ligase activity
GO_0005524Molecular functionATP binding

IV. Literature review

[source]
Gene nameFARS2
Protein namephenylalanine--tRNA ligase (EC 6.1.1.20) (Phenylalanyl-tRNA synthetase)
Phenylalanyl-tRNA synthetase 2, mitochondrial
phenylalanine--tRNA ligase (EC 6.1.1.20)
Phenylalanine--tRNA ligase, mitochondrial (EC 6.1.1.20) (Phenylalanyl-tRNA synthetase) (PheRS)
SynonymsFARS1
HSPC320
DescriptionFUNCTION: Is responsible for the charging of tRNA(Phe) with phenylalanine in mitochondrial translation. To a lesser extent, also catalyzes direct attachment of m-Tyr (an oxidized version of Phe) to tRNA(Phe), thereby opening the way for delivery of the misacylated tRNA to the ribosome and incorporation of ROS-damaged amino acid into proteins. .

AccessionsO95363
ENST00000602691.1
R4GMX6
A0A3B3ITR6
Q5JRF7
ENST00000324331.10
ENST00000274680.9
ENST00000445533.1
ENST00000648580.1