ESYT1 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0120009Biological processintermembrane lipid transfer
GO_0061817Biological processendoplasmic reticulum-plasma membrane tethering
GO_0015914Biological processphospholipid transport
GO_0005783Cellular componentendoplasmic reticulum
GO_0005886Cellular componentplasma membrane
GO_0016020Cellular componentmembrane
GO_0005789Cellular componentendoplasmic reticulum membrane
GO_0120014Molecular functionphospholipid transfer activity
GO_0008429Molecular functionphosphatidylethanolamine binding
GO_0031210Molecular functionphosphatidylcholine binding
GO_0005509Molecular functioncalcium ion binding
GO_0005544Molecular functioncalcium-dependent phospholipid binding
GO_0042802Molecular functionidentical protein binding
GO_0005515Molecular functionprotein binding
GO_0035091Molecular functionphosphatidylinositol binding

IV. Literature review

[source]
Gene nameESYT1
Protein nameExtended synaptotagmin 1
Extended synaptotagmin-1 (E-Syt1) (Membrane-bound C2 domain-containing protein)
SynonymsKIAA0747
FAM62A
MBC2
DescriptionFUNCTION: Binds glycerophospholipids in a barrel-like domain and may play a role in cellular lipid transport (By similarity). Binds calcium (via the C2 domains) and translocates to sites of contact between the endoplasmic reticulum and the cell membrane in response to increased cytosolic calcium levels. Helps tether the endoplasmic reticulum to the cell membrane and promotes the formation of appositions between the endoplasmic reticulum and the cell membrane. .

AccessionsF8VZB1
ENST00000551790.5
Q9BSJ8
ENST00000394048.10 [Q9BSJ8-1]
ENST00000267113.4 [Q9BSJ8-2]