Name | Number of supported studies  | Average coverage | |
|---|---|---|---|
| microglial cell | 6 studies | 27% ± 10% | |
| GABAergic neuron | 6 studies | 36% ± 16% | |
| oligodendrocyte | 6 studies | 26% ± 9% | |
| interneuron | 5 studies | 34% ± 11% | |
| glutamatergic neuron | 4 studies | 49% ± 10% | |
| transit amplifying cell | 3 studies | 27% ± 6% | |
| macrophage | 3 studies | 24% ± 7% | |
| neuron | 3 studies | 39% ± 9% | |
| epithelial cell | 3 studies | 25% ± 4% | |
| intestinal crypt stem cell | 3 studies | 32% ± 9% | |
| astrocyte | 3 studies | 34% ± 8% |
Name | Number of supported studies | Average coverage | |
|---|---|---|---|
| brain | 7 studies | 35% ± 12% |
Tissue | GTEx Coverage | GTEx Average TPM | GTEx Number of samples | TCGA Coverage | TCGA Average TPM | TCGA Number of samples |
|---|---|---|---|---|---|---|
| ovary | 100% | 1797.86 | 180 / 180 | 93% | 16.55 | 399 / 430 |
| intestine | 98% | 2069.25 | 946 / 966 | 94% | 60.73 | 497 / 527 |
| pancreas | 100% | 477.15 | 327 / 328 | 76% | 10.03 | 135 / 178 |
| thymus | 100% | 1429.61 | 653 / 653 | 74% | 6.77 | 447 / 605 |
| brain | 97% | 758.55 | 2554 / 2642 | 77% | 9.29 | 541 / 705 |
| lung | 95% | 478.66 | 547 / 578 | 73% | 12.32 | 846 / 1155 |
| uterus | 87% | 393.87 | 148 / 170 | 76% | 13.27 | 350 / 459 |
| bladder | 86% | 553.29 | 18 / 21 | 77% | 23.65 | 388 / 504 |
| stomach | 44% | 120.64 | 157 / 359 | 91% | 48.98 | 259 / 286 |
| breast | 85% | 397.98 | 389 / 459 | 38% | 2.73 | 421 / 1118 |
| esophagus | 42% | 128.00 | 610 / 1445 | 76% | 19.33 | 139 / 183 |
| prostate | 97% | 563.44 | 237 / 245 | 6% | 0.36 | 31 / 502 |
| kidney | 88% | 481.49 | 78 / 89 | 14% | 1.53 | 130 / 901 |
| adrenal gland | 86% | 397.73 | 221 / 258 | 15% | 1.61 | 35 / 230 |
| spleen | 99% | 501.69 | 239 / 241 | 0% | 0 | 0 / 0 |
| adipose | 93% | 453.31 | 1115 / 1204 | 0% | 0 | 0 / 0 |
| skin | 66% | 381.87 | 1190 / 1809 | 14% | 1.09 | 64 / 472 |
| blood vessel | 76% | 318.38 | 1017 / 1335 | 0% | 0 | 0 / 0 |
| tonsil | 0% | 0 | 0 / 0 | 60% | 6.36 | 27 / 45 |
| heart | 58% | 340.00 | 502 / 861 | 0% | 0 | 0 / 0 |
| liver | 7% | 29.22 | 15 / 226 | 23% | 2.74 | 94 / 406 |
| lymph node | 0% | 0 | 0 / 0 | 28% | 1.37 | 8 / 29 |
| peripheral blood | 21% | 48.95 | 193 / 929 | 0% | 0 | 0 / 0 |
| muscle | 5% | 14.94 | 43 / 803 | 0% | 0 | 0 / 0 |
| eye | 0% | 0 | 0 / 0 | 3% | 0.18 | 2 / 80 |
| abdomen | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| bone marrow | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| diaphragm | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| gingiva | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| nasal cavity | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| nasopharynx | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| nose | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| placenta | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| spinal column | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| ureter | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 1 |
| GO_0048013 | Biological process | ephrin receptor signaling pathway |
| GO_0002639 | Biological process | positive regulation of immunoglobulin production |
| GO_0001655 | Biological process | urogenital system development |
| GO_0048593 | Biological process | camera-type eye morphogenesis |
| GO_0007162 | Biological process | negative regulation of cell adhesion |
| GO_1900016 | Biological process | negative regulation of cytokine production involved in inflammatory response |
| GO_2000010 | Biological process | positive regulation of protein localization to cell surface |
| GO_0021631 | Biological process | optic nerve morphogenesis |
| GO_0001933 | Biological process | negative regulation of protein phosphorylation |
| GO_0021934 | Biological process | hindbrain tangential cell migration |
| GO_0060021 | Biological process | roof of mouth development |
| GO_0050878 | Biological process | regulation of body fluid levels |
| GO_1900273 | Biological process | positive regulation of long-term synaptic potentiation |
| GO_0006468 | Biological process | protein phosphorylation |
| GO_0001525 | Biological process | angiogenesis |
| GO_0097104 | Biological process | postsynaptic membrane assembly |
| GO_0007612 | Biological process | learning |
| GO_0010628 | Biological process | positive regulation of gene expression |
| GO_0110077 | Biological process | vesicle-mediated intercellular transport |
| GO_0046580 | Biological process | negative regulation of Ras protein signal transduction |
| GO_0048168 | Biological process | regulation of neuronal synaptic plasticity |
| GO_0042113 | Biological process | B cell activation |
| GO_0042472 | Biological process | inner ear morphogenesis |
| GO_0071222 | Biological process | cellular response to lipopolysaccharide |
| GO_1904782 | Biological process | negative regulation of NMDA glutamate receptor activity |
| GO_0051965 | Biological process | positive regulation of synapse assembly |
| GO_0032760 | Biological process | positive regulation of tumor necrosis factor production |
| GO_0007399 | Biological process | nervous system development |
| GO_0051489 | Biological process | regulation of filopodium assembly |
| GO_0006469 | Biological process | negative regulation of protein kinase activity |
| GO_0031915 | Biological process | positive regulation of synaptic plasticity |
| GO_0070373 | Biological process | negative regulation of ERK1 and ERK2 cascade |
| GO_2000316 | Biological process | regulation of T-helper 17 type immune response |
| GO_0099557 | Biological process | trans-synaptic signaling by trans-synaptic complex, modulating synaptic transmission |
| GO_0021952 | Biological process | central nervous system projection neuron axonogenesis |
| GO_0060996 | Biological process | dendritic spine development |
| GO_0030890 | Biological process | positive regulation of B cell proliferation |
| GO_2000785 | Biological process | regulation of autophagosome assembly |
| GO_0022038 | Biological process | corpus callosum development |
| GO_0016310 | Biological process | phosphorylation |
| GO_0031290 | Biological process | retinal ganglion cell axon guidance |
| GO_1904646 | Biological process | cellular response to amyloid-beta |
| GO_0048170 | Biological process | positive regulation of long-term neuronal synaptic plasticity |
| GO_1904783 | Biological process | positive regulation of NMDA glutamate receptor activity |
| GO_0007611 | Biological process | learning or memory |
| GO_0061003 | Biological process | positive regulation of dendritic spine morphogenesis |
| GO_0050771 | Biological process | negative regulation of axonogenesis |
| GO_0007413 | Biological process | axonal fasciculation |
| GO_0030193 | Biological process | regulation of blood coagulation |
| GO_2000822 | Biological process | regulation of behavioral fear response |
| GO_0071679 | Biological process | commissural neuron axon guidance |
| GO_1903078 | Biological process | positive regulation of protein localization to plasma membrane |
| GO_0018108 | Biological process | peptidyl-tyrosine phosphorylation |
| GO_0030335 | Biological process | positive regulation of cell migration |
| GO_0106028 | Biological process | neuron projection retraction |
| GO_0046425 | Biological process | regulation of receptor signaling pathway via JAK-STAT |
| GO_0120192 | Biological process | tight junction assembly |
| GO_0007411 | Biological process | axon guidance |
| GO_0060997 | Biological process | dendritic spine morphogenesis |
| GO_0098978 | Cellular component | glutamatergic synapse |
| GO_0098794 | Cellular component | postsynapse |
| GO_0043025 | Cellular component | neuronal cell body |
| GO_0098686 | Cellular component | hippocampal mossy fiber to CA3 synapse |
| GO_0009986 | Cellular component | cell surface |
| GO_0045211 | Cellular component | postsynaptic membrane |
| GO_0005576 | Cellular component | extracellular region |
| GO_0005654 | Cellular component | nucleoplasm |
| GO_0042734 | Cellular component | presynaptic membrane |
| GO_0030425 | Cellular component | dendrite |
| GO_0005886 | Cellular component | plasma membrane |
| GO_0030424 | Cellular component | axon |
| GO_0043197 | Cellular component | dendritic spine |
| GO_0005829 | Cellular component | cytosol |
| GO_0042802 | Molecular function | identical protein binding |
| GO_0005524 | Molecular function | ATP binding |
| GO_0001540 | Molecular function | amyloid-beta binding |
| GO_0005102 | Molecular function | signaling receptor binding |
| GO_0004713 | Molecular function | protein tyrosine kinase activity |
| GO_0005515 | Molecular function | protein binding |
| GO_0044877 | Molecular function | protein-containing complex binding |
| GO_0008046 | Molecular function | axon guidance receptor activity |
| GO_0005005 | Molecular function | transmembrane-ephrin receptor activity |
| Gene name | EPHB2 |
| Protein name | EPH receptor B2 (EPHB2 protein) Ephrin type-B receptor 2 variant (EC 2.7.10.1) Ephrin type-B receptor 2 (EC 2.7.10.1) (Developmentally-regulated Eph-related tyrosine kinase) (ELK-related tyrosine kinase) (EPH tyrosine kinase 3) (EPH-like kinase 5) (EK5) (hEK5) (Renal carcinoma antigen NY-REN-47) (Tyrosine-protein kinase TYRO5) (Tyrosine-protein kinase receptor EPH-3) [Cleaved into: EphB2/CTF1; EphB2/CTF2] receptor protein-tyrosine kinase (EC 2.7.10.1) |
| Synonyms | EPTH3 HEK5 protein DRT ERK TYRO5 variant EPHT3 |
| Description | FUNCTION: Receptor tyrosine kinase which binds promiscuously transmembrane ephrin-B family ligands residing on adjacent cells, leading to contact-dependent bidirectional signaling into neighboring cells. The signaling pathway downstream of the receptor is referred to as forward signaling while the signaling pathway downstream of the ephrin ligand is referred to as reverse signaling. Functions in axon guidance during development. Involved in the guidance of commissural axons, that form a major interhemispheric connection between the 2 temporal lobes of the cerebral cortex. Also involved in guidance of contralateral inner ear efferent growth cones at the midline and of retinal ganglion cell axons to the optic disk. In addition to axon guidance, also regulates dendritic spines development and maturation and stimulates the formation of excitatory synapses. Upon activation by EFNB1, abolishes the ARHGEF15-mediated negative regulation on excitatory synapse formation. Controls other aspects of development including angiogenesis, palate development and in inner ear development through regulation of endolymph production. Forward and reverse signaling through the EFNB2/EPHB2 complex regulate movement and adhesion of cells that tubularize the urethra and septate the cloaca. May function as a tumor suppressor. May be involved in the regulation of platelet activation and blood coagulation . . |
| Accessions | ENST00000374632.7 [P29323-3] E2I6F7 ENST00000374630.8 [P29323-2] Q4LE53 ENST00000544305.5 B1AKC9 Q6NVW1 ENST00000374627.1 ENST00000400191.7 [P29323-1] P29323 |
