EPHA4 | OmnibusX

Name	Number of supported studies	Average coverage
endothelial cell	20 studies	30% ± 13%	Explore
glutamatergic neuron	12 studies	57% ± 24%	Explore
astrocyte	9 studies	29% ± 11%	Explore
endothelial cell of artery	6 studies	19% ± 3%	Explore
neuron	5 studies	25% ± 11%	Explore
GABAergic neuron	5 studies	36% ± 7%	Explore
retinal ganglion cell	4 studies	24% ± 3%	Explore
interneuron	4 studies	48% ± 23%	Explore
epithelial cell	3 studies	38% ± 13%	Explore
endocardial cell	3 studies	31% ± 10%	Explore
vein endothelial cell	3 studies	37% ± 23%	Explore
endothelial cell of vascular tree	3 studies	41% ± 13%	Explore
granule cell	3 studies	35% ± 20%	Explore

II. Expression across tissues

Name	Number of supported studies	Average coverage
brain	13 studies	37% ± 18%	Explore

Tissue	GTEx Coverage	GTEx Average TPM	GTEx Number of samples	TCGA Coverage	TCGA Average TPM	TCGA Number of samples
thymus	100%	2454.52	651 / 653	95%	48.39	575 / 605
brain	92%	2845.53	2439 / 2642	93%	21.30	658 / 705
prostate	96%	1287.67	235 / 245	80%	6.51	404 / 502
uterus	99%	2201.76	169 / 170	69%	9.25	319 / 459
esophagus	96%	1159.48	1382 / 1445	72%	9.15	131 / 183
ovary	99%	1792.32	179 / 180	64%	6.33	277 / 430
bladder	95%	996.57	20 / 21	66%	8.55	333 / 504
breast	100%	1711.92	457 / 459	61%	5.50	686 / 1118
lung	75%	631.81	432 / 578	81%	12.41	934 / 1155
skin	99%	2752.48	1799 / 1809	43%	7.58	205 / 472
intestine	93%	1725.95	896 / 966	43%	3.72	228 / 527
kidney	54%	495.58	48 / 89	69%	8.30	621 / 901
adipose	99%	1878.09	1191 / 1204	0%	0	0 / 0
blood vessel	97%	1574.61	1291 / 1335	0%	0	0 / 0
stomach	57%	890.74	206 / 359	38%	2.72	108 / 286
heart	90%	1980.27	777 / 861	0%	0	0 / 0
tonsil	0%	0	0 / 0	89%	11.09	40 / 45
pancreas	1%	5.33	4 / 328	88%	10.24	156 / 178
spleen	75%	495.61	180 / 241	0%	0	0 / 0
adrenal gland	46%	277.92	118 / 258	28%	2.53	64 / 230
muscle	56%	356.94	449 / 803	0%	0	0 / 0
lymph node	0%	0	0 / 0	14%	1.18	4 / 29
peripheral blood	5%	28.77	48 / 929	0%	0	0 / 0
liver	0%	1.71	1 / 226	5%	0.36	19 / 406
eye	0%	0	0 / 0	1%	0.05	1 / 80
abdomen	0%	0	0 / 0	0%	0	0 / 0
bone marrow	0%	0	0 / 0	0%	0	0 / 0
diaphragm	0%	0	0 / 0	0%	0	0 / 0
gingiva	0%	0	0 / 0	0%	0	0 / 0
nasal cavity	0%	0	0 / 0	0%	0	0 / 0
nasopharynx	0%	0	0 / 0	0%	0	0 / 0
nose	0%	0	0 / 0	0%	0	0 / 0
placenta	0%	0	0 / 0	0%	0	0 / 0
spinal column	0%	0	0 / 0	0%	0	0 / 0
ureter	0%	0	0 / 0	0%	0	0 / 1

III. Associated gene sets

GO_0061098	Biological process	positive regulation of protein tyrosine kinase activity
GO_0007628	Biological process	adult walking behavior
GO_1905806	Biological process	regulation of synapse pruning
GO_0034332	Biological process	adherens junction organization
GO_0048013	Biological process	ephrin receptor signaling pathway
GO_1903051	Biological process	negative regulation of proteolysis involved in protein catabolic process
GO_0106030	Biological process	neuron projection fasciculation
GO_0097485	Biological process	neuron projection guidance
GO_1902961	Biological process	positive regulation of aspartic-type endopeptidase activity involved in amyloid precursor protein catabolic process
GO_0070373	Biological process	negative regulation of ERK1 and ERK2 cascade
GO_1905244	Biological process	regulation of modification of synaptic structure
GO_0007162	Biological process	negative regulation of cell adhesion
GO_0007155	Biological process	cell adhesion
GO_0045785	Biological process	positive regulation of cell adhesion
GO_2001108	Biological process	positive regulation of Rho guanyl-nucleotide exchange factor activity
GO_0097156	Biological process	fasciculation of motor neuron axon
GO_0018108	Biological process	peptidyl-tyrosine phosphorylation
GO_1900038	Biological process	negative regulation of cellular response to hypoxia
GO_0010977	Biological process	negative regulation of neuron projection development
GO_0010719	Biological process	negative regulation of epithelial to mesenchymal transition
GO_0030335	Biological process	positive regulation of cell migration
GO_0043087	Biological process	regulation of GTPase activity
GO_0048710	Biological process	regulation of astrocyte differentiation
GO_0050775	Biological process	positive regulation of dendrite morphogenesis
GO_0050821	Biological process	protein stabilization
GO_0061001	Biological process	regulation of dendritic spine morphogenesis
GO_0090102	Biological process	cochlea development
GO_0098883	Biological process	synapse pruning
GO_1902004	Biological process	positive regulation of amyloid-beta formation
GO_0008347	Biological process	glial cell migration
GO_0008284	Biological process	positive regulation of cell population proliferation
GO_0030336	Biological process	negative regulation of cell migration
GO_0008045	Biological process	motor neuron axon guidance
GO_0072178	Biological process	nephric duct morphogenesis
GO_0048681	Biological process	negative regulation of axon regeneration
GO_1900272	Biological process	negative regulation of long-term synaptic potentiation
GO_0006468	Biological process	protein phosphorylation
GO_0046777	Biological process	protein autophosphorylation
GO_0097155	Biological process	fasciculation of sensory neuron axon
GO_0021957	Biological process	corticospinal tract morphogenesis
GO_1904646	Biological process	cellular response to amyloid-beta
GO_0017148	Biological process	negative regulation of translation
GO_0007411	Biological process	axon guidance
GO_0050770	Biological process	regulation of axonogenesis
GO_0098978	Cellular component	glutamatergic synapse
GO_0098839	Cellular component	postsynaptic density membrane
GO_0098685	Cellular component	Schaffer collateral - CA1 synapse
GO_0005886	Cellular component	plasma membrane
GO_0031594	Cellular component	neuromuscular junction
GO_0043197	Cellular component	dendritic spine
GO_0043198	Cellular component	dendritic shaft
GO_0043204	Cellular component	perikaryon
GO_0031901	Cellular component	early endosome membrane
GO_0043679	Cellular component	axon terminus
GO_0042734	Cellular component	presynaptic membrane
GO_0030425	Cellular component	dendrite
GO_0009986	Cellular component	cell surface
GO_0030175	Cellular component	filopodium
GO_0005912	Cellular component	adherens junction
GO_0044295	Cellular component	axonal growth cone
GO_0005737	Cellular component	cytoplasm
GO_0005741	Cellular component	mitochondrial outer membrane
GO_0030424	Cellular component	axon
GO_0005004	Molecular function	GPI-linked ephrin receptor activity
GO_0046875	Molecular function	ephrin receptor binding
GO_0004713	Molecular function	protein tyrosine kinase activity
GO_0097161	Molecular function	DH domain binding
GO_0001540	Molecular function	amyloid-beta binding
GO_0042731	Molecular function	PH domain binding
GO_0042802	Molecular function	identical protein binding
GO_1990782	Molecular function	protein tyrosine kinase binding
GO_0004672	Molecular function	protein kinase activity
GO_0005005	Molecular function	transmembrane-ephrin receptor activity
GO_0005524	Molecular function	ATP binding
GO_0016301	Molecular function	kinase activity
GO_0005515	Molecular function	protein binding

IV. Literature review

[source]

Gene name	EPHA4
Protein name	receptor protein-tyrosine kinase (EC 2.7.10.1) EPH receptor A4 Ephrin type-A receptor 4 (EC 2.7.10.1) (EPH-like kinase 8) (EK8) (hEK8) (Tyrosine-protein kinase TYRO1) (Tyrosine-protein kinase receptor SEK)
Synonyms	HEK8 SEK TYRO1
Description	FUNCTION: Receptor tyrosine kinase which binds membrane-bound ephrin family ligands residing on adjacent cells, leading to contact-dependent bidirectional signaling into neighboring cells. The signaling pathway downstream of the receptor is referred to as forward signaling while the signaling pathway downstream of the ephrin ligand is referred to as reverse signaling. Highly promiscuous, it has the unique property among Eph receptors to bind and to be physiologically activated by both GPI-anchored ephrin-A and transmembrane ephrin-B ligands including EFNA1 and EFNB3. Upon activation by ephrin ligands, modulates cell morphology and integrin-dependent cell adhesion through regulation of the Rac, Rap and Rho GTPases activity. Plays an important role in the development of the nervous system controlling different steps of axonal guidance including the establishment of the corticospinal projections. May also control the segregation of motor and sensory axons during neuromuscular circuit development. In addition to its role in axonal guidance plays a role in synaptic plasticity. Activated by EFNA1 phosphorylates CDK5 at 'Tyr-15' which in turn phosphorylates NGEF regulating RHOA and dendritic spine morphogenesis. In the nervous system, also plays a role in repair after injury preventing axonal regeneration and in angiogenesis playing a role in central nervous system vascular formation. Additionally, its promiscuity makes it available to participate in a variety of cell-cell signaling regulating for instance the development of the thymic epithelium. During development of the cochlear organ of Corti, regulates pillar cell separation by forming a ternary complex with ADAM10 and CADH1 which facilitates the cleavage of CADH1 by ADAM10 and disruption of adherens junctions (By similarity). Phosphorylates CAPRIN1, promoting CAPRIN1-dependent formation of a membraneless compartment (By similarity). .
Accessions	C9JIX8 H7C2W7 Q584H6 H7C1N8 ENST00000443796.5 E9PG71 Q58F15 ENST00000409854.5 ENST00000441679.1 ENST00000281821.7 [P54764-1] ENST00000424339.1 ENST00000541600.5 F5GZZ5 ENST00000409938.5 [P54764-1] Q53TA0 ENST00000434266.1 P54764 C9JFX5 C9JEM6 ENST00000419964.1

EPHA4 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

IV. Literature review