EPCAM report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0023019Biological processsignal transduction involved in regulation of gene expression
GO_0008284Biological processpositive regulation of cell population proliferation
GO_0001657Biological processureteric bud development
GO_0048863Biological processstem cell differentiation
GO_2000648Biological processpositive regulation of stem cell proliferation
GO_0098609Biological processcell-cell adhesion
GO_2000048Biological processnegative regulation of cell-cell adhesion mediated by cadherin
GO_0045944Biological processpositive regulation of transcription by RNA polymerase II
GO_0016323Cellular componentbasolateral plasma membrane
GO_0016324Cellular componentapical plasma membrane
GO_0009986Cellular componentcell surface
GO_0070062Cellular componentextracellular exosome
GO_0005886Cellular componentplasma membrane
GO_0016328Cellular componentlateral plasma membrane
GO_0005923Cellular componentbicellular tight junction
GO_0044877Molecular functionprotein-containing complex binding
GO_0098641Molecular functioncadherin binding involved in cell-cell adhesion
GO_0005515Molecular functionprotein binding

IV. Literature review

[source]
Gene nameEPCAM
Protein nameEpithelial cell adhesion molecule (Tumor-associated calcium signal transducer 1)
Epithelial cell adhesion molecule (Ep-CAM) (Adenocarcinoma-associated antigen) (Cell surface glycoprotein Trop-1) (Epithelial cell surface antigen) (Epithelial glycoprotein) (EGP) (Epithelial glycoprotein 314) (EGP314) (hEGP314) (KS 1/4 antigen) (KSA) (Major gastrointestinal tumor-associated protein GA733-2) (Tumor-associated calcium signal transducer 1) (CD antigen CD326)
SynonymsM4S1
TROP1
MIC18
GA733-2
M1S2
TACSTD1
DescriptionFUNCTION: May act as a physical homophilic interaction molecule between intestinal epithelial cells (IECs) and intraepithelial lymphocytes (IELs) at the mucosal epithelium for providing immunological barrier as a first line of defense against mucosal infection. Plays a role in embryonic stem cells proliferation and differentiation. Up-regulates the expression of FABP5, MYC and cyclins A and E. .

FUNCTION: May act as a physical homophilic interaction molecule between intestinal epithelial cells (IECs) and intraepithelial lymphocytes (IELs) at the mucosal epithelium for providing immunological barrier as a first line of defense against mucosal infection. Plays a role in embryonic stem cells proliferation and differentiation. Up-regulates the expression of FABP5, MYC and cyclins A and E. .

FUNCTION: May act as a physical homophilic interaction molecule between intestinal epithelial cells (IECs) and intraepithelial lymphocytes (IELs) at the mucosal epithelium for providing immunological barrier as a first line of defense against mucosal infection. Plays a role in embryonic stem cells proliferation and differentiation. Up-regulates the expression of FABP5, MYC and cyclins A and E. .

AccessionsENST00000263735.9
ENST00000456133.5
B5MCA4
P16422
ENST00000419334.1
C9JKY3
ENST00000405271.5