EHD1 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0060271Biological processcilium assembly
GO_0061512Biological processprotein localization to cilium
GO_0051260Biological processprotein homooligomerization
GO_0072659Biological processprotein localization to plasma membrane
GO_0006897Biological processendocytosis
GO_0010976Biological processpositive regulation of neuron projection development
GO_0010886Biological processpositive regulation of cholesterol storage
GO_0031175Biological processneuron projection development
GO_0006886Biological processintracellular protein transport
GO_0032456Biological processendocytic recycling
GO_1901741Biological processpositive regulation of myoblast fusion
GO_0034383Biological processlow-density lipoprotein particle clearance
GO_1990090Biological processcellular response to nerve growth factor stimulus
GO_2001137Biological processpositive regulation of endocytic recycling
GO_0042632Biological processcholesterol homeostasis
GO_0005886Cellular componentplasma membrane
GO_0005811Cellular componentlipid droplet
GO_0030139Cellular componentendocytic vesicle
GO_0048471Cellular componentperinuclear region of cytoplasm
GO_0016020Cellular componentmembrane
GO_0005769Cellular componentearly endosome
GO_0031901Cellular componentearly endosome membrane
GO_0070062Cellular componentextracellular exosome
GO_0055038Cellular componentrecycling endosome membrane
GO_0020018Cellular componentciliary pocket membrane
GO_0005737Cellular componentcytoplasm
GO_0010008Cellular componentendosome membrane
GO_0031095Cellular componentplatelet dense tubular network membrane
GO_0045296Molecular functioncadherin binding
GO_0042802Molecular functionidentical protein binding
GO_0031267Molecular functionsmall GTPase binding
GO_0005525Molecular functionGTP binding
GO_0005524Molecular functionATP binding
GO_0005509Molecular functioncalcium ion binding
GO_0005515Molecular functionprotein binding

IV. Literature review

[source]
Gene nameEHD1
Protein nameEH domain containing 1
EH domain containing 1 (EH-domain containing 1, isoform CRA_a)
EH-domain containing 1, isoform CRA_b (cDNA FLJ40523 fis, clone TESTI2046872, highly similar to EH-domain-containing protein 1) (cDNA, FLJ92624, highly similar to Homo sapiens EH-domain containing 1 (EHD1), mRNA)
EH domain-containing protein 1 (PAST homolog 1) (hPAST1) (Testilin)
SynonymsCDABP0131
hCG_23386
PAST
PAST1
DescriptionFUNCTION: ATP- and membrane-binding protein that controls membrane reorganization/tubulation upon ATP hydrolysis. In vitro causes vesiculation of endocytic membranes . Acts in early endocytic membrane fusion and membrane trafficking of recycling endosomes . Recruited to endosomal membranes upon nerve growth factor stimulation, indirectly regulates neurite outgrowth (By similarity). Plays a role in myoblast fusion (By similarity). Involved in the unidirectional retrograde dendritic transport of endocytosed BACE1 and in efficient sorting of BACE1 to axons implicating a function in neuronal APP processing (By similarity). Plays a role in the formation of the ciliary vesicle (CV), an early step in cilium biogenesis. Proposed to be required for the fusion of distal appendage vesicles (DAVs) to form the CV by recruiting SNARE complex component SNAP29. Is required for recruitment of transition zone proteins CEP290, RPGRIP1L, TMEM67 and B9D2, and of IFT20 following DAV reorganization before Rab8-dependent ciliary membrane extension. Required for the loss of CCP110 form the mother centriole essential for the maturation of the basal body during ciliogenesis . .

AccessionsENST00000359393.6
ENST00000455148.1
ENST00000411683.1
C9IZH1
Q9H4M9
ENST00000621096.4
C9J2Z4
C9JIJ3
ENST00000320631.8
C9JDQ8
ENST00000457202.1
ENST00000433803.1
ENST00000421510.5
A0A024R571
C9JC03
B2R5U3