EEIG1 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0045672Biological processpositive regulation of osteoclast differentiation
GO_0045121Cellular componentmembrane raft
GO_0005737Cellular componentcytoplasm
GO_0005634Cellular componentnucleus
GO_0005515Molecular functionprotein binding

IV. Literature review

[source]
Gene nameEEIG1
Protein nameEarly estrogen-induced gene 1 protein (EEIG1)
SynonymsC9orf132
FAM102A
DescriptionFUNCTION: Key component of TNFSF11/RANKL- and TNF-induced osteoclastogenesis pathways, thereby mediates bone resorption in pathological bone loss conditions (By similarity). Required for TNFSF11/RANKL-induced osteoclastogenesis via its interaction with TNFRSF11A/RANK, thereby facilitates the downsteam transcription of NFATC1 and activation of PLCG2 (By similarity). Facilitates recruitment of the transcriptional repressor PRDM1/BLIMP1 to the promoter of the anti-osteoclastogenesis gene IRF8, thereby resulting in transcription of osteoclast differentiation factors (By similarity). May play a role in estrogen action . .

AccessionsQ5T9C2
ENST00000373095.6 [Q5T9C2-1]
ENST00000373084.8 [Q5T9C2-3]