DNAJC10 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0070059Biological processintrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress
GO_0032781Biological processpositive regulation of ATP-dependent activity
GO_0034976Biological processresponse to endoplasmic reticulum stress
GO_0001933Biological processnegative regulation of protein phosphorylation
GO_0036498Biological processIRE1-mediated unfolded protein response
GO_0034975Biological processprotein folding in endoplasmic reticulum
GO_0036503Biological processERAD pathway
GO_0016020Cellular componentmembrane
GO_0005788Cellular componentendoplasmic reticulum lumen
GO_0005783Cellular componentendoplasmic reticulum
GO_0034663Cellular componentendoplasmic reticulum chaperone complex
GO_0051787Molecular functionmisfolded protein binding
GO_0015035Molecular functionprotein-disulfide reductase activity
GO_0051087Molecular functionprotein-folding chaperone binding
GO_0030544Molecular functionHsp70 protein binding
GO_0051117Molecular functionATPase binding
GO_0015036Molecular functiondisulfide oxidoreductase activity
GO_0016671Molecular functionoxidoreductase activity, acting on a sulfur group of donors, disulfide as acceptor
GO_0005515Molecular functionprotein binding
GO_0001671Molecular functionATPase activator activity

IV. Literature review

[source]
Gene nameDNAJC10
Protein nameDnaJ homolog subfamily C member 10 (EC 1.8.4.-) (Endoplasmic reticulum DNA J domain-containing protein 5) (ER-resident protein ERdj5) (ERdj5) (Macrothioredoxin) (MTHr)
DnaJ heat shock protein family (Hsp40) member C10
DnaJ homolog subfamily C member 10
DNAJC10 protein
SynonymsUNQ495/PRO1012
ERDJ5
DescriptionFUNCTION: Endoplasmic reticulum disulfide reductase involved both in the correct folding of proteins and degradation of misfolded proteins. Required for efficient folding of proteins in the endoplasmic reticulum by catalyzing the removal of non-native disulfide bonds formed during the folding of proteins, such as LDLR. Also involved in endoplasmic reticulum-associated degradation (ERAD) by reducing incorrect disulfide bonds in misfolded glycoproteins recognized by EDEM1. Interaction with HSPA5 is required its activity, not for the disulfide reductase activity, but to facilitate the release of DNAJC10 from its substrate. Promotes apoptotic signaling pathway in response to endoplasmic reticulum stress. .

AccessionsA0A7P0T8Y3
Q8IXB1
ENST00000679884.1
A0A7P0TB83
ENST00000679491.1
H7C1G0
ENST00000679526.1
ENST00000680258.1
A0A7P0TAQ9
ENST00000681146.1
A0A7P0Z431
A0A494C1G5
ENST00000444005.1
E7EP04
ENST00000680480.1 [Q8IXB1-3]
ENST00000681873.1
ENST00000537515.5 [Q8IXB1-3]
A0A7P0TB97
ENST00000680484.1
ENST00000650903.2
Q8N4C5
ENST00000418559.6
ENST00000616986.5 [Q8IXB1-2]
A0A7P0Z4F2
ENST00000681139.1
ENST00000680667.1
A0A7P0TB22
ENST00000264065.12 [Q8IXB1-1]
A0A7P0T9B7