Name | Number of supported studies | Average coverage | |
---|---|---|---|
B cell | 25 studies | 22% ± 6% | |
ciliated cell | 18 studies | 34% ± 13% | |
endothelial cell | 18 studies | 24% ± 9% | |
naive B cell | 14 studies | 21% ± 4% | |
memory B cell | 13 studies | 22% ± 4% | |
goblet cell | 7 studies | 38% ± 20% | |
microglial cell | 7 studies | 25% ± 8% | |
fibroblast | 7 studies | 22% ± 8% | |
endothelial cell of lymphatic vessel | 5 studies | 17% ± 1% | |
respiratory goblet cell | 5 studies | 24% ± 6% | |
astrocyte | 5 studies | 29% ± 11% | |
secretory cell | 4 studies | 23% ± 7% | |
classical monocyte | 4 studies | 22% ± 4% | |
plasmablast | 4 studies | 31% ± 16% | |
epithelial cell | 4 studies | 53% ± 26% | |
glutamatergic neuron | 4 studies | 53% ± 20% | |
abnormal cell | 4 studies | 25% ± 9% | |
macrophage | 4 studies | 24% ± 4% | |
pericyte | 4 studies | 20% ± 4% | |
oligodendrocyte | 4 studies | 27% ± 4% | |
smooth muscle cell | 3 studies | 17% ± 1% | |
plasma cell | 3 studies | 34% ± 12% | |
ionocyte | 3 studies | 24% ± 2% | |
neuron | 3 studies | 26% ± 8% | |
precursor B cell | 3 studies | 20% ± 1% | |
immature B cell | 3 studies | 26% ± 2% | |
retinal pigment epithelial cell | 3 studies | 22% ± 6% | |
acinar cell | 3 studies | 34% ± 16% | |
germinal center B cell | 3 studies | 29% ± 11% | |
GABAergic neuron | 3 studies | 51% ± 4% | |
oligodendrocyte precursor cell | 3 studies | 26% ± 7% | |
dendritic cell | 3 studies | 32% ± 9% | |
plasmacytoid dendritic cell | 3 studies | 23% ± 8% | |
interneuron | 3 studies | 48% ± 25% |
Tissue | GTEx Coverage | GTEx Average TPM | GTEx Number of samples | TCGA Coverage | TCGA Average TPM | TCGA Number of samples |
---|---|---|---|---|---|---|
lung | 100% | 6386.97 | 578 / 578 | 100% | 22.08 | 1155 / 1155 |
breast | 100% | 6120.03 | 459 / 459 | 100% | 28.73 | 1117 / 1118 |
esophagus | 100% | 4313.12 | 1443 / 1445 | 100% | 21.90 | 183 / 183 |
ovary | 100% | 6343.64 | 180 / 180 | 100% | 20.02 | 429 / 430 |
pancreas | 100% | 6130.43 | 328 / 328 | 99% | 22.97 | 177 / 178 |
prostate | 100% | 5556.41 | 244 / 245 | 100% | 33.30 | 501 / 502 |
thymus | 100% | 7490.64 | 653 / 653 | 99% | 17.48 | 600 / 605 |
uterus | 100% | 8119.73 | 170 / 170 | 99% | 18.10 | 454 / 459 |
brain | 99% | 3830.00 | 2614 / 2642 | 100% | 13.95 | 704 / 705 |
stomach | 100% | 4866.71 | 359 / 359 | 98% | 19.80 | 281 / 286 |
bladder | 100% | 5429.00 | 21 / 21 | 98% | 15.92 | 494 / 504 |
intestine | 100% | 5543.55 | 966 / 966 | 98% | 20.69 | 516 / 527 |
kidney | 100% | 4704.56 | 89 / 89 | 96% | 15.61 | 861 / 901 |
skin | 99% | 5284.30 | 1793 / 1809 | 95% | 20.42 | 448 / 472 |
adrenal gland | 100% | 3760.09 | 258 / 258 | 92% | 13.49 | 212 / 230 |
liver | 100% | 3277.59 | 225 / 226 | 71% | 7.64 | 289 / 406 |
adipose | 100% | 5832.68 | 1204 / 1204 | 0% | 0 | 0 / 0 |
blood vessel | 100% | 9523.38 | 1335 / 1335 | 0% | 0 | 0 / 0 |
lymph node | 0% | 0 | 0 / 0 | 100% | 17.54 | 29 / 29 |
spleen | 100% | 6037.71 | 241 / 241 | 0% | 0 | 0 / 0 |
ureter | 0% | 0 | 0 / 0 | 100% | 6.94 | 1 / 1 |
heart | 98% | 3741.41 | 844 / 861 | 0% | 0 | 0 / 0 |
tonsil | 0% | 0 | 0 / 0 | 98% | 13.83 | 44 / 45 |
muscle | 96% | 2097.64 | 772 / 803 | 0% | 0 | 0 / 0 |
eye | 0% | 0 | 0 / 0 | 84% | 11.19 | 67 / 80 |
peripheral blood | 41% | 1686.23 | 379 / 929 | 0% | 0 | 0 / 0 |
abdomen | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
bone marrow | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
diaphragm | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
gingiva | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
nasal cavity | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
nasopharynx | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
nose | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
placenta | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
spinal column | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
GO_0070059 | Biological process | intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress |
GO_0032781 | Biological process | positive regulation of ATP-dependent activity |
GO_0034976 | Biological process | response to endoplasmic reticulum stress |
GO_0001933 | Biological process | negative regulation of protein phosphorylation |
GO_0036498 | Biological process | IRE1-mediated unfolded protein response |
GO_0034975 | Biological process | protein folding in endoplasmic reticulum |
GO_0036503 | Biological process | ERAD pathway |
GO_0016020 | Cellular component | membrane |
GO_0005788 | Cellular component | endoplasmic reticulum lumen |
GO_0005783 | Cellular component | endoplasmic reticulum |
GO_0034663 | Cellular component | endoplasmic reticulum chaperone complex |
GO_0051787 | Molecular function | misfolded protein binding |
GO_0015035 | Molecular function | protein-disulfide reductase activity |
GO_0051087 | Molecular function | protein-folding chaperone binding |
GO_0030544 | Molecular function | Hsp70 protein binding |
GO_0051117 | Molecular function | ATPase binding |
GO_0015036 | Molecular function | disulfide oxidoreductase activity |
GO_0016671 | Molecular function | oxidoreductase activity, acting on a sulfur group of donors, disulfide as acceptor |
GO_0005515 | Molecular function | protein binding |
GO_0001671 | Molecular function | ATPase activator activity |
Gene name | DNAJC10 |
Protein name | DnaJ homolog subfamily C member 10 (EC 1.8.4.-) (Endoplasmic reticulum DNA J domain-containing protein 5) (ER-resident protein ERdj5) (ERdj5) (Macrothioredoxin) (MTHr) DnaJ heat shock protein family (Hsp40) member C10 DnaJ homolog subfamily C member 10 DNAJC10 protein |
Synonyms | UNQ495/PRO1012 ERDJ5 |
Description | FUNCTION: Endoplasmic reticulum disulfide reductase involved both in the correct folding of proteins and degradation of misfolded proteins. Required for efficient folding of proteins in the endoplasmic reticulum by catalyzing the removal of non-native disulfide bonds formed during the folding of proteins, such as LDLR. Also involved in endoplasmic reticulum-associated degradation (ERAD) by reducing incorrect disulfide bonds in misfolded glycoproteins recognized by EDEM1. Interaction with HSPA5 is required its activity, not for the disulfide reductase activity, but to facilitate the release of DNAJC10 from its substrate. Promotes apoptotic signaling pathway in response to endoplasmic reticulum stress. . |
Accessions | A0A7P0T8Y3 Q8IXB1 ENST00000679884.1 A0A7P0TB83 ENST00000679491.1 H7C1G0 ENST00000679526.1 ENST00000680258.1 A0A7P0TAQ9 ENST00000681146.1 A0A7P0Z431 A0A494C1G5 ENST00000444005.1 E7EP04 ENST00000680480.1 [Q8IXB1-3] ENST00000681873.1 ENST00000537515.5 [Q8IXB1-3] A0A7P0TB97 ENST00000680484.1 ENST00000650903.2 Q8N4C5 ENST00000418559.6 ENST00000616986.5 [Q8IXB1-2] A0A7P0Z4F2 ENST00000681139.1 ENST00000680667.1 A0A7P0TB22 ENST00000264065.12 [Q8IXB1-1] A0A7P0T9B7 |