Name | Number of supported studies  | Average coverage | |
|---|---|---|---|
| peripheral blood | 8 studies | 17% ± 2% |
Tissue | GTEx Coverage | GTEx Average TPM | GTEx Number of samples | TCGA Coverage | TCGA Average TPM | TCGA Number of samples |
|---|---|---|---|---|---|---|
| esophagus | 100% | 6186.15 | 1438 / 1445 | 99% | 26.00 | 181 / 183 |
| uterus | 100% | 2287.75 | 170 / 170 | 98% | 27.30 | 448 / 459 |
| lung | 99% | 3415.02 | 573 / 578 | 96% | 19.18 | 1114 / 1155 |
| prostate | 100% | 4143.17 | 244 / 245 | 95% | 8.88 | 475 / 502 |
| intestine | 99% | 4553.31 | 960 / 966 | 94% | 10.98 | 497 / 527 |
| bladder | 90% | 3738.00 | 19 / 21 | 98% | 22.77 | 492 / 504 |
| breast | 94% | 1915.59 | 433 / 459 | 92% | 8.86 | 1033 / 1118 |
| pancreas | 85% | 1332.43 | 278 / 328 | 98% | 21.25 | 174 / 178 |
| skin | 100% | 7822.40 | 1803 / 1809 | 80% | 7.74 | 377 / 472 |
| thymus | 91% | 1770.57 | 592 / 653 | 88% | 19.29 | 530 / 605 |
| stomach | 87% | 1397.88 | 311 / 359 | 91% | 8.37 | 259 / 286 |
| ovary | 97% | 1832.69 | 175 / 180 | 79% | 5.24 | 340 / 430 |
| brain | 65% | 1211.21 | 1709 / 2642 | 98% | 6.87 | 690 / 705 |
| adrenal gland | 95% | 1952.81 | 244 / 258 | 66% | 4.39 | 152 / 230 |
| kidney | 48% | 913.16 | 43 / 89 | 73% | 5.52 | 655 / 901 |
| lymph node | 0% | 0 | 0 / 0 | 100% | 30.83 | 29 / 29 |
| spleen | 100% | 9101.86 | 241 / 241 | 0% | 0 | 0 / 0 |
| tonsil | 0% | 0 | 0 / 0 | 100% | 37.17 | 45 / 45 |
| ureter | 0% | 0 | 0 / 0 | 100% | 14.06 | 1 / 1 |
| peripheral blood | 99% | 5341.76 | 919 / 929 | 0% | 0 | 0 / 0 |
| adipose | 97% | 1941.89 | 1163 / 1204 | 0% | 0 | 0 / 0 |
| blood vessel | 93% | 2421.70 | 1245 / 1335 | 0% | 0 | 0 / 0 |
| heart | 33% | 448.03 | 288 / 861 | 0% | 0 | 0 / 0 |
| eye | 0% | 0 | 0 / 0 | 23% | 1.28 | 18 / 80 |
| liver | 3% | 38.40 | 7 / 226 | 17% | 1.57 | 67 / 406 |
| muscle | 1% | 13.56 | 10 / 803 | 0% | 0 | 0 / 0 |
| abdomen | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| bone marrow | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| diaphragm | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| gingiva | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| nasal cavity | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| nasopharynx | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| nose | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| placenta | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| spinal column | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| GO_0006654 | Biological process | phosphatidic acid biosynthetic process |
| GO_0046339 | Biological process | diacylglycerol metabolic process |
| GO_0035556 | Biological process | intracellular signal transduction |
| GO_0046486 | Biological process | glycerolipid metabolic process |
| GO_0030168 | Biological process | platelet activation |
| GO_0046834 | Biological process | lipid phosphorylation |
| GO_0007205 | Biological process | protein kinase C-activating G protein-coupled receptor signaling pathway |
| GO_0005829 | Cellular component | cytosol |
| GO_0016020 | Cellular component | membrane |
| GO_0005886 | Cellular component | plasma membrane |
| GO_0047649 | Molecular function | alkylglycerol kinase activity |
| GO_0005524 | Molecular function | ATP binding |
| GO_0005509 | Molecular function | calcium ion binding |
| GO_0004143 | Molecular function | ATP-dependent diacylglycerol kinase activity |
| GO_0008289 | Molecular function | lipid binding |
| GO_0005543 | Molecular function | phospholipid binding |
| GO_0016301 | Molecular function | kinase activity |
| Gene name | DGKA |
| Protein name | Diacylglycerol kinase alpha (DAG kinase alpha) (EC 2.7.1.107) (EC 2.7.1.93) (80 kDa diacylglycerol kinase) (Diglyceride kinase alpha) (DGK-alpha) Diacylglycerol kinase (DAG kinase) (EC 2.7.1.107) Diacylglycerol kinase alpha |
| Synonyms | DAGK1 DAGK |
| Description | FUNCTION: Diacylglycerol kinase that converts diacylglycerol/DAG into phosphatidic acid/phosphatidate/PA and regulates the respective levels of these two bioactive lipids . Thereby, acts as a central switch between the signaling pathways activated by these second messengers with different cellular targets and opposite effects in numerous biological processes . Also plays an important role in the biosynthesis of complex lipids (Probable). Can also phosphorylate 1-alkyl-2-acylglycerol in vitro as efficiently as diacylglycerol provided it contains an arachidonoyl group . Also involved in the production of alkyl-lysophosphatidic acid, another bioactive lipid, through the phosphorylation of 1-alkyl-2-acetyl glycerol . . |
| Accessions | H0YJH4 ENST00000551156.5 [P23743-1] F8W1M3 ENST00000394147.5 [P23743-1] F8VWX8 ENST00000547015.5 ENST00000548549.5 [P23743-2] ENST00000557080.5 ENST00000555090.5 H0YJE7 ENST00000550888.1 ENST00000555218.5 F8W1H7 ENST00000549368.5 G3V4I3 ENST00000553084.5 [P23743-2] G3V312 ENST00000555025.5 ENST00000553783.5 ENST00000402956.7 [P23743-3] C9JM35 ENST00000432422.7 ENST00000551707.5 G3V4E1 ENST00000552903.2 ENST00000546878.5 ENST00000549629.5 ENST00000557180.5 G3V327 P23743 F8VNZ9 ENST00000331886.10 [P23743-1] ENST00000556001.5 |
