DDX23 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0000398Biological processmRNA splicing, via spliceosome
GO_0008380Biological processRNA splicing
GO_0000354Biological processcis assembly of pre-catalytic spliceosome
GO_0062176Biological processR-loop processing
GO_0000375Biological processRNA splicing, via transesterification reactions
GO_0046540Cellular componentU4/U6 x U5 tri-snRNP complex
GO_0005730Cellular componentnucleolus
GO_0070062Cellular componentextracellular exosome
GO_0005654Cellular componentnucleoplasm
GO_0005682Cellular componentU5 snRNP
GO_0071013Cellular componentcatalytic step 2 spliceosome
GO_0000785Cellular componentchromatin
GO_0005634Cellular componentnucleus
GO_0004386Molecular functionhelicase activity
GO_0003724Molecular functionRNA helicase activity
GO_0003729Molecular functionmRNA binding
GO_0005524Molecular functionATP binding
GO_0003723Molecular functionRNA binding
GO_0005515Molecular functionprotein binding
GO_0016887Molecular functionATP hydrolysis activity

IV. Literature review

[source]
Gene nameDDX23
Protein nameDEAD-box helicase 23
RNA helicase (EC 3.6.4.13)
Probable ATP-dependent RNA helicase DDX23 (EC 3.6.4.13) (100 kDa U5 snRNP-specific protein) (DEAD box protein 23) (PRP28 homolog) (U5-100kD)
Synonyms
DescriptionFUNCTION: Involved in pre-mRNA splicing and its phosphorylated form (by SRPK2) is required for spliceosomal B complex formation . Independently of its spliceosome formation function, required for the suppression of incorrect R-loops formed during transcription; R-loops are composed of a DNA:RNA hybrid and the associated non-template single-stranded DNA . .

AccessionsENST00000552369.6
ENST00000551468.1
ENST00000703182.1
ENST00000703181.1
H0YI52
F8W1J5
H0YIL9
ENST00000552802.5
ENST00000703179.1
F8VVA2
A0A8V8TQQ5
A0A8V8TRI2
A0A8V8TR86
Q9BUQ8
ENST00000308025.8 [Q9BUQ8-1]
ENST00000550834.1
A0A8V8TQ76
ENST00000552512.5
ENST00000547135.5 [Q9BUQ8-2]