DCAF5 | OmnibusX

I. Expression across cell types

Name	Number of supported studies	Average coverage
endothelial cell	19 studies	28% ± 13%	Explore
natural killer cell	11 studies	20% ± 4%	Explore
CD16-positive, CD56-dim natural killer cell, human	11 studies	20% ± 3%	Explore
CD16-negative, CD56-bright natural killer cell, human	10 studies	19% ± 2%	Explore
fibroblast	10 studies	22% ± 8%	Explore
astrocyte	10 studies	36% ± 15%	Explore
glutamatergic neuron	9 studies	43% ± 26%	Explore
oligodendrocyte precursor cell	9 studies	31% ± 15%	Explore
macrophage	8 studies	30% ± 11%	Explore
microglial cell	8 studies	29% ± 10%	Explore
adipocyte	8 studies	31% ± 7%	Explore
CD8-positive, alpha-beta T cell	7 studies	19% ± 2%	Explore
ciliated cell	7 studies	26% ± 8%	Explore
oligodendrocyte	7 studies	26% ± 8%	Explore
neuron	6 studies	35% ± 15%	Explore
epithelial cell	6 studies	34% ± 14%	Explore
basal cell	6 studies	26% ± 13%	Explore
T cell	6 studies	22% ± 7%	Explore
GABAergic neuron	6 studies	48% ± 21%	Explore
type I pneumocyte	6 studies	22% ± 6%	Explore
gamma-delta T cell	6 studies	20% ± 4%	Explore
effector memory CD8-positive, alpha-beta T cell	5 studies	18% ± 1%	Explore
interneuron	5 studies	44% ± 22%	Explore
dendritic cell	5 studies	20% ± 7%	Explore
club cell	5 studies	23% ± 7%	Explore
smooth muscle cell	5 studies	20% ± 2%	Explore
type II pneumocyte	5 studies	24% ± 6%	Explore
CD8-positive, alpha-beta memory T cell	5 studies	18% ± 2%	Explore
CD4-positive, alpha-beta T cell	4 studies	18% ± 1%	Explore
mature NK T cell	4 studies	18% ± 3%	Explore
granule cell	4 studies	22% ± 4%	Explore
cardiac muscle cell	4 studies	23% ± 4%	Explore
lymphocyte	4 studies	25% ± 7%	Explore
respiratory goblet cell	4 studies	25% ± 11%	Explore
monocyte	4 studies	26% ± 6%	Explore
endothelial cell of lymphatic vessel	4 studies	27% ± 7%	Explore
pericyte	4 studies	24% ± 7%	Explore
mast cell	4 studies	20% ± 3%	Explore
squamous epithelial cell	3 studies	30% ± 18%	Explore
myeloid cell	3 studies	21% ± 2%	Explore
hepatocyte	3 studies	35% ± 14%	Explore
abnormal cell	3 studies	26% ± 13%	Explore
alveolar macrophage	3 studies	32% ± 8%	Explore
goblet cell	3 studies	31% ± 16%	Explore
effector memory CD8-positive, alpha-beta T cell, terminally differentiated	3 studies	17% ± 0%	Explore

II. Expression across tissues

Name	Number of supported studies	Average coverage
brain	13 studies	33% ± 19%	Explore
lung	5 studies	20% ± 6%	Explore
heart	4 studies	18% ± 1%	Explore
peripheral blood	3 studies	18% ± 2%	Explore
eye	3 studies	28% ± 15%	Explore
intestine	3 studies	17% ± 1%	Explore
adipose	3 studies	22% ± 2%	Explore

Tissue	GTEx Coverage	GTEx Average TPM	GTEx Number of samples	TCGA Coverage	TCGA Average TPM	TCGA Number of samples
bladder	100%	6184.24	21 / 21	100%	22.77	504 / 504
esophagus	100%	6195.71	1445 / 1445	100%	29.85	183 / 183
prostate	100%	6706.21	245 / 245	100%	29.84	502 / 502
stomach	100%	4668.76	359 / 359	100%	19.28	286 / 286
lung	100%	6462.77	578 / 578	100%	26.63	1154 / 1155
thymus	100%	7167.24	653 / 653	100%	29.97	604 / 605
uterus	100%	6594.63	170 / 170	100%	25.43	458 / 459
breast	100%	6244.53	459 / 459	100%	33.47	1115 / 1118
intestine	100%	6289.73	966 / 966	100%	18.06	525 / 527
skin	100%	5388.02	1809 / 1809	99%	22.53	469 / 472
kidney	100%	4970.03	89 / 89	99%	25.07	895 / 901
brain	99%	3199.03	2621 / 2642	100%	31.67	705 / 705
pancreas	100%	2968.55	328 / 328	99%	26.18	176 / 178
adrenal gland	100%	4793.49	258 / 258	99%	21.80	227 / 230
ovary	100%	6076.85	180 / 180	99%	23.14	424 / 430
liver	100%	3609.35	226 / 226	97%	14.33	393 / 406
adipose	100%	6299.85	1204 / 1204	0%	0	0 / 0
blood vessel	100%	6462.30	1335 / 1335	0%	0	0 / 0
lymph node	0%	0	0 / 0	100%	20.50	29 / 29
muscle	100%	7709.03	803 / 803	0%	0	0 / 0
spleen	100%	6111.73	241 / 241	0%	0	0 / 0
tonsil	0%	0	0 / 0	100%	22.62	45 / 45
ureter	0%	0	0 / 0	100%	10.02	1 / 1
heart	99%	4282.17	850 / 861	0%	0	0 / 0
peripheral blood	98%	3483.83	910 / 929	0%	0	0 / 0
eye	0%	0	0 / 0	96%	16.39	77 / 80
abdomen	0%	0	0 / 0	0%	0	0 / 0
bone marrow	0%	0	0 / 0	0%	0	0 / 0
diaphragm	0%	0	0 / 0	0%	0	0 / 0
gingiva	0%	0	0 / 0	0%	0	0 / 0
nasal cavity	0%	0	0 / 0	0%	0	0 / 0
nasopharynx	0%	0	0 / 0	0%	0	0 / 0
nose	0%	0	0 / 0	0%	0	0 / 0
placenta	0%	0	0 / 0	0%	0	0 / 0
spinal column	0%	0	0 / 0	0%	0	0 / 0

III. Associated gene sets

GO_0016567	Biological process	protein ubiquitination
GO_0045717	Biological process	negative regulation of fatty acid biosynthetic process
GO_0005654	Cellular component	nucleoplasm
GO_0080008	Cellular component	Cul4-RING E3 ubiquitin ligase complex
GO_0005737	Cellular component	cytoplasm
GO_0005515	Molecular function	protein binding

IV. Literature review

[source]

Gene name	DCAF5
Protein name	DDB1 and CUL4 associated factor 5 DDB1 and CUL4 associated factor 5 (WD repeat domain 22, isoform CRA_d) (WDR22 protein) DDB1- and CUL4-associated factor 5 (Breakpoint cluster region protein 2) (BCRP2) (WD repeat-containing protein 22)
Synonyms	hCG_22244 WDR22 BCRG2 KIAA1824
Description	FUNCTION: Is a substrate receptor for the CUL4-DDB1 E3 ubiquitin-protein ligase complex (CRL4) . The complex CRL4-DCAF5 is involved in the ubiquitination of a set of methylated non-histone proteins, including SOX2, DNMT1 and E2F1 . .
Accessions	Q8TBB7 G3V4Z1 ENST00000556847.5 [Q96JK2-2] ENST00000557386.5 [Q96JK2-3] ENST00000556111.1 ENST00000389997.10 G3V3S1 ENST00000341516.10 [Q96JK2-1] ENST00000554681.1 ENST00000554215.5 [Q96JK2-2] Q96JK2

DCAF5 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

IV. Literature review