Name | Number of supported studies | Average coverage | |
---|---|---|---|
CD16-positive, CD56-dim natural killer cell, human | 9 studies | 21% ± 3% | |
natural killer cell | 8 studies | 21% ± 5% | |
CD16-negative, CD56-bright natural killer cell, human | 5 studies | 18% ± 2% | |
epithelial cell | 5 studies | 27% ± 8% | |
CD8-positive, alpha-beta T cell | 4 studies | 22% ± 4% | |
mature NK T cell | 4 studies | 19% ± 2% | |
effector CD8-positive, alpha-beta T cell | 3 studies | 18% ± 1% | |
exhausted T cell | 3 studies | 17% ± 1% | |
regulatory T cell | 3 studies | 16% ± 0% | |
classical monocyte | 3 studies | 18% ± 3% | |
dendritic cell | 3 studies | 27% ± 5% | |
non-classical monocyte | 3 studies | 28% ± 10% | |
goblet cell | 3 studies | 17% ± 0% | |
plasmacytoid dendritic cell | 3 studies | 22% ± 2% | |
gamma-delta T cell | 3 studies | 20% ± 2% | |
double negative thymocyte | 3 studies | 16% ± 1% |
Insufficient scRNA-seq data for expression of CYB561D2 at tissue level.
Tissue | GTEx Coverage | GTEx Average TPM | GTEx Number of samples | TCGA Coverage | TCGA Average TPM | TCGA Number of samples |
---|---|---|---|---|---|---|
thymus | 100% | 1393.64 | 653 / 653 | 100% | 35.55 | 604 / 605 |
skin | 100% | 789.12 | 1808 / 1809 | 100% | 30.99 | 471 / 472 |
liver | 100% | 1045.50 | 226 / 226 | 100% | 28.16 | 404 / 406 |
lung | 100% | 925.11 | 578 / 578 | 99% | 22.19 | 1149 / 1155 |
prostate | 100% | 1104.69 | 245 / 245 | 99% | 50.71 | 499 / 502 |
stomach | 100% | 964.18 | 358 / 359 | 100% | 26.70 | 285 / 286 |
breast | 100% | 836.87 | 459 / 459 | 99% | 38.38 | 1107 / 1118 |
kidney | 100% | 1081.43 | 89 / 89 | 99% | 19.86 | 892 / 901 |
pancreas | 100% | 678.23 | 328 / 328 | 99% | 24.46 | 176 / 178 |
bladder | 100% | 660.24 | 21 / 21 | 99% | 31.61 | 498 / 504 |
adrenal gland | 100% | 1130.27 | 258 / 258 | 99% | 21.32 | 227 / 230 |
uterus | 100% | 486.15 | 170 / 170 | 98% | 23.32 | 451 / 459 |
brain | 98% | 437.75 | 2597 / 2642 | 100% | 21.10 | 704 / 705 |
intestine | 99% | 856.84 | 961 / 966 | 99% | 33.90 | 520 / 527 |
ovary | 98% | 472.21 | 177 / 180 | 97% | 16.64 | 419 / 430 |
esophagus | 100% | 544.23 | 1439 / 1445 | 90% | 13.99 | 164 / 183 |
lymph node | 0% | 0 | 0 / 0 | 100% | 46.07 | 29 / 29 |
spleen | 100% | 1476.24 | 241 / 241 | 0% | 0 | 0 / 0 |
tonsil | 0% | 0 | 0 / 0 | 100% | 16.78 | 45 / 45 |
ureter | 0% | 0 | 0 / 0 | 100% | 19.26 | 1 / 1 |
adipose | 100% | 717.06 | 1203 / 1204 | 0% | 0 | 0 / 0 |
peripheral blood | 99% | 1061.08 | 923 / 929 | 0% | 0 | 0 / 0 |
eye | 0% | 0 | 0 / 0 | 99% | 19.45 | 79 / 80 |
blood vessel | 97% | 399.26 | 1300 / 1335 | 0% | 0 | 0 / 0 |
heart | 96% | 359.30 | 826 / 861 | 0% | 0 | 0 / 0 |
muscle | 89% | 321.23 | 714 / 803 | 0% | 0 | 0 / 0 |
abdomen | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
bone marrow | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
diaphragm | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
gingiva | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
nasal cavity | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
nasopharynx | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
nose | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
placenta | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
spinal column | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
GO_0140576 | Biological process | ascorbate homeostasis |
GO_0055085 | Biological process | transmembrane transport |
GO_0005783 | Cellular component | endoplasmic reticulum |
GO_0031982 | Cellular component | vesicle |
GO_0030659 | Cellular component | cytoplasmic vesicle membrane |
GO_0005789 | Cellular component | endoplasmic reticulum membrane |
GO_0140571 | Molecular function | transmembrane ascorbate ferrireductase activity |
GO_0140575 | Molecular function | transmembrane monodehydroascorbate reductase activity |
GO_0016491 | Molecular function | oxidoreductase activity |
GO_0020037 | Molecular function | heme binding |
GO_0005515 | Molecular function | protein binding |
GO_0046872 | Molecular function | metal ion binding |
Gene name | CYB561D2 |
Protein name | Transmembrane reductase CYB561D2 (EC 7.2.1.3) (Cytochrome b561 domain-containing protein 2) (Putative tumor suppressor protein 101F6) |
Synonyms | 101F6 LUCA12.2 |
Description | FUNCTION: Transmembrane reductase that may use ascorbate as an electron donor in the cytoplasm and transfer electrons across endoplasmic reticulum membranes to reduce monodehydro-L-ascorbate radical and iron cations Fe(3+) in the lumen of that compartment. . |
Accessions | ENST00000425346.6 O14569 ENST00000232508.9 ENST00000424512.5 ENST00000418577.1 |