CRK | OmnibusX

I. Expression across cell types

Name	Number of supported studies	Average coverage
endothelial cell	33 studies	27% ± 10%	Explore
fibroblast	13 studies	19% ± 5%	Explore
capillary endothelial cell	12 studies	19% ± 5%	Explore
pericyte	11 studies	21% ± 4%	Explore
endothelial cell of artery	10 studies	22% ± 4%	Explore
type I pneumocyte	9 studies	26% ± 7%	Explore
adipocyte	9 studies	25% ± 6%	Explore
endothelial cell of vascular tree	8 studies	24% ± 3%	Explore
smooth muscle cell	7 studies	19% ± 5%	Explore
epithelial cell	7 studies	37% ± 19%	Explore
macrophage	7 studies	25% ± 5%	Explore
microglial cell	6 studies	23% ± 9%	Explore
myeloid cell	6 studies	22% ± 4%	Explore
basal cell	6 studies	23% ± 7%	Explore
monocyte	6 studies	24% ± 4%	Explore
vein endothelial cell	6 studies	21% ± 5%	Explore
classical monocyte	5 studies	20% ± 5%	Explore
dendritic cell	5 studies	22% ± 8%	Explore
goblet cell	5 studies	25% ± 7%	Explore
endothelial cell of lymphatic vessel	4 studies	18% ± 1%	Explore
connective tissue cell	4 studies	22% ± 4%	Explore
GABAergic neuron	4 studies	37% ± 18%	Explore
glutamatergic neuron	4 studies	44% ± 20%	Explore
squamous epithelial cell	3 studies	35% ± 23%	Explore
non-classical monocyte	3 studies	22% ± 9%	Explore
glomerular endothelial cell	3 studies	21% ± 2%	Explore
myofibroblast cell	3 studies	23% ± 6%	Explore
retinal pigment epithelial cell	3 studies	26% ± 7%	Explore
ciliated cell	3 studies	29% ± 13%	Explore
lymphocyte	3 studies	19% ± 2%	Explore
secretory cell	3 studies	22% ± 5%	Explore
muscle cell	3 studies	25% ± 5%	Explore
type II pneumocyte	3 studies	22% ± 5%	Explore
abnormal cell	3 studies	26% ± 5%	Explore
oligodendrocyte precursor cell	3 studies	30% ± 3%	Explore
enteroendocrine cell	3 studies	19% ± 4%	Explore
interneuron	3 studies	33% ± 18%	Explore
neuron	3 studies	32% ± 9%	Explore
astrocyte	3 studies	25% ± 5%	Explore

II. Expression across tissues

Name	Number of supported studies	Average coverage
lung	6 studies	21% ± 2%	Explore
brain	6 studies	29% ± 10%	Explore
intestine	4 studies	22% ± 7%	Explore
liver	3 studies	28% ± 8%	Explore

Tissue	GTEx Coverage	GTEx Average TPM	GTEx Number of samples	TCGA Coverage	TCGA Average TPM	TCGA Number of samples
bladder	100%	4488.95	21 / 21	100%	56.90	504 / 504
esophagus	100%	4457.04	1445 / 1445	100%	88.09	183 / 183
intestine	100%	5070.20	966 / 966	100%	63.64	527 / 527
lung	100%	5426.66	578 / 578	100%	64.99	1155 / 1155
ovary	100%	3468.63	180 / 180	100%	55.01	430 / 430
prostate	100%	3705.84	245 / 245	100%	61.77	502 / 502
stomach	100%	3464.51	359 / 359	100%	64.44	286 / 286
thymus	100%	5331.22	653 / 653	100%	75.67	605 / 605
uterus	100%	4501.82	170 / 170	100%	62.72	459 / 459
brain	100%	3263.36	2640 / 2642	100%	88.41	705 / 705
breast	100%	5783.69	459 / 459	100%	75.38	1117 / 1118
liver	100%	3671.71	226 / 226	100%	40.93	405 / 406
kidney	100%	3603.20	89 / 89	99%	69.63	894 / 901
skin	100%	5002.12	1809 / 1809	99%	64.47	468 / 472
pancreas	99%	2040.12	326 / 328	99%	52.08	177 / 178
adrenal gland	100%	4085.67	258 / 258	95%	30.96	218 / 230
adipose	100%	6665.27	1204 / 1204	0%	0	0 / 0
blood vessel	100%	5492.58	1335 / 1335	0%	0	0 / 0
lymph node	0%	0	0 / 0	100%	30.74	29 / 29
spleen	100%	2961.70	241 / 241	0%	0	0 / 0
tonsil	0%	0	0 / 0	100%	63.09	45 / 45
ureter	0%	0	0 / 0	100%	25.09	1 / 1
muscle	100%	3383.52	801 / 803	0%	0	0 / 0
heart	99%	2645.03	853 / 861	0%	0	0 / 0
eye	0%	0	0 / 0	95%	37.46	76 / 80
peripheral blood	71%	1291.83	658 / 929	0%	0	0 / 0
abdomen	0%	0	0 / 0	0%	0	0 / 0
bone marrow	0%	0	0 / 0	0%	0	0 / 0
diaphragm	0%	0	0 / 0	0%	0	0 / 0
gingiva	0%	0	0 / 0	0%	0	0 / 0
nasal cavity	0%	0	0 / 0	0%	0	0 / 0
nasopharynx	0%	0	0 / 0	0%	0	0 / 0
nose	0%	0	0 / 0	0%	0	0 / 0
placenta	0%	0	0 / 0	0%	0	0 / 0
spinal column	0%	0	0 / 0	0%	0	0 / 0

III. Associated gene sets

GO_0032956	Biological process	regulation of actin cytoskeleton organization
GO_0042542	Biological process	response to hydrogen peroxide
GO_0030010	Biological process	establishment of cell polarity
GO_0009966	Biological process	regulation of signal transduction
GO_1990314	Biological process	cellular response to insulin-like growth factor stimulus
GO_0071560	Biological process	cellular response to transforming growth factor beta stimulus
GO_0048013	Biological process	ephrin receptor signaling pathway
GO_0060326	Biological process	cell chemotaxis
GO_0021766	Biological process	hippocampus development
GO_0061847	Biological process	response to cholecystokinin
GO_0008283	Biological process	cell population proliferation
GO_0061045	Biological process	negative regulation of wound healing
GO_1901652	Biological process	response to peptide
GO_0098698	Biological process	postsynaptic specialization assembly
GO_0006357	Biological process	regulation of transcription by RNA polymerase II
GO_0046330	Biological process	positive regulation of JNK cascade
GO_0007167	Biological process	enzyme-linked receptor protein signaling pathway
GO_0035685	Biological process	helper T cell diapedesis
GO_0098749	Biological process	cerebellar neuron development
GO_0001764	Biological process	neuron migration
GO_0035022	Biological process	positive regulation of Rac protein signal transduction
GO_0014911	Biological process	positive regulation of smooth muscle cell migration
GO_0050773	Biological process	regulation of dendrite development
GO_0071732	Biological process	cellular response to nitric oxide
GO_0045953	Biological process	negative regulation of natural killer cell mediated cytotoxicity
GO_0030036	Biological process	actin cytoskeleton organization
GO_1990859	Biological process	cellular response to endothelin
GO_0043087	Biological process	regulation of GTPase activity
GO_0035728	Biological process	response to hepatocyte growth factor
GO_0038026	Biological process	reelin-mediated signaling pathway
GO_0033628	Biological process	regulation of cell adhesion mediated by integrin
GO_1990090	Biological process	cellular response to nerve growth factor stimulus
GO_1902531	Biological process	regulation of intracellular signal transduction
GO_1900026	Biological process	positive regulation of substrate adhesion-dependent cell spreading
GO_0001878	Biological process	response to yeast
GO_0008360	Biological process	regulation of cell shape
GO_0021987	Biological process	cerebral cortex development
GO_1904395	Biological process	positive regulation of skeletal muscle acetylcholine-gated channel clustering
GO_0006629	Biological process	lipid metabolic process
GO_0016358	Biological process	dendrite development
GO_2000146	Biological process	negative regulation of cell motility
GO_0016477	Biological process	cell migration
GO_2000404	Biological process	regulation of T cell migration
GO_0072657	Biological process	protein localization to membrane
GO_0005886	Cellular component	plasma membrane
GO_0031594	Cellular component	neuromuscular junction
GO_0016020	Cellular component	membrane
GO_0032991	Cellular component	protein-containing complex
GO_0070062	Cellular component	extracellular exosome
GO_0015629	Cellular component	actin cytoskeleton
GO_0005829	Cellular component	cytosol
GO_0005737	Cellular component	cytoplasm
GO_0005634	Cellular component	nucleus
GO_0005159	Molecular function	insulin-like growth factor receptor binding
GO_0046875	Molecular function	ephrin receptor binding
GO_0019900	Molecular function	kinase binding
GO_0031625	Molecular function	ubiquitin protein ligase binding
GO_1990782	Molecular function	protein tyrosine kinase binding
GO_0042169	Molecular function	SH2 domain binding
GO_0097110	Molecular function	scaffold protein binding
GO_0035591	Molecular function	signaling adaptor activity
GO_0030159	Molecular function	signaling receptor complex adaptor activity
GO_0045309	Molecular function	protein phosphorylated amino acid binding
GO_0008092	Molecular function	cytoskeletal protein binding
GO_0005515	Molecular function	protein binding
GO_0001784	Molecular function	phosphotyrosine residue binding
GO_0030971	Molecular function	receptor tyrosine kinase binding
GO_0017124	Molecular function	SH3 domain binding

Gene name	CRK
Protein name	Adapter molecule crk (Proto-oncogene c-Crk) (p38) Adapter molecule crk V-crk sarcoma virus CT10 oncogene-like protein isoform 2 CRK proto-oncogene, adaptor protein
Synonyms
Description	FUNCTION: Involved in cell branching and adhesion mediated by BCAR1-CRK-RAPGEF1 signaling and activation of RAP1. .; FUNCTION: [Isoform Crk-II]: Regulates cell adhesion, spreading and migration . Mediates attachment-induced MAPK8 activation, membrane ruffling and cell motility in a Rac-dependent manner. Involved in phagocytosis of apoptotic cells and cell motility via its interaction with DOCK1 and DOCK4 . May regulate the EFNA5-EPHA3 signaling (By similarity). .
Accessions	L7RT18 ENST00000300574.3 [P46108-1] ENST00000398970.5 [P46108-2] P46108 I3L297 A0A0S2Z3Q4 A0A0S2Z3K9 ENST00000574295.1

CRK report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

IV. Literature review