Name | Number of supported studies | Average coverage | |
---|---|---|---|
fibroblast | 21 studies | 25% ± 12% | |
plasma cell | 18 studies | 38% ± 20% | |
pericyte | 13 studies | 26% ± 11% | |
endothelial cell | 12 studies | 27% ± 8% | |
smooth muscle cell | 12 studies | 22% ± 6% | |
oligodendrocyte precursor cell | 10 studies | 25% ± 13% | |
plasmacytoid dendritic cell | 9 studies | 28% ± 8% | |
oligodendrocyte | 9 studies | 28% ± 11% | |
adipocyte | 8 studies | 28% ± 4% | |
mast cell | 8 studies | 31% ± 9% | |
macrophage | 8 studies | 23% ± 6% | |
microglial cell | 7 studies | 26% ± 8% | |
epithelial cell | 6 studies | 44% ± 11% | |
club cell | 6 studies | 25% ± 9% | |
IgA plasma cell | 5 studies | 36% ± 14% | |
IgG plasma cell | 5 studies | 31% ± 10% | |
myeloid cell | 5 studies | 23% ± 6% | |
kidney loop of Henle epithelial cell | 4 studies | 25% ± 5% | |
myofibroblast cell | 4 studies | 26% ± 5% | |
astrocyte | 4 studies | 30% ± 10% | |
connective tissue cell | 4 studies | 23% ± 5% | |
type B pancreatic cell | 3 studies | 43% ± 18% | |
hematopoietic precursor cell | 3 studies | 20% ± 1% | |
lymphocyte | 3 studies | 24% ± 2% | |
respiratory goblet cell | 3 studies | 29% ± 7% | |
muscle cell | 3 studies | 33% ± 11% | |
type II pneumocyte | 3 studies | 20% ± 3% | |
GABAergic neuron | 3 studies | 24% ± 8% | |
glutamatergic neuron | 3 studies | 25% ± 7% | |
B cell | 3 studies | 21% ± 3% | |
endothelial cell of lymphatic vessel | 3 studies | 17% ± 1% | |
goblet cell | 3 studies | 17% ± 1% | |
hepatocyte | 3 studies | 37% ± 10% | |
abnormal cell | 3 studies | 27% ± 9% |
Tissue | GTEx Coverage | GTEx Average TPM | GTEx Number of samples | TCGA Coverage | TCGA Average TPM | TCGA Number of samples |
---|---|---|---|---|---|---|
prostate | 100% | 6275.12 | 245 / 245 | 100% | 53.60 | 500 / 502 |
breast | 100% | 7203.20 | 459 / 459 | 99% | 59.27 | 1109 / 1118 |
esophagus | 100% | 4961.89 | 1445 / 1445 | 99% | 38.93 | 181 / 183 |
lung | 100% | 6445.28 | 577 / 578 | 99% | 48.68 | 1138 / 1155 |
intestine | 100% | 6863.01 | 965 / 966 | 98% | 35.31 | 517 / 527 |
pancreas | 100% | 3110.51 | 327 / 328 | 97% | 37.99 | 173 / 178 |
adrenal gland | 100% | 8610.92 | 258 / 258 | 97% | 38.60 | 222 / 230 |
kidney | 100% | 4166.83 | 89 / 89 | 96% | 46.39 | 869 / 901 |
stomach | 99% | 4947.96 | 355 / 359 | 97% | 38.31 | 278 / 286 |
thymus | 100% | 14864.34 | 653 / 653 | 96% | 88.90 | 581 / 605 |
ovary | 100% | 8519.51 | 180 / 180 | 95% | 25.95 | 410 / 430 |
bladder | 100% | 5824.86 | 21 / 21 | 95% | 34.93 | 479 / 504 |
skin | 92% | 5818.97 | 1673 / 1809 | 99% | 66.05 | 466 / 472 |
uterus | 100% | 11786.08 | 170 / 170 | 84% | 24.51 | 386 / 459 |
liver | 86% | 1958.07 | 194 / 226 | 81% | 18.12 | 328 / 406 |
brain | 32% | 593.11 | 843 / 2642 | 90% | 17.78 | 631 / 705 |
adipose | 100% | 7029.98 | 1204 / 1204 | 0% | 0 | 0 / 0 |
blood vessel | 100% | 12327.39 | 1335 / 1335 | 0% | 0 | 0 / 0 |
spleen | 100% | 4128.65 | 241 / 241 | 0% | 0 | 0 / 0 |
ureter | 0% | 0 | 0 / 0 | 100% | 40.77 | 1 / 1 |
eye | 0% | 0 | 0 / 0 | 95% | 25.92 | 76 / 80 |
heart | 94% | 4240.08 | 809 / 861 | 0% | 0 | 0 / 0 |
tonsil | 0% | 0 | 0 / 0 | 82% | 21.93 | 37 / 45 |
lymph node | 0% | 0 | 0 / 0 | 62% | 21.38 | 18 / 29 |
muscle | 40% | 766.12 | 323 / 803 | 0% | 0 | 0 / 0 |
peripheral blood | 33% | 2077.47 | 307 / 929 | 0% | 0 | 0 / 0 |
abdomen | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
bone marrow | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
diaphragm | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
gingiva | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
nasal cavity | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
nasopharynx | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
nose | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
placenta | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
spinal column | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
GO_0002062 | Biological process | chondrocyte differentiation |
GO_0006986 | Biological process | response to unfolded protein |
GO_0034976 | Biological process | response to endoplasmic reticulum stress |
GO_0006888 | Biological process | endoplasmic reticulum to Golgi vesicle-mediated transport |
GO_0045893 | Biological process | positive regulation of DNA-templated transcription |
GO_0051216 | Biological process | cartilage development |
GO_0045944 | Biological process | positive regulation of transcription by RNA polymerase II |
GO_0006357 | Biological process | regulation of transcription by RNA polymerase II |
GO_0005654 | Cellular component | nucleoplasm |
GO_0005783 | Cellular component | endoplasmic reticulum |
GO_0000785 | Cellular component | chromatin |
GO_0005789 | Cellular component | endoplasmic reticulum membrane |
GO_0005634 | Cellular component | nucleus |
GO_0001228 | Molecular function | DNA-binding transcription activator activity, RNA polymerase II-specific |
GO_0035497 | Molecular function | cAMP response element binding |
GO_0000981 | Molecular function | DNA-binding transcription factor activity, RNA polymerase II-specific |
GO_0000976 | Molecular function | transcription cis-regulatory region binding |
Gene name | CREB3L2 |
Protein name | Cyclic AMP-responsive element-binding protein 3-like protein 2 (cAMP-responsive element-binding protein 3-like protein 2) (BBF2 human homolog on chromosome 7) [Cleaved into: Processed cyclic AMP-responsive element-binding protein 3-like protein 2] CREB3L2 protein cAMP responsive element binding protein 3 like 2 |
Synonyms | BBF2H7 |
Description | FUNCTION: Transcription factor involved in unfolded protein response (UPR). In the absence of endoplasmic reticulum (ER) stress, inserted into ER membranes, with N-terminal DNA-binding and transcription activation domains oriented toward the cytosolic face of the membrane. In response to ER stress, transported to the Golgi, where it is cleaved in a site-specific manner by resident proteases S1P/MBTPS1 and S2P/MBTPS2. The released N-terminal cytosolic domain is translocated to the nucleus to effect transcription of specific target genes. Plays a critical role in chondrogenesis by activating the transcription of SEC23A, which promotes the transport and secretion of cartilage matrix proteins, and possibly that of ER biogenesis-related genes (By similarity). In a neuroblastoma cell line, protects cells from ER stress-induced death . In vitro activates transcription of target genes via direct binding to the CRE site . . |
Accessions | C9JPH0 ENST00000452463.5 [Q70SY1-3] H7C1W8 ENST00000456390.5 [Q70SY1-2] ENST00000420629.1 Q70SY1 A2RRN1 ENST00000458726.5 ENST00000330387.11 [Q70SY1-1] Q86VD4 |