Name | Number of supported studies | Average coverage | |
|---|---|---|---|
| fibroblast | 21 studies | 25% ± 12% | |
| plasma cell | 18 studies | 38% ± 20% | |
| pericyte | 13 studies | 26% ± 11% | |
| endothelial cell | 12 studies | 27% ± 8% | |
| smooth muscle cell | 12 studies | 22% ± 6% | |
| oligodendrocyte precursor cell | 10 studies | 25% ± 13% | |
| plasmacytoid dendritic cell | 9 studies | 28% ± 8% | |
| oligodendrocyte | 9 studies | 28% ± 11% | |
| adipocyte | 8 studies | 28% ± 4% | |
| mast cell | 8 studies | 31% ± 9% | |
| macrophage | 8 studies | 23% ± 6% | |
| microglial cell | 7 studies | 26% ± 8% | |
| epithelial cell | 6 studies | 44% ± 11% | |
| club cell | 6 studies | 25% ± 9% | |
| IgA plasma cell | 5 studies | 36% ± 14% | |
| IgG plasma cell | 5 studies | 31% ± 10% | |
| myeloid cell | 5 studies | 23% ± 6% | |
| kidney loop of Henle epithelial cell | 4 studies | 25% ± 5% | |
| myofibroblast cell | 4 studies | 26% ± 5% | |
| astrocyte | 4 studies | 30% ± 10% | |
| connective tissue cell | 4 studies | 23% ± 5% | |
| type B pancreatic cell | 3 studies | 43% ± 18% | |
| hematopoietic precursor cell | 3 studies | 20% ± 1% | |
| lymphocyte | 3 studies | 24% ± 2% | |
| respiratory goblet cell | 3 studies | 29% ± 7% | |
| muscle cell | 3 studies | 33% ± 11% | |
| type II pneumocyte | 3 studies | 20% ± 3% | |
| GABAergic neuron | 3 studies | 24% ± 8% | |
| glutamatergic neuron | 3 studies | 25% ± 7% | |
| B cell | 3 studies | 21% ± 3% | |
| endothelial cell of lymphatic vessel | 3 studies | 17% ± 1% | |
| goblet cell | 3 studies | 17% ± 1% | |
| hepatocyte | 3 studies | 37% ± 10% | |
| abnormal cell | 3 studies | 27% ± 9% |
Tissue | GTEx Coverage | GTEx Average TPM | GTEx Number of samples | TCGA Coverage | TCGA Average TPM | TCGA Number of samples |
|---|---|---|---|---|---|---|
| prostate | 100% | 6275.12 | 245 / 245 | 100% | 53.60 | 500 / 502 |
| breast | 100% | 7203.20 | 459 / 459 | 99% | 59.27 | 1109 / 1118 |
| esophagus | 100% | 4961.89 | 1445 / 1445 | 99% | 38.93 | 181 / 183 |
| lung | 100% | 6445.28 | 577 / 578 | 99% | 48.68 | 1138 / 1155 |
| intestine | 100% | 6863.01 | 965 / 966 | 98% | 35.31 | 517 / 527 |
| pancreas | 100% | 3110.51 | 327 / 328 | 97% | 37.99 | 173 / 178 |
| adrenal gland | 100% | 8610.92 | 258 / 258 | 97% | 38.60 | 222 / 230 |
| kidney | 100% | 4166.83 | 89 / 89 | 96% | 46.39 | 869 / 901 |
| stomach | 99% | 4947.96 | 355 / 359 | 97% | 38.31 | 278 / 286 |
| thymus | 100% | 14864.34 | 653 / 653 | 96% | 88.90 | 581 / 605 |
| ovary | 100% | 8519.51 | 180 / 180 | 95% | 25.95 | 410 / 430 |
| bladder | 100% | 5824.86 | 21 / 21 | 95% | 34.93 | 479 / 504 |
| skin | 92% | 5818.97 | 1673 / 1809 | 99% | 66.05 | 466 / 472 |
| uterus | 100% | 11786.08 | 170 / 170 | 84% | 24.51 | 386 / 459 |
| liver | 86% | 1958.07 | 194 / 226 | 81% | 18.12 | 328 / 406 |
| brain | 32% | 593.11 | 843 / 2642 | 90% | 17.78 | 631 / 705 |
| adipose | 100% | 7029.98 | 1204 / 1204 | 0% | 0 | 0 / 0 |
| blood vessel | 100% | 12327.39 | 1335 / 1335 | 0% | 0 | 0 / 0 |
| spleen | 100% | 4128.65 | 241 / 241 | 0% | 0 | 0 / 0 |
| ureter | 0% | 0 | 0 / 0 | 100% | 40.77 | 1 / 1 |
| eye | 0% | 0 | 0 / 0 | 95% | 25.92 | 76 / 80 |
| heart | 94% | 4240.08 | 809 / 861 | 0% | 0 | 0 / 0 |
| tonsil | 0% | 0 | 0 / 0 | 82% | 21.93 | 37 / 45 |
| lymph node | 0% | 0 | 0 / 0 | 62% | 21.38 | 18 / 29 |
| muscle | 40% | 766.12 | 323 / 803 | 0% | 0 | 0 / 0 |
| peripheral blood | 33% | 2077.47 | 307 / 929 | 0% | 0 | 0 / 0 |
| abdomen | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| bone marrow | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| diaphragm | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| gingiva | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| nasal cavity | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| nasopharynx | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| nose | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| placenta | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| spinal column | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| GO_0002062 | Biological process | chondrocyte differentiation |
| GO_0006986 | Biological process | response to unfolded protein |
| GO_0034976 | Biological process | response to endoplasmic reticulum stress |
| GO_0006888 | Biological process | endoplasmic reticulum to Golgi vesicle-mediated transport |
| GO_0045893 | Biological process | positive regulation of DNA-templated transcription |
| GO_0051216 | Biological process | cartilage development |
| GO_0045944 | Biological process | positive regulation of transcription by RNA polymerase II |
| GO_0006357 | Biological process | regulation of transcription by RNA polymerase II |
| GO_0005654 | Cellular component | nucleoplasm |
| GO_0005783 | Cellular component | endoplasmic reticulum |
| GO_0000785 | Cellular component | chromatin |
| GO_0005789 | Cellular component | endoplasmic reticulum membrane |
| GO_0005634 | Cellular component | nucleus |
| GO_0001228 | Molecular function | DNA-binding transcription activator activity, RNA polymerase II-specific |
| GO_0035497 | Molecular function | cAMP response element binding |
| GO_0000981 | Molecular function | DNA-binding transcription factor activity, RNA polymerase II-specific |
| GO_0000976 | Molecular function | transcription cis-regulatory region binding |
| Gene name | CREB3L2 |
| Protein name | Cyclic AMP-responsive element-binding protein 3-like protein 2 (cAMP-responsive element-binding protein 3-like protein 2) (BBF2 human homolog on chromosome 7) [Cleaved into: Processed cyclic AMP-responsive element-binding protein 3-like protein 2] CREB3L2 protein cAMP responsive element binding protein 3 like 2 |
| Synonyms | BBF2H7 |
| Description | FUNCTION: Transcription factor involved in unfolded protein response (UPR). In the absence of endoplasmic reticulum (ER) stress, inserted into ER membranes, with N-terminal DNA-binding and transcription activation domains oriented toward the cytosolic face of the membrane. In response to ER stress, transported to the Golgi, where it is cleaved in a site-specific manner by resident proteases S1P/MBTPS1 and S2P/MBTPS2. The released N-terminal cytosolic domain is translocated to the nucleus to effect transcription of specific target genes. Plays a critical role in chondrogenesis by activating the transcription of SEC23A, which promotes the transport and secretion of cartilage matrix proteins, and possibly that of ER biogenesis-related genes (By similarity). In a neuroblastoma cell line, protects cells from ER stress-induced death . In vitro activates transcription of target genes via direct binding to the CRE site . . |
| Accessions | C9JPH0 ENST00000452463.5 [Q70SY1-3] H7C1W8 ENST00000456390.5 [Q70SY1-2] ENST00000420629.1 Q70SY1 A2RRN1 ENST00000458726.5 ENST00000330387.11 [Q70SY1-1] Q86VD4 |