CREB3L2 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0002062Biological processchondrocyte differentiation
GO_0006986Biological processresponse to unfolded protein
GO_0034976Biological processresponse to endoplasmic reticulum stress
GO_0006888Biological processendoplasmic reticulum to Golgi vesicle-mediated transport
GO_0045893Biological processpositive regulation of DNA-templated transcription
GO_0051216Biological processcartilage development
GO_0045944Biological processpositive regulation of transcription by RNA polymerase II
GO_0006357Biological processregulation of transcription by RNA polymerase II
GO_0005654Cellular componentnucleoplasm
GO_0005783Cellular componentendoplasmic reticulum
GO_0000785Cellular componentchromatin
GO_0005789Cellular componentendoplasmic reticulum membrane
GO_0005634Cellular componentnucleus
GO_0001228Molecular functionDNA-binding transcription activator activity, RNA polymerase II-specific
GO_0035497Molecular functioncAMP response element binding
GO_0000981Molecular functionDNA-binding transcription factor activity, RNA polymerase II-specific
GO_0000976Molecular functiontranscription cis-regulatory region binding

IV. Literature review

[source]
Gene nameCREB3L2
Protein nameCyclic AMP-responsive element-binding protein 3-like protein 2 (cAMP-responsive element-binding protein 3-like protein 2) (BBF2 human homolog on chromosome 7) [Cleaved into: Processed cyclic AMP-responsive element-binding protein 3-like protein 2]
CREB3L2 protein
cAMP responsive element binding protein 3 like 2
SynonymsBBF2H7
DescriptionFUNCTION: Transcription factor involved in unfolded protein response (UPR). In the absence of endoplasmic reticulum (ER) stress, inserted into ER membranes, with N-terminal DNA-binding and transcription activation domains oriented toward the cytosolic face of the membrane. In response to ER stress, transported to the Golgi, where it is cleaved in a site-specific manner by resident proteases S1P/MBTPS1 and S2P/MBTPS2. The released N-terminal cytosolic domain is translocated to the nucleus to effect transcription of specific target genes. Plays a critical role in chondrogenesis by activating the transcription of SEC23A, which promotes the transport and secretion of cartilage matrix proteins, and possibly that of ER biogenesis-related genes (By similarity). In a neuroblastoma cell line, protects cells from ER stress-induced death . In vitro activates transcription of target genes via direct binding to the CRE site . .

AccessionsC9JPH0
ENST00000452463.5 [Q70SY1-3]
H7C1W8
ENST00000456390.5 [Q70SY1-2]
ENST00000420629.1
Q70SY1
A2RRN1
ENST00000458726.5
ENST00000330387.11 [Q70SY1-1]
Q86VD4